Abstract: Objective To analyze the temporal variation trend of the epidemiological characteristics and disease burden of gastric cancer in Guangxi from 2011 to 2018, providing a scientific basis for formulating effective prevention and control measures. Methods Based on the incidence and mortality data of gastric cancer in Guangxi from 2011 to 2018, the crude incidence rate, crude mortality rate, age⁃standardized incidence /mortality rate by Chinese standard population (ASIRC /ASMRC), and age⁃standardized incidence/mortality rate by world standard population (ASIRW/ASMRW) were calculated to analyze the epidemiological characteristics of gastric cancer in Guangxi from 2011 to 2018; the disability⁃adjusted life⁃years (DALYs), years of life lost (YLLs) due to premature death, and years lived with disability (YLDs) due to disease were calculated to evaluate the disease burden of gastric cancer in Guangxi from 2011 to 2018. The average annual percent change (AAPC) of the above indexes was calculated by using the Joinpoint regression model to analyze the temporal variation trend of epidemiological characteristics and disease burden of gastric cancer. Results From 2011 to 2018, the ASIRC of gastric cancer in Guangxi decreased from 13.33/105 in 2011 to 10.14/105 in 2018, showed a significant downward trend (AAPC=-4.06%, P=0.002); the ASMRC decreased from 9.87/105 in 2011 to 7.90/105 in 2018 (AAPC=-2.58%, P=0.006); the DALYs rate decreased from 161.10/105 in 2011 to 138.50/105 in 2018, but the trend of change was not statistically significant (AAPC=-0.79%, P=0.366). The ASIRC, ASMRC and DALYs rate of gastric cancer in male were higher than those in female from 2011 to 2018. The ASIRC and ASMRC of gastric cancer in male decreased at an average annual rate of 2.56% (AAPC=-2.56%, P=0.181) and 1.79% (AAPC=-1.79%, P=0.190), respectively, but the trends of change were not statistically significant. The ASIRC of gastric cancer in female changed at an average annual rate of 4.40% (AAPC=-4.40%, P=0.002), showed a significant downward trend, and the ASMRC decreased at an average annual rate of 3.17% (AAPC=-3.17%, P=0.065), but the trend of change was not statistically significant. Conclusions The incidence rate and mortality rate of gastric cancer in Guangxi show a downward trend from 2011 to 2018, but the disease burden of gastric cancer is still at a relatively high level. It is necessary to continuously strengthen the prevention and treatment of gastric cancer, with focus on screening and early diagnosis and treatment for high⁃risk groups of gastric cancer, to reduce the disease burden of gastric cancer.

Key words: Gastric cancer, Incidence, Mortality, Disease burden, Trend of change