Abstract: Objective To study the safety of regional implant of slow-releasing 5-fluorouracil microparticles into abdominal cavity during the operation on hepatocellular carcinoma (HCC).Methods  Patients with radical resection of HCC were divided randomly into two groups. Treatment group were implanted slow-releasing 5-fluorouracil microparticles into abdominal cavity, the control group were without intraperitoneal chemotherapy.The blutbild, functions of liver and kidney, blood coagulation, peritoneal drainage, length of hospital stay and postoperative complications were observed.Results There were no significant difference on the indexes of blutbild, blood coagulation, functions of liver and kidney between the two groups (P＞0.05).The local pain, incidence of pleural effusion and volume of abdominal drainage were significantly higher in the treatment group than that of control group (P＜0.05).The incidences of other postoperative complication and length of hospital stay were not significantly different (P＞0.05).Conclusions Using the slow-releasing 5-Fluorouracil microparticles in patients with HCC can improve the effect of regional chemotherapy.The treatment is with less impact on organ-functions, less post-operative complications and?good safety.

Key words: Hepatocellular carcinoma, 5-Fluorouracil, Regional chemotherapy, Complication