Abstract: Objective To evaluate the efficacy of intraoperative implantation of slow-releasing 5-FU microparticles for preventing local recurrence of hepatocellular carcinoma (HCC) after curative resection.MethodsA total of 250 patients with HCC underwent curative resection from Jan 2007 to Jan 2010 was included in this study.The patients were randomly divided into 5-FU microparticles implantation group and control group.The 125 patients in implantation group were treated with hepatectomy plus implanting slow-releasing 5-FU microparticles on the wound surface,whereas the 125 patients in control group were treated with hepatectomy alone.All the patients were followed up regularly.ResultsThe recurrent rates of 1-,2-and 3-year after operation were 13.9%,31.9% and 58.8% respectively in implantation group,while they were 30.9%,40.9% and 70.9% respectively in control group.The differences between the two groups were statistically significant (P<0.05).ConclusionsIntraoperative implantation of slow-releasing 5-FU microparticles on the wound surface is an effective measure to prevent local recurrence of HCC after curative resection.

Key words: Hepatocellular carcinoma, Slow-releasing 5-FU microparticles, Recurrence