Abstract: Objective To investigate the expressions and significances of survivin and bcl-2 in cervical carcinoma, CIN and normal cervical epithelial tissues.Methods Immunohistochemical staining was used to examine the expressions of survivin and bcl-2 in 50 cases of cervical carcinoma, 20 cases of CIN I,20 cases of CIN II~III and 20 cases of normal cervical epithelial tissues.Results The expressions of survivin and bcl-2 in carcinoma were stronger than that in CIN and normal cervical epithelial tissues (P<0.05), while there was no significant difference among different degrees of cervical carcinoma.Conclusion The expression of survivin and bcl-2 are closely related to carcinogenesis of cervix.

Key words: survivin, bcl-2, Cervical carcinoma, Immunohistochemical staining