Abstract: Objective To evaluate the efficacy and safety of the 5-day chemotherapy by the combination of docetaxel,oxaliplatin and fluorouracil (DOF),or docetaxel,cisplatin and fluorouracil (DCF) as a first-line treatment for patients with advanced nasopharyngeal carcinoma.Methods60 patients with advanced nasopharyngeal carcinoma were randomly divided into group A and group B.Patients in group A (30 cases) were treated with DOF proposal as using docetaxel 75mg/m2 in d1,oxaliplatin 135mg/m2 in d1 and fluorouracil 500mg/m2 in d1～d5.Patients in group B (30 cases) were treated with DCF proposal as using docetaxel 75mg/m2 in d1,cisplatin 20mg/m2 in d1～d4 and fluorouracil 500mg/m2 in d1～d5.Both regimens were repeated once every 3 weeks for at least 2 cycles.ResultsThe clinical response rate,completed response rate,partial response rate,median progression time,median survival time,1-and 2-year survival rate were 86.67%,6.67%,60.00%,5.9mo,10.6mo,56.70% and 15.35% in group A respective1y,and 83.33%,3.33%,53.33%,5.9mo,11.4mo,58.30% and 12.47% in group B respectively.The main toxicities in two groups were bone marrow depression,nausea and hair loss,but all of them were mild and tolerable.ConclusionsThe combined chemotherapy of docetaxel,oxa1iplatin and fluorouracil,as well as docetaxel,cisplatin and fluorouracil are effective and tolerab1e for treating patients with advanced nasopharyngeal carcinoma.Comparing with best sustaining treatment,combined chemotherapy can prolong patient’s survival time and improve their life quality.In particular,the former regimen has less influence on life quality than the latter.

Key words: Docetaxel, Oxaliplatin, Fluorouracil, Cisplatin, Nasopharyngeal carcinoma