Abstract: Objective To evaluate the short-term therapeutic effect,toxicity and side effects of Cisplatin+5-Fluorouracil(PF)regimen,Docetaxel+Cisplatin+5-Fluorouracil(DPF)regimen,Gemcitabine+Cisplatin(GP)regimen,and Paclitaxel+CBP(TC)regimen on treating advanced and recurrent nasopharyngeal carcinoma(NPC).Methods Nineteen cases were treated with PF regimen,22 cases with DPF regimen,23 cases with GP regimen and 23 cases with TC regimen.The response rate,the occurrence of leukocytopenia,nausea and vomiting in each group were calculated and statistically analyzed.Result The response rates of PF,DPF,GP,and TC regimen were 42.11%,72.73%,78.26% and 56.5%,respectively.The higher response rates in the regimens of DPF and GP comparing to regimen PF were statistically significant(χ2=3.939,P=0.047;χ2=5.768,P=0.016).The occurrence rate of Ⅲ～Ⅳ grade leukocytopenia was no significantly different among the GP,TC and PF regimens(P>0.05).The difference between regimen DPF and PF was statistically significant(χ2=12.897,P=0.001).The differences of occurrence of nausea and vomiting among the four groups had no statistically significant(P>0.05).Conclusion DPF,GP and TC are effective chemotherapy regimens for advanced and recurrent NPC.

Key words: Nasopharyngeal carcinoma, Chemotherapy, Docetaxel, Gemcitabine, Cisplatin, 5-Fluorouracil