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Chinese Journal of Oncology Prevention and Treatment

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The interference effect of Chinese herbal compound on Oxaliplatin-induced neurotoxicity

LIN Yan,XU You-qi,DING Rong.   

  1. (Second Affiliated Hospital of Nanjing Medical University,Jiangsu 210011,China
  • Received:2009-12-25 Revised:2009-12-25 Online:2009-12-25 Published:2009-12-25

Abstract: Objective To observe the antagonism of Chinese medicine Yiqi Huoxue for Oxaliplatin-induced neurotoxicity.Methods 54 cases of cancer patients accepted Oxaliplatin chemotherapy were divided into treatment and control groups.Patients in the treatment group were treated with both Oxaliplatin chemotherapy and Chinese medicine Yiqi Huoxue,and patients in control groups were treated with oxaliplatin chemotherapy only.Results The clinical effect was similar in the two groups.However,the occurrence rate and degree of neurotoxicity were lower in treatment group than that in control group.Conclusions Chinese medicine Yiqi Huoxue can intervene and antagonize Oxaliplatin-induced neurotoxicity.

Key words: Chinese herbal compound, Oxaliplatin, Neurotoxicity