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Chinese Journal of Oncology Prevention and Treatment ›› 2015, Vol. 7 ›› Issue (3): 201-205.doi: 10.3969/j.issn.1674-5671.2015.03.13

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Dosimetric comparison of volumetric modulated arc therapy (RapidArc)with dynamic intensity-modulated radiotherapy for nasal natural killer/T-cell lymphoma

  

  • Online:2015-06-25 Published:2015-07-13

Abstract:

Objective To compare dosimetry between volumetric modulated arc therapy (RapidArc) and nine-field fixed-gantry dynamic intensity-modulated radiotherapy(dIMRT) for nasal natural killer/T-cell lymphoma. Methods RapidArc and dIMRT plans were generated for 10 patients with natural killer/T-cell lymphoma based on the Varian Eclipse 8.6 radiation treatment planning system. Planning target volume (PTV) and organs at risk(OAR) were evaluated using dose-volume histograms (DVHs). Results  Compared to RapidArc, the dIMRT approach showed higher Dmin for PTV (3.48 Gy,t=-3.810,P=0.004),lower Dmax for PTV (2.12 Gy,t=3.979,P=0.003),lower Dmean for PTV(1.65 Gy,t=4.933,P=0.001),superior homogeneity index(t=5.068,P=0.001),and similar conformity index. In addition,the dIMRT approach was associated with lower values of Dmax for the right optic nerve(0.75 Gy,t=3.266,P=0.010),Dmean for the right eyeball(2.24 Gy,t=2.351,P=0.043),Dmax for the spinal cord (1.92 Gy,t=2.828,P=0.020),Dmean for spinal cord (0.46 Gy,t=3.497,P=0.007)and Dmean for the left parotid(1.45 Gy,t=3.483,P=0.007). Conclusions Both RapidArc and dIMRT plans satisfied clinical requirements,but dIMRT plans were associated with superior homogeneity index, better protection of some OARs as well as greater monitor unit.

Key words: Nasopharyngeal neoplasm, Nasal Natural killer/T-cell, Lymphoma, Radiotherapy, Dosimetric comparison, RapidArc, Dynamic intensity modulated radiotherapy