Abstract:

Objective To explore whether type 2 diabetes is associated with risk of lymph node metastasis or liver metastasis in patients with colorectal cancer. Methods Medical records of 170 colorectal cancer patients were retrospectively analyzed using logistic regression to identify possible relationships of type 2 diabetes with lymph node metastasis or liver metastasis in patients with colorectal cancer. Results  Of the 170 patients，50 had type 2 diabetes，while 120 did not. The rate of lymph node metastasis was 52.0% among patients with type 2 diabetes and 43.3% among those without it（P>0.05）.  The degeree of lymph node metastasis was 17.01% among patients with type 2 diabetes and 7.05% among those without it （P<0.001）. The rate of liver metastasis was 20.0% among patients with type 2 diabetes and 8.3% among those without it （P<0.05）. Logistic regression identified type 2 diabetes as an independent risk factor of liver metastasis in patients with colorectal cancer. Conclusion The presence of type 2 diabetes appears to increase risk of liver metastasis in patients with colon cancer，without affecting risk of lymph node metastasis.

Key words: Colorectal neoplasm, Diabetes, Lymph node metastasis, Liver metastasis, Influence factors