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Chinese Journal of Oncology Prevention and Treatment ›› 2017, Vol. 9 ›› Issue (6): 469-472.doi: 10.3969/j.issn.1674-5671.2017.06.10

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Clinical significance of RAB22A expression in breast cancer

  

  • Online:2017-12-25 Published:2018-01-29

Abstract:

Objective To research the clinical significance of RAB22A expression in breast cancer. Methods Real-time PCR analysis was used to assess the expression of RAB22A mRNA in 60 breast cancer tissues and adjacent non-cancer tissues. Results RAB22A mRNA was expressed at high levels in tumors and low levels in adjacent non-cancer tissues [(4.9±1.1) vs (1.1±0.3),P<0.01]. RAB22A expression did not vary significantly with age,tumor invasion depth,ER status,PR status or HER-2 status(P>0.05),but it did vary significantly with lymph node metastasis (P<0.05). High expression of RAAB22A and the number of ymph node metastasis correlated with poor survival(P<0.05). Conclusions RAB22A is expressed at high level in breast cancer tissue,and high expression correlates with poor survival of breast cancer patients.

Key words: Breast neoplasmas, RAB22A, Metastasis, Prognostic