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中国癌症防治杂志

中国癌症防治杂志

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多西他赛、氟尿嘧啶联合奥沙利铂或顺铂治疗晚期鼻咽癌的临床对照研究

莫汉文;李丽萍;黄梨花;林钦雄;   

  1. 广东省东莞市人民医院肿瘤内科;
  • 收稿日期:2010-09-25 修回日期:2010-09-25 出版日期:2010-09-25 发布日期:2010-09-25

The effect of docetaxel and fluorouracil combined with oxaliplatin or cisplatin on advanced nasopharyngeal carcinoma

MO Han-wen,LI Li-ping,Huang Li-hua,et al.   

  1. (Oncology Department,People’s Hospital of Dongguan,Guangdong 523000,China
  • Received:2010-09-25 Revised:2010-09-25 Online:2010-09-25 Published:2010-09-25

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摘要： 目的评价多西他赛联合奥沙利铂、氟脲嘧啶(DOF方案)与多西他赛联合顺铂、氟脲嘧啶(DCF方案)组成的5d联合方案一线治疗晚期鼻咽癌的有效性和安全性。方法 60例患者分为A、B两组各30例。A组接受DOF方案治疗:多西他赛75mg/m2,d1;奥沙利铂135mg/m2,d1;氟脲嘧啶500mg/m2,d1～d5。B组接受DCF方案治疗:多西他赛75mg/m2,d1;顺铂20mg/m2,d1～d4;氟脲嘧啶500mg/m2,d1～d5。均每3周重复,至少应用2周期。结果 A组临床控制率、完全缓解率、部分缓解、中位治疗至进展时间、中位生存期以及1、2a生存率分别为86.67%、6.67%、60.00%、5.9mo、10.6mo、56.70%、15.35%。B组分别为83.33%、3.33%、53.33%、5.9mo、11.4mo、58.30%、12.47%。两组主要毒副反应为骨髓抑制、恶心呕吐和脱发等,但不严重。结论多西他赛联合奥沙利铂、氟脲嘧啶和多西他赛联合顺铂、氟脲嘧啶一线治疗进展期鼻咽癌疗效确切、毒副反应可接受。与最好的支持治疗相比联合化疗可延长患者生存期,提高生活质量。前者对生活质量的影响比后者轻。

关键词: 进展期鼻咽癌, 联合化疗, 疗效, 毒性

Abstract: Objective To evaluate the efficacy and safety of the 5-day chemotherapy by the combination of docetaxel,oxaliplatin and fluorouracil (DOF),or docetaxel,cisplatin and fluorouracil (DCF) as a first-line treatment for patients with advanced nasopharyngeal carcinoma.Methods60 patients with advanced nasopharyngeal carcinoma were randomly divided into group A and group B.Patients in group A (30 cases) were treated with DOF proposal as using docetaxel 75mg/m2 in d1,oxaliplatin 135mg/m2 in d1 and fluorouracil 500mg/m2 in d1～d5.Patients in group B (30 cases) were treated with DCF proposal as using docetaxel 75mg/m2 in d1,cisplatin 20mg/m2 in d1～d4 and fluorouracil 500mg/m2 in d1～d5.Both regimens were repeated once every 3 weeks for at least 2 cycles.ResultsThe clinical response rate,completed response rate,partial response rate,median progression time,median survival time,1-and 2-year survival rate were 86.67%,6.67%,60.00%,5.9mo,10.6mo,56.70% and 15.35% in group A respective1y,and 83.33%,3.33%,53.33%,5.9mo,11.4mo,58.30% and 12.47% in group B respectively.The main toxicities in two groups were bone marrow depression,nausea and hair loss,but all of them were mild and tolerable.ConclusionsThe combined chemotherapy of docetaxel,oxa1iplatin and fluorouracil,as well as docetaxel,cisplatin and fluorouracil are effective and tolerab1e for treating patients with advanced nasopharyngeal carcinoma.Comparing with best sustaining treatment,combined chemotherapy can prolong patient’s survival time and improve their life quality.In particular,the former regimen has less influence on life quality than the latter.

Key words: Docetaxel, Oxaliplatin, Fluorouracil, Cisplatin, Nasopharyngeal carcinoma