| 1Schuetz EG,Beck WT,Schuetz JD.Modulators and substrates of P-glycoproteinand cytochrome P4503Acoordinately up-regulate these proteinsin human colon carcino-ma cells[J].Mol Pharmacol,1996,49:311-318.
2Iwasaki K,Uno Y.Cynomolgus monkey CYPs:a comparison with human CYPs[J].Xenobiotica,2009,39(8):578-581.
3Agarwal V,Kommaddi RP,Valli K.Drug metabolism in human brain:high levels of cytochrome P4503A43in brain and metabolism of anti-anxiety drug alprazolam to its active metabolite[J].Plos One,2008,3(6):2337-2338.
4Burk O,Wojnowski L.Cytochrome P4503A and their regulation[J].Naunyn Schmiedebergs Arch Pharmacol,2004,369(1):105-124.
5刘茶珍,边建超,江峰,等.细胞色素P4503A4基因多态性与肝癌易感性研究[J].肿瘤,2003,23(1):7-10.
6Stevens JC,Hines RN,Gu C,et al.Developmental expression of the major human hepatic CYP3A enzymes[J].J Pharmacol Exp Ther,2003,307(2):573-582.
7Chowbay B,Zhou S,Lee EJ.An interethnic comparison of polymorphismsof the genes encoding drug-metabolizing enzymes and drug transporters:experience in singapore[J].Drug Metab Rev,2005,37(2):327-378.
8杨立群,李慎菁,曹云飞,等.慢性肝胆疾患P450同工酶CYP3A4表达的改变[J].第二军医大学学报,2002,23(4):407-409.
9Westlind-Johnsson A,Malmebo S,Johansson A,et al.Comparative analysis of CYP3A expression in human liver suggests only a minor role for CYP3A5in drug-metabolism[J].Drug Metab Dispos,2003,31(6):755-761.
10UtechtKN,Hiles JJ,Kolesar J.Effects of genetic polymorphisms on the pharmaco-kinetics of calcineurin inhibitors[J].Am J Health Syst Pharm,2006,63(23):2340-2348.
11Daly AK.Significance of the minor cytochrome P4503A isoforms[J].Clin Phar-macokinet,2006,45(1):13-31.
12Nagai F,Hiyoshi Y,Sugimachi K,et al.CytochromeP450(CYP)expression in human myeloblastic and lymphoidcell lines[J].Biol Pharm Bull,2002,25(3):383-385.
13Burk O,Koch I,Raucy J,et al.The induction of cytochrome P4503A5(CYP3A5)in the human liver and intestine is mediated by the xenobiotic sensors pregnane X receptor(PXR)and constitutively activated receptor(CAR)[J].J Biol Chem,2004,279(37):38379-38385.
14Balram C,Zhou Q,Cheung YB,et al.CYP3A5*3and*6single nucleotide pol-ymorphisms in three distinct Asian populations[J].Eur J Clin Pharmacol,2003,59(2):123-126.
15Saeki M,Saito Y,Nakamura T,et al.Single nucleotide polymorphisms and haplo-type frequencies of CYP3A5in a Japanese population[J].Hum Mutat,2003,21(6):653-654.
16Wojnowski L.Genetics of the variable expression of CYP3A in humans[J].Ther Drug Monit,2004,26(2):192-195.
17Wojnowski L,Turner PC,Pedersen B,et al.Increased levels of aflatoxin-albumin adducts are associated with CYP3A5polymorphisms in The Gambia,West Africa[J].Pharmacogenetics,2004,14(10):691-700.
18Smit P,van Schaik RH,van der Werf M,et al.A Common polymorphismin the CYP3A7Gene is associated with a nearly50%reduction in serum DHEAS levels[J].J Clin Endocrinol Metab,2005,90(9):5313-5316.
19Riffel AK,Schuenemann E,Vyhlidal CA,et al.Regulation of the CYP3A4and CYP3A7promoters by members of the nuclear factor I transcription factor family[J].Mol Pharmacol,2009,76(5):1104-1114. |
