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中国癌症防治杂志

中国癌症防治杂志

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血清DcR3水平与胃癌TNM分期的关系

杨梅松竹;廖芝玲;陈罡;罗殿中;   

  1. 广西医科大学病理学教研室;广西医科大学病理生理学教研室;
  • 收稿日期:2009-03-25 修回日期:2009-03-25 出版日期:2009-03-25 发布日期:2009-03-25

Correlation between elevated serum DcR3 and TNM staging in gastric carcinoma

YANG Mei-songzhu,LIAO Zhi-ling,CHEN Gang,et al.   

  1. (1 Department of Pathology,Guangxi Medical University,Nanning 530021,China;2 Department of pathophysiology,Guangxi Medical University
  • Received:2009-03-25 Revised:2009-03-25 Online:2009-03-25 Published:2009-03-25

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被引次数

8

摘要： 目的探讨血清诱捕受体3(DcR3)水平与胃癌TNM分期的关系。方法采用酶联免疫吸附试验(ELISA)检测34例胃癌患者、18例外科急性感染患者、28例正常人血清DcR3水平。结果胃癌患者血清DcR3水平明显高于正常人(P<0.01)和外科急性感染患者(P<0.01),外科急性感染患者与正常人比较差异无显著性(P>0.05)。胃癌TNMⅢ、Ⅳ期患者血清DcR3水平明显高于TNMⅠ、Ⅱ期患者(P<0.01);淋巴结转移患者明显高于无淋巴结转移患者(P<0.01),远处转移患者明显高于无远处转移患者(P<0.05),但与分化程度(P>0.05)、浸润深度(P>0.05)无关。结论血清DcR3水平与胃癌TNM分期有关,为术前评估胃癌临床分期和判断淋巴结及周围脏器切除范围提供理论依据。

关键词: DcR3, 胃肿瘤, 肿瘤分期, 血清

Abstract: Objective To investigate the correlation between serum decoy receptor 3(DcR3) and TNM staging in gastric carcinoma (GC).Methods Serum DcR3 levels were measured by using enzyme linked immunosorbent assay(ELISA) in 34 patients with GC,18 patients with nonmalignant conditions and 28 healthy individuals.Results The levels of serum DcR3 in GC were significantly higher than that in the control group(P<0.01) and the nonmalignant conditions(P<0.01),respectively. Serum DcR3 levels in GC in TNM stageⅢandⅣwere obviously higher than that in stageⅠandⅡ(P<0.01).In addition, patients with both lymph node metastasis and systemic metastasis showed significantly higher serum DcR3 levels compared to that without lymph node metastasis and systemic metastasis(P<0.01,P<0.05).But the levels of serum DcR3 had no correlation with differentiation grades and infiltrate depth(P>0.05,P>0.05).Conclusions Serum DcR3 levels were correlated significantly with TNM stage.This can help to evaluate the pre-operative clinical classification and decide the optimal extent of lymph node and adjacent organs dissection for gastric carcinoma.

Key words: DcR3, Gastric neoplasms, Neoplasm staging, Serum