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中国癌症防治杂志

中国癌症防治杂志 ›› 2012, Vol. 4 ›› Issue (3): 263-267.doi: 10.3969/j.issn.1674-5671.2012.03.14

• 循证医学 • 上一篇    下一篇

微粒体环氧化物水解酶EPHX1基因多态性与肝细胞性肝癌易感性的Meta分析

  

  1. 广西医科大学附属肿瘤医院肝胆外科
  • 出版日期:2012-09-25 发布日期:2012-10-15
  • 通讯作者: 吴飞翔 E-mail:wufxiang@yahoo.com.cn

The relationship between microsomal epoxide hydrolase (EPHX1) polymorphism and genetic susceptibility to hepatocellular carcinoma: A meta-analysis

  • Online:2012-09-25 Published:2012-10-15

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4

摘要： 目的 探讨微粒体环氧化物水解酶编码基因EPHX1多态性与肝细胞性肝癌（HCC）遗传易感性的关系。方法 按照制定的检索策略，检索相关数据库中的文献，获取有关EPHX1基因多态性与HCC易感性的病例-对照研究，提取相关数据进行Meta分析。以病例组和对照组基因型分布的比值比（OR）为效应指标，对纳入文献进行异质性检验，应用Stata12.0软件以不同合并模型对各研究原始数据进行Meta合并，计算合并效应量OR值及其95%可信区间（CI）。结果 共纳入9篇文献，EPHX1 337 T>C多态位点的共8个研究，累计病例584例，对照989例。等位基因比较模型（C vs T）的OR值为1.47（95%CI=1.26～1.72，P<0.001）；纯合子比较模型（CC vs TT）的OR值为1.88（95%CI=1.40～2.52， P<0.001）；隐性模型（CC vs CT/TT）的OR值为1.73（95%CI=1.36～2.21，P<0.001）。EPHX1 416A>G多态位点共6项研究，累计病例432例，对照699例。等位基因比较模型（G vs A）的OR值为0.75（95%CI=0.59～0.95，P=0.018）。结论 EPHX1 337T>C多态位点CC基因型与HCC易感性升高有关; 416A>G多态位点等位基因G可能降低HCC易感性，为保护基因型。

关键词: 肝肿瘤, 微粒体环氧化物水解酶, EPHX1, 遗传多态性, 肿瘤易感性

Abstract: Objective To explore the relationship between microsomal epoxide hydrolase（EPHX1）polymorphism and genetic sus-ceptibility to hepatocellular carcinoma（HCC）. Methods Both English- and Chinese-language databases were searched for relevant lit-erature on the relationship between EPHX1 polymorphism and HCC using a preformulated search strategy.Data on the association were evaluated using odds ratio（ORs）with 95% confidence intervals（CIs）， and heterogeneity of included studies was assessed. Meta-analysis of published data was carried out using Stata 12.0 software. Results Nine studies were included based on the selection crite-ria 8 studies，involving 584 cases and 989 controls，examined the EPHX1 polymorphism 337T>C.Significant increased risk of HCC was found using the additive model［C vs T OR（95%CI）=1.47（1.26~1.72），P<0.001］，homozygote comparison［CC vs TT OR（95%CI） =1.88（1.40~2.52），P<0.001］，and the recessive model［CC vs CT/TT OR（95%CI）=1.73（1.36~2.21），P<0.001］.A total of 6 studies in-volving 432 cases and 699 controls examined the EPHX1 polymorphism 416A>G.Markedly decreased risk of HCC was observed using the additive model［G vs A OR（95%CI）=0.75（0.59~0.95），P=0.018］. Conclusions The EPHX1 polymorphism 337T>C is associated with HCC，and the CC genotype appears to be a risk factor.In contrast，the G allele of the EPHX1 polymorphism 416A>G may de-crease HCC susceptibility and therefore constitute a protective factor against HCC.

Key words: Hepatocellular neoplasms, Microsomal epoxide hydrolase, EPHX1, Genetic polymorphism, Cancer susceptibility