关键词: 肺肿瘤, 非小细胞肺癌, HER-2, LRP, 基因表达, 免疫组织化学法, 预后

Abstract: Objective  To investigate associations between the expression of lung resistance protein（LRP） and human epidermal growth factor receptor 2（HER-2） and the clinico-pathological features of non-small cell lung cancer. Methods The two-step EnVision immunohistochemical method was used to measure the expression of HER-2 and LRP in 70 cases of non-small cell lung cancer tissues， and 35 corresponding adjacent normal lung tissues. Results Expression rates of HER-2 and LRP were significantly higher in cancer tissue （31.4% and 72.9%，respectively） than in adjacent normal lung tissue （P<0.05）. The expression rate of HER-2 was significantly higher in adenocarcinoma（46.0%） than in squamous cell carcinoma（15.2%； P<0.05）. However，HER-2 expression did not correlate with lymph node metastasis，pathologic classification or clinical staging（P>0.05）.The expression rate of LRP was similar in adenocarcinoma and squamous cell carcinoma（78.4 vs 66.7%，P>0.05），and LRP expression correlated with lymph node metastasis， pathologic classification， and clinical staging（P<0.05）. Conclusions HER-2 and LRP proteins are expressed to different degrees in non-small cell lung cancer.Assaying for both may be valuable for designing chemotherapy and predicting prognosis in non-small cell lung cancer.
 

Key words: Lung neoplasms, non-small cell lung cancer, HER-2, LRP, Gene expression, Immunohistochemistry, Prognosis