Abstract: Objective To explore possible relationships between lipid metabolism disorders and the occurrence of endometrial adenocarcinoma（EMA）. Methods A total of 68 patients with EMA and 61 control women were compared in terms of lipid metabolism indicators，fasting plasma glucose（FPG），fasting serum insulin（FINS） and homeostasis model assessment for insulin resistance（HOMA-IR）.Pooled odds ratios were estimated using non-conditional logistic regression to identify factors associated with risk of EMA and with clinicopathological features of the disease. Results The lipid indexes，FINS and HOMA-IR differed significantly between patients with EMA and controls（P<0.05）.However，triglyceride levels，FINS，and HOMA-IR were not significantly associated with clinicopathological features of EMA（P>0.05）. Conclusions EMA occurrence was associated with elevated body mass index， triglycerides，FINS，waist circumference，HOMA-IR.Elevated FINS，triglycerides and HOMA-IR may be useful as predictors of endometrial carcinoma.

Key words:  Uterine neoplasm, Metabolic syndrome, Insulin resistance