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25 June 2014, Volume 6 Issue 2 Previous Issue    Next Issue

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Research progress of cancer-testis antigen in ovarian carcinoma JIANG Jing-hong,CHANG Xiao-hong,CUI Heng 2014, 6 (2):  101-104.  doi: 10.3969/j.issn.1674-5671.2014.02.01 Abstract ( 374 )   PDF (349KB) ( 851 )   Save Related Articles | Metrics

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Research status of drug resistance mechanism of choriocarcinoma ZHAO Jing,XIANG Yang 2014, 6 (2):  105-108.  doi: 10.3969/j.issn.1674-5671.2014.02.02 Abstract ( 333 )   PDF (403KB) ( 837 )   Save Related Articles | Metrics

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Expression and significance of PRX2 and AKR1B10 during chemically induced hepatocarcinogenesis in mice HUANG Xue,XIE Yu-an,YANG Fan,LUO Min,ZHAO Wen-jie 2014, 6 (2):  109-114.  doi: 10.3969/j.issn.1674-5671.2014.02.03 Abstract ( 312 )   PDF (680KB) ( 600 )   Save Objective To explore the expression and significance of PRX2 and AKR1B10 during chemically induced hepatocar-cinogenesis in mice. Methods Primary hepatocellular carcinoma（HCC）was induced in 60 C57BL/6J mice by exposing them to a combination of diethylnitrosamines（DEN），carbon tetrachloride（CCl4）and ethanol. Another group of 30 mice received no drugs and served as a negative control.Mice were killed on weeks 4，8，12，16 and 20 and tissue samples were harvested for staining with hematoxylin and eosin.Samples were also analyzed by QPT-PCR and immunohistochemistry to detect changes in PRX2 and AKR1B10 mRNA and protein. Results In mice with chemically induced HCC，toxic hepatitis and acute hepatocellular necrosis were observed by week 4.By week 8，hepatocellular necrosis had gotten worse and liver fibrosis was detectable.Atypical hyperplasia was observable by week 12，pseudolobule by week 16 and hepatocellular carcinoma by week 20.Expression of PRX2 and AKR1B10 was significantly higher in the HCC animals than in control animals from week 4 to 20（P<0.05），and levels continued to increase with time.Levels were significantly higher in the HCC animals by week 20 than before chemical induction of HCC（P<0.05）.Expres-sion of PRX2 mRNA positively correlated with that of AKR1B10 mRNA（r=0.674，P=0.05）. Conclusion Overexpression of PRX2 and AKR1B10 may be early events during chemically induced hepatocarcinogenesis in mice and may promote hepatocarcinogenesis. Related Articles | Metrics

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Dynamics of DNA-dependent protein kinase expression in the development of platinum resistance and correlation with clinical factors SHI Li-jun,LI Meng-di,LI Li,WANG Qi 2014, 6 (2):  114-120.  doi: 10.3969/j.issn.1674-5671.2014.02.04 Abstract ( 379 )   PDF (702KB) ( 445 )   Save Objective To analyze the dynamics of DNA-dependent protein kinase（DNA-PKcs） expression in a nude mouse model of platinum resistance，as well as correlate the dynamics with clinicopathological characteristics of ovarian cancer patients，in order to develop an experimental system for individualized chemotherapy. Methods DNA-PKcs expression was measured by real-time fluores-cence quantitative reverse transcription-polymerase chain reaction（qRT-PCR）.Pearson correlation was used to examine associations between expression levels and clinical factors in patients with ovarian cancer.Kaplan-Meier analysis was used to examine association of DNA-PKcs expression with progression-free survival （PFS） and overall survival （OS）.Factors affecting patient survival were iden-tified by Cox regression. Result DNA-PKcs expression was significantly lower in transplanted platinum-resistant tumors than in platinum-sensitive controls（P=0.003）.Development of drug resistance was associated with a gradual decrease in DNA-PKcs expression，which remained low during the production of platinum-resistant tumor cells.Pearson analysis showed that DNA-PKcs expression correlated negatively with both patient response to platinum treatment and the level of platinum resistance（P=0.000）.Kaplan-Meier analysis showed significantly higher survival rates for patients at an early FIGO stage， patients without residual disease，patients who responded to primary platinum treatment，patients sensitive to platinum， and patients with high DNA-PKcs expression（P<0.05）.Cox regression identified two factors affecting survival time in patients with ovarian cancer：response to primary platinum treatment（P=0.047） and platinum resistance （P=0.047）.DNA-PKcs expression was significantly higher in patients who responded completely to platinum treatment than in patients with stable or progressive tumors（P=0.000）.Similarly，DNA-PKcs expression was significantly higher in platinum-sensitive patients than in platinum-resistant ones（P=0.000）. Conclusion The development of platinum resistance may be associated with a reduction in DNA-PKcs expression，suggesting that DNA-PKcs may be a useful biomarker of platinum resistance in ovarian cancer. Related Articles | Metrics

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Effect of silencing gene CDKN1A on radiosensitivity of radioresistant human nasopharyngeal carcinoma CNE-2R cell MA Jia-lin,GUO Ya,QU Song,ZHAO Wei,LI Ling,SU Fang,LI Ye,GE Lian-ying,ZHU Xiao-dong 2014, 6 (2):  121-126.  doi: 10.3969/j.issn.1674-5671.2014.02.05 Abstract ( 429 )   PDF (606KB) ( 575 )   Save Objective To investigate the relationship between the CDKN1A gene expression and the change of radiosensitivity of human nasopharyngeal carcinoma. Methods Lentiviralvector-mediated RNA interference（LV-CDKN1A-RNAi） targeting was constructed and transfected it to CNE-2R cells.CNE-2R cells transfected with LV-CDKN1A-RNAi were taken as experimental group，those transfectedwith control virus and without any treatment were taken as control group and blank group.The proliferation inhibitory rate was measured by CCK-8 assay.Colony formation assay was performed to determine the radiosensitizing effect.Cell cycle distribution was analyzed by flow cytometry. Results The stably silenced expression of CDKN1A CNE-2R cell line was established.CCK-8 assay showed that the growth of CNE-2R cell of the experimental group was inhibited after 6 Gy irradiating，which was closely related to growth time.The results of colony formation assay showed that the radiosensitivity of CNE-2R cell of the experimental group was more enhance（SER=1.24） than the other groups.Comparing with control group，cell cycle distribution showed that the cell distribution of G0 /G1 and G2 /M cycle in the experiment group was significantly changed before and after 6 Gy irradiating. Conclusions Silencing gene CDKN1A may enhance the radiosensitivity of CNE-2R cells of human nasopharyngeal carcinoma，which maybe used as a thera-peutic target for nasopharyngeal carcinoma. Related Articles | Metrics

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Using gene-set enrichment pathway analysis to identify signaling pathways and functional single nucleotide polymorphisms related to multi-drug resistance in epithelial ovarian cancer CAI Zu-ai,WANG Qi,ZHANG Wei,LI Li,YIN Fu-qiang 2014, 6 (2):  127-132.  doi: 10.3969/j.issn.1674-5671.2014.02.06 Abstract ( 433 )   PDF (386KB) ( 822 )   Save Objective This bioinformatics study aimed to explore signaling pathways and functional single nucleotide polymorphisms （SNPs） related to multidrug resistance（MDR） in epithelial ovarian cancer. Methods Patients with ovarian cancer treated by platinum and paclitaxel after primary surgery were selected from the SNP array（GSE13813） in the Gene Expression Omnibus （GEO） dataset. PLINK software and allelic tests were applied to identify SNPs significantly related to MDR（P<0.05），which were further analyzed online using gene-set enrichment pathway analysis（GSEA） in WebGestalt and DAVID. SciMiner was used to search for all genes potentially related to MDR in patients with epithelial ovarian cancer，and the corresponding functional pathways were explored using WebGestalt and DAVID.Finally，the on-line software Snpfunc was used to predict functions of SNPs in MDR-related pathways as well as of their partners in linkage disequilibrium. Results GSEA of 4978 significant SNPs from 22 platinum-resistant and 51 platinum-sensitive patients identified cell adhesion molecules and calcium-and ErbB-dependent signaling pathways as being potentially related to MDR.Literature analysis supported the association between the ErbB signaling pathway and MDR.Function prediction suggested that 11 functional SNPs may modify gene function by causing aberrant splicing or amino acid substitutions，potentially affecting response to combination chemotherapy. Conclusion Using GSEA，we identified three possible MDR-related signaling pathways and 11 functional SNPs that may help predict responses to platinum-based combination chemotherapy for epithelian ovarian cancer. These findings should be confirmed in future studies. Related Articles | Metrics

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Lentivirus-mediated LKB1 gene expression in HEC-1A endometrial cancer cells TANG Qiao-qiao,SONG Yue,LONG Yin,ZHANG Jie-qing,SONG Hong-lin,ZHAO Bing-bing 2014, 6 (2):  133-138.  doi: 10.3969/j.issn.1674-5671.2014.02.07 Abstract ( 333 )   PDF (482KB) ( 618 )   Save Objective To investigate lentivirus-mediated LKB1 gene overexpression in HEC-1A endometrial cancer cells as a basis for future research. Methods The LKB1 gene was subcloned by RT-PCR from a cDNA plasmid into a lentiviral pWPI expression vector， generating the plasmid LKB1/pWPI．This plasmid was co-transfected into 293T cells together with the packaging plasmid pCMV-Dr8.74 and pMD2.G.The recombinant virus was used to infect HEC-1A cells，and LKB1 expression was measured using real-time quantitative PCR（qRT-PCR） and Western blotting. Results We succeeded in constructing the recombinant plasmid LKB1/pWPI and packaging it into lentiviral particles in 293T cells.This virus infected HEC-1A cells efficiently， leading to higher LKB1 expression than in the parental cells or untransfected controls（P<0.01）. Conclusion The LKB1 gene has been incorporated into a lentiviral expression vector， allowing studies of its effects on the development of endometrial cancer. Related Articles | Metrics

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Expression and clinical significance of FKBP12 and FKBP52 in primary hepatocellular carcinoma LI Chuan-wei,WANG Xue-di,ZHANG Zhi,LI Dong-dong,YU Guo-tang,XU-Jing 2014, 6 (2):  138-142.  doi: 10.3969/j.issn.1674-5671.2014.02.08 Abstract ( 392 )   PDF (406KB) ( 717 )   Save Objective To analyze the expression of FKBP12 and FKBP52 in hepatocellular carcinoma（HCC） and explore its rela-tionship with clinicopathological factors. Methods Expression of FKBP12 and FKBP52 was measured in 60 samples of HCC tissue， 60 samples of normal adjacent tissue，10 samples of hepatic hemangioma and 10 cases of normal liver tissue.Expression was analyzed using the immunohistochemical streptavidin-peroxidase method and correlated with clinicopathological factors. Results Expression of FKBP12 was detected in 66.7% of HCC samples，a rate significantly higher than the 30.0% of adjacent tissues，20.0% of liver hemangioma and 40.0% of normal liver tissues（P<0.05）.The rate of FKBP52 expression was significantly higher in HCC tissues （63.3%） than in adjacent tissues （26.7%） and normal liver tissues （20.0%），but similar to the rate in liver hemangioma （40.0%）.Rates of FKBP12 and FKBP52 expression were similar in HCC tissues.There was no significant relationship between FKBP12 expression in HCC tissue and patient age，gender，cirrhosis， or hepatitis B virus infection，but expression was related to tumor size，pathology grade，and serum AFP level.There was no significant relationship between FKBP52 expression in HCC tissue and age，gender， tumor size，cirrhosis， or serum AFP level（P>0.05），but expression was related to pathology grade and hepatitis B virus infection（P<0.05）. Conclusion Expression of FKBP12 and FKBP52 correlate closely with incidence of HCC.FKBP12 may be involved in the proliferation and differentiation of tumor cells，and it may contribute to elevated serum AFP levels in liver cancer patients.FKBP52 may contribute to the differentiation of hepatocellular carcinoma and may participate in cellular processes in liver infected by hepatitis B virus. Related Articles | Metrics

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Expression and clinical significance of tumor-associated CD34 fibroblasts and α-SMA in nasopharyngeal carcinoma interstitium DANG Yang,MO Li-gen,LUO Yuan,ZHANG Kun,SUN Yi 2014, 6 (2):  143-147.  doi: 10.3969/j.issn.1674-5671.2014.02.09 Abstract ( 409 )   PDF (503KB) ( 634 )   Save Objective To investigate the relationship of tumor-associated CD34 fibroblasts and α-smooth muscle actin（α-SMA）in the nasopharyngeal carcinoma interstitium with invasion and metastasis by nasopharyngeal carcinoma. Method Expression of CD34 and α-SMA was measured by immunohistochemistry in 75 patients with nasopharyngeal carcinoma and 20 patients with chronic inflammation of the nasopharyngeal mucosa.Expression levels were compared with clinicopathological features of nasopharyngeal carcinoma using the supervised two-step method. Result Of the 75 cancer patients，7（9.33%） showed CD34 expression only in blood vessels and not in fibroblasts.In contrast，17 of 20 control patients（85.00%） showed CD34 expression not only in fibroblasts but also in small blood vessels of chronically inflamed tissue.These expression differences between the two groups were significant （χ2=31.542，P<0.01）.The proportion of patients expressing α-SMA was significantly higher in the nasopharyngeal carcinoma group（61/75， 81.33%） than in the control group（2/20，10.00%； χ2=51.263，P<0.01）. Correlation analysis of α-SMA expression with clinical and pathological features of nasopharyngeal carcinoma patients showed that the protein level was not related to age or gender （P>0.05）， but it was associated with clinical stage，T stage，lymphatic metastasis and distant metastasis（P<0.05）. Conclusion Fibroblasts in the nasopharyngeal carcinoma interstitium show phenotypic differences from the fibroblasts of chronically inflamed nasopharyngeal mucosa.These changes include lack of CD34 expression and overexpression of α-SMA.Expression levels of α-SMA appear to be related to nasopharyngeal carcinoma metastasis. Related Articles | Metrics

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Lipid metabolism disorders as risk factors for endometrial adenocarcinoma CHEN Hai-yan,XIE CHENG-hong,SONG Hong-lin,ZHANG Jie-qing 2014, 6 (2):  148-152.  doi: 10.3969/j.issn.1674-5671.2014.02.10 Abstract ( 308 )   PDF (311KB) ( 493 )   Save Objective To explore possible relationships between lipid metabolism disorders and the occurrence of endometrial adenocarcinoma（EMA）. Methods A total of 68 patients with EMA and 61 control women were compared in terms of lipid metabolism indicators，fasting plasma glucose（FPG），fasting serum insulin（FINS） and homeostasis model assessment for insulin resistance（HOMA-IR）.Pooled odds ratios were estimated using non-conditional logistic regression to identify factors associated with risk of EMA and with clinicopathological features of the disease. Results The lipid indexes，FINS and HOMA-IR differed significantly between patients with EMA and controls（P<0.05）.However，triglyceride levels，FINS，and HOMA-IR were not significantly associated with clinicopathological features of EMA（P>0.05）. Conclusions EMA occurrence was associated with elevated body mass index， triglycerides，FINS，waist circumference，HOMA-IR.Elevated FINS，triglycerides and HOMA-IR may be useful as predictors of endometrial carcinoma. Related Articles | Metrics

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Diagnostic value of diffusion-weighted magnetic resonance and of different values of the apparent diffusion coefficient for recurrent nasopharyngeal carcinoma WANG Chen,SU Dan-ke,LIU Li-dong，,XIE Dong,LIU Yu,LIU Si-yuan,HUANG Wei-li 2014, 6 (2):  153-158.  doi: 10.3969/j.issn.1674-5671.2014.02.11 Abstract ( 302 )   PDF (547KB) ( 599 )   Save Objective To investigate the diagnostic value of diffusion-weighted magnetic resonance imaging（MRI） and different apparent diffusion coefficients for primary and recurrent nasopharyngeal tumors. Method A total of 103 newly diagnosed patients prior to treatment，39 patients who experienced local recurrence after radiotherapy and 51 patients who experienced fibrosis after radiotherapy underwent routine，enhanced and diffusion-weighted MRI sequence scanning（b=0.800 s/mm2）.The apparent diffusion coefficient（ADC） obtained for each group of patients was compared using ANOVA，and receiver operating characteristic（ROC） curves were plotted to determine the threshold ADC value for confirming a diagnosis of nasopharyngeal carcinoma and for diagnosing recurrence. The diagnostic sensitivity，specificity and Youden index were compared for routine and diffusion-weighted MRI. Results The ADC value differed significantly between the fibrosis group and the two other groups（P<0.05），but not between the recurrence group and newly diagnosed group（P>0.05）.Based on a diagnostic threshold of 0.851×10-3 mm2/s from the newly diagnosed group，the sensitivity， specificity and Youden index were 98.0%，94.9%，and 0.929 for the newly diagnosed group and 76.9%，98.0%，and 0.749 for the recurrence group.Based on a diagnostic threshold of 0.887×10－3 mm2/s，the sensitivity，specificity and Youden index of the recur-rence group were 87.2%，94.1% and 0.813. Conclusions Diffusion-weighted MRI shows promise for detecting and diagnosing new and recurrent nasopharyngeal carcinoma；its diagnostic efficiency was higher than that of conventional MRI in our cohort.The ADC threshold value obtained from the recurrence group showed higher performance for diagnosing recurrent tumor than did the ADC value obtained from the newly diagnosed group. Related Articles | Metrics

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Comparison of CEUS and contrast-enhanced CT for diagnosis of <2 cm hepatocellular carcinoma LU Jing-ning,PENG Min-hao,XIAO Kai-yin,PENG Tao,PENG Jin-bo,YANG Hong 2014, 6 (2):  159-163.  doi: 10.3969/j.issn.1674-5671.2014.02.12 Abstract ( 320 )   PDF (438KB) ( 616 )   Save Objective To investigate the diagnostic value of CEUS for small （<2 cm） hepatic nodules detected by surveillance ultrasound in patients infected with hepatitis B virus（HBV）. Methods A total of 77 liver cirrhosis patients with 86 small hepatic nodules（<2 cm） were examined by both CEUS and contrast-enhanced CT.Histopathology based on biopsy or surgery served as the diagnostic gold standard for comparing the sensitivity，specificity，and accuracy of CEUS and CT. Results Sensitivity，specificity，and accuracy were 81.0%，88.6%，and 84.9% for CEUS，similar to the corresponding values of 76.2%，90.9%，and 83.7% for contrast-enhanced CT.Two nodules were correctly diagnosed by CEUS but were misdiagnosed by CT. Conclusion CEUS shows similar ability as contrast-enhanced CT to characterize small nodules（<2 cm） detected by surveillance in patients infected with hepatitis B virus. However，CEUS may be particularly helpful for diagnosing suspicious lesions and for performing follow up. Related Articles | Metrics

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Predictors and prognosis of patients who undergo delayed extubation after lobectomy under general anesthesia HE Sheng,PAN Ling-hui,LIN Fei,GE Wan-yun,Dai Hui-jun,LI Wei 2014, 6 (2):  163-166.  doi: 10.3969/j.issn.1674-5671.2014.13 Abstract ( 436 )   PDF (285KB) ( 577 )   Save  Objective To determine independent predictors of delayed postoperative extubation in patients undergoing lung cancer surgery. Method Records were retrospectively reviewed for 706 lung cancer patients who underwent lung resection under general anesthesia at the Affiliated Tumor Hospital of Guangxi Medical University from October 2008 to October 2013.Data were extracted on general patient condition，preoperative examination results，intra-and postoperative management， and other relevant factors.Uncon-ditional logistic regression was used to identify whether any of these indicators predicted delayed postoperative extubation.Then we compared incidence of postoperative complications and hospitalization time in the patients who underwent delayed extubation（n=51） and those who did not （n=655）. Result The incidence of delayed extubation in 706 lung cancer patients was 7.2%.Postoperative complications occurred in 18 of 51 patients in the delayed extubation group（35.3%），while they occurred in only 102 of 655 patients in the normal extubation group（15.6%，P＜0.05）.Length of hospitalization was significantly longer in the delayed extubation group （17.5±6.2 days） than in the normal extubation group（14.1±7.3 days，P<0.05）.Unconditional logistic regression identified five of the 25 variables tested as independent risk factors for delayed extubation：age>60 years（OR=6.568，P<0.001），prolonged single-lung ventilation（OR=1.268，P=0.047）， male gender（OR=1.511，P=0.046），urinary flow<17 ml/h（OR=1.456，P=0.032），and reduced lung function（OR=1.579，P=0.033）. Conclusions Delayed postoperative extubation after lobectomy in lung cancer patients is associated with longer hospital stay and greater risk of postoperative complications. This delay is caused by multi-factor synergism，related mainly to poor preoperative lung function，older age，male gender，poor urinary function，prolonged single-lung ventilation and other relevant factors. Related Articles | Metrics

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Efficacy and safety of combining infusion of antigen-activated，TCR gene-transfected memory T cells combined with chemotherapy for treating advanced non-small cell lung cancer resistant to EGFR-TKIs JIANG Guan-ming,YUAN Ling-qin,JIA Yun,LIN Shun-huan,CAI Yan-min,LIU Chun,WU Yi-fen,WANG Zai-guo,HUANG Shu-lin 2014, 6 (2):  167-171.  doi: 10.3969/j.issn.1674-5671.2014.02.14 Abstract ( 365 )   PDF (313KB) ( 723 )   Save  Objective To examine whether infusion of antigen-activated memory T cells transfected with TCR genes alters the clinical efficacy and toxicity of pemetrexed-cisplatin combination chemotherapy to treatin the treatment of advanced non-small cell lung cancer resistant to EGFR-TKIs. Methods A total of 41 patients with non-small cell lung cancer were randomized into a group （n=20） that received standard chemotherapy involving a 3-week regime of pemetrexed（500 mg/m2） and cisplatin （75 mg/m2），or into a group（n=21） that received the same chemotherapy after harvesting， culturing and intravenously infusing DC-activated T cells.Curative effects，immune function， quality of life and adverse reactions were compared between the two treatments. Results Combining infu-sion of DC-activated T cells with chemotherapy significantly increased serum populations of CD3+，CD4+，CD8+，CD95+，and CD122+ cells，as well as the CD4+/CD8++ratio.Combination therapy and standard chemotherapy alone gave similar overall response rates of 33.33% and 30.00% （P>0.05），respectively，but combination therapy led to a significantly higher disease control rate（76.19% vs 60.00%， P<0.05），longer median progression-free survival （7.1 vs 3.7 months， P<0.05），and a higher rate of improvement in KPS （karnofsky performance status）improvement rate（85.71% vs 45.00%， P<0.05）.At the same time，combination therapy was associated with much lower rates of neutropenia （46.6% vs 75.0%），nausea （52.4% vs 90.0%） and fatigue （23.8% vs 65.0%，P<0.05）. Conclusion Combining infusion of antigen-activated memory T cells with pemetrexed and cisplatin chemotherapy improves therapeutic response and immune function while also reducing side effects when treating patients with advanced non-small cell lung carcinoma resistant to EGFR-TKIs.This promising therapeutic approach should be explored further. Related Articles | Metrics

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Clinical observation of combined chemotherapy between irinotecan plus cisplatin regimen and paclitaxel plus cisplatin regimen in second-line treatment for small cell lung cancer JU Wen-cui,WANG Mu-min,LUO Xiao-yong 2014, 6 (2):  172-174.  doi: 10.3969/j.issn.1674-5671.2014.02.16 Abstract ( 387 )   PDF (275KB) ( 635 )   Save Related Articles | Metrics

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Efficacy of hyperthermia combined with radiotherapy and chemotherapy for non-small-cell lung cancer WEN Ben,XIE Mei-qiang,ZHENG Wen-tao,LIU Chu-ji 2014, 6 (2):  175-177.  doi: 10.3969/j.issn.1674-5671.2014.02.16 Abstract ( 231 )   PDF (270KB) ( 457 )   Save Related Articles | Metrics

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The application of granulocyte colony stimulating factor in tumor patients receiving chemotherapy GU Yu-lan 2014, 6 (2):  177-180.  doi: 10.3969/j.issn.1674-5671.2014.02.17 Abstract ( 303 )   PDF (313KB) ( 688 )   Save Related Articles | Metrics

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Results and analysis of 20 472 women breast screening in nanning city TANG Wei,LIU Jian-lun,YANG Hua-wei,LAI Shao-lv,JIANG Yi,HUANG Zhen,WEI Wei 2014, 6 (2):  180-182.  doi: 10.3969/j.issn.1674-5671.2014.02.18 Abstract ( 328 )   PDF (272KB) ( 640 )   Save Related Articles | Metrics

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Application of evidence-based nursing in perioperative period of laparoscopic radical gastrectomy HU Huang-he,W Shan 2014, 6 (2):  183-185.  doi: 10.3969/j.issn.1674-5671.2014.02.19 Abstract ( 298 )   PDF (298KB) ( 656 )   Save Related Articles | Metrics

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Application of case teaching method in the NCCN guide teaching of medical oncology ZHAO Wen-hua,ZHOU Shao-zhang,SONG Xiang-qun,ZENG Ai-pin,YU Qi-tao 2014, 6 (2):  185-188.  doi: Abstract ( 232 )   PDF (326KB) ( 793 )   Save Related Articles | Metrics

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Application of action oriented teaching method in the teaching of clinical microbiology laboratory practice in tumor CHEN Yan-hua,CHEN Ling,JIANG Zong-wei,LU Yi-ping 2014, 6 (2):  188-191.  doi: 10.3969/j.issn.1674-5671.2014.02.21 Abstract ( 275 )   PDF (304KB) ( 648 )   Save Related Articles | Metrics

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Application of laparoscopic operation system in clinical teaching of gastrointestinal tumor surgery MO Xian-wei,YANG Yang,LAI Hao 2014, 6 (2):  191-191.  doi: 10.3969/j.issn.1674-5671.2014.02.22 Abstract ( 276 )   PDF (237KB) ( 641 )   Save Related Articles | Metrics

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Combined treatment of bone metastasis in breast cancer JI Yong-ling,DU Xiang-hui 2014, 6 (2):  193-197.  doi: 10.3969/j.issn.1674-5671.2014.02.23 Abstract ( 309 )   PDF (300KB) ( 653 )   Save Related Articles | Metrics

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Application of CA125 and HE4 in the diagnosis of endometrial carcinoma WANG Hui-ru,WANG Huan-ni,MO Ling-zhao 2014, 6 (2):  198-201.  doi: 10.3969/j.issn.1674-5671.2014.02.24 Abstract ( 408 )   PDF (294KB) ( 554 )   Save Related Articles | Metrics

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Anti-viral therapy and viral hepatitis-associated hepatocellular carcinoma CHEN Zhi-gang,HUANG Chao-yuan,LIAN Fang,ZHAO Yin-nong,WU Guo-bin 2014, 6 (2):  201-204.  doi: 10.3969/j.issn.1674-5671.2014.02.25 Abstract ( 290 )   PDF (374KB) ( 525 )   Save Related Articles | Metrics

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Advances in the diagnosis and operation treatment of lateral skull base neoplasm SUN Yi,MO Li-gen 2014, 6 (2):  205-207.  doi: 10.3969/j.issn.1674-5671.2014.02.26 Abstract ( 271 )   PDF (293KB) ( 649 )   Save Related Articles | Metrics

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Research advance of toxic reactions of radiotherapy and chemotherapy treated by chinese medicine ZHANG Qian-qian,YANG Li-na,SONG Hong-tao 2014, 6 (2):  208-210.  doi: 10.3969/j.issn.1674-5671.2014.02.27 Abstract ( 323 )   PDF (303KB) ( 700 )   Save Related Articles | Metrics

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Application in evaluation of contrast-enhanced ultrasound in hepatic focal masses LI Ya-yi,LI Hang,ZHAO Sheng-fa 2014, 6 (2):  211-214.  doi: 10.3969/j.issn.1674-5671.2014.02.28 Abstract ( 282 )   PDF (280KB) ( 590 )   Save Related Articles | Metrics

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Nursing progress of complication in tumor chemotherapy patients with PICC tube LAO Yong-cong,JIANG Jin-fang 2014, 6 (2):  215-217.  doi: 10.3969/j.issn.1674-5671.2014.02.29 Abstract ( 364 )   PDF (295KB) ( 562 )   Save Related Articles | Metrics

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Genome-wide and differential proteomic analysis of hepatitis B virus and aflatoxin B1 related hepatocellular carcinoma inGuangxi，China Qi Lu-nan 2014, 6 (2):  217-218.  doi: 10.3969/j.issn.1674-5671.2014.02.30 Abstract ( 252 )   PDF (238KB) ( 765 )   Save Related Articles | Metrics