Abstract:

Objective Our study aimed to analyze the pathological features and prognostic factors of patients with gastric carcinoma with thrombocytosis. Methods Clinical data were analyzed for gastric carcinoma patients treated at our hospital from 2013 to 2015. A total of 100 patients were divided into two groups depending on whether they suffered from thrombocytosis：Group A，51（PLT≥400×10⁹/L） and Group B，49 （PLT ＜400×10⁹/L）. The prognostic factors were analyzed by multivariate Cox regression. Results Group A patients had higher percentage of tumors with diameter >5 cm and later tumor stage than Group B （P＜0.05）. Type of organization，histological differentiation，vascular tumor emboli and lymph node metastasis did not differ significantly between the groups（P＞0.05）. Group A patients had lower levels of PT，and higher levels of D-D and FIB than Group B patients （P＜0.05）. Group A showed lower 2-year survival rate （64.71% vs 83.67%，χ²=4.439，P=0.035）. Univariate analysis identified tumor size，tumor stage，platelet increase，age，and postoperative adjuvant chemotherapy as independent prognostic factors. Multivariate analysis identified clinical stage（HR=1.135，95%CI：1.077~1.196，P＜0.001），thrombocytosis（HR=1.443，95%CI：1.298~1.604，P＜0.001）and postoperative chemotherapy（HR=0.822，95%CI：0.754~0.896，P＜0.001） as independent prognostic factors of gastric cancer patients. Conclusions Thrombocytosis is an independent risk factor for the prognosis of patients with gastric cancer. Gastric carcinoma combined with thrombocytosis indicates poor prognosis.

Key words: Gastric neoplasms, Thrombocytosis, Coagulation function, Clinical pathology, Prognosis