Abstract:

Objective To investigate the effects of the total care and treatment（TCT） model in the diagnosis and treatment of hepato-cellular carcinoma in Guangxi. Methods Medical records were retrospectively analyzed for 1，810 patients who were diagnosed and initially treated at Affiliated Tumor Hospital of Guangxi Medical University  and Guigang People's Hospital between January 2012 and December 2015. Patients were allocated to the TCT group or conventional diagnosis and treatment group  based on the diagnosis and treatment model that they received. Baseline characteristics and prognosis were compared between the two groups. Results A total of 1，054 patients in TCT group and 756 patients in conventional diagnosis and treatment group. While 784 patients in TCT group and 556 patients in con-ventional diagnosis and treatment group underwent hepatectomy or radiofrequency ablation.Among patients who underwent hepatectomy or radiofrequency ablation，1 and 2 years recurrence rates were similar in two groups.Treatment rates after recurrence at 1 or 2 years were higher in the TCT group than in the conventional group（100% vs 57.63%，χ²=9.836，P=0.020；100% vs 56.77%，χ²=7.679，P=0.060）. For the entire cohort，1 or 2 years cumulative survival was higher in the TCT group than in the conventional group （83.20% vs 79.28%，P<0.05；67.12% vs 59.31%，P＜0.05）. Conclusion The TCT model，a sequential individualized treatment model for hepatocellular carcinoma，may be associated with better prognosis than conventional diagnosis and treatment for hepatocellular carcinoma patients in Guangxi.

Key words: Liver neoplasms , Total care and treatment model, Recurrence, Prognosis