Abstract: Objective To investigate the incidence of catheter⁃related dermatological adverse reactions in cancer patients undergoing central venous infusion of Utidelone and the influencing factors. Methods A retrospective analysis was conducted on clinical data from cancer patients who received Utidelone infusions via peripherally inserted central catheter (PICC) or totally implanted access port (TIAP) at Sun Yat⁃sen University Cancer Center between March 2021 and March 2024. To investigate the factors influencing cathete⁃related dermatological adverse reactions, univariable analysis and binary Logistic regression were employed. Results Among the 205 patients included in study, 40 (19.5%) experienced catheter⁃related dermatological adverse reactions, 29 (72.5%) of these cases resulting in the unplanned removal of the infusion device. Univariable analysis identified a significant association between the occurrence of catheter⁃related dermatological adverse reactions and factors such as alcohol consumption history, total cycles of Utidelone treatment, infusion method, type of catheter, and catheter insertion vein(all P<0.05). Further Logistic regression analysis identified several risk factors for catheter⁃related dermatological adverse reactions, including the alcohol consumption history (OR=8.112, 95%CI: 1.616-40.728), the more total cycles of Utidelone treatment (OR=1.212, 95%CI: 1.043-1.409), and catheter insertion via the internal jugular vein for TIAP (OR=4.816, 95%CI: 1.136-20.425) or brachial vein for PICC (OR=34.171, 95%CI: 2.136-546.573). Conclusions The incidence of catheter⁃related dermatological adverse reactions is relatively high in patients receiving Utidelone via central venous infusion, potentially influenced by alcohol consumption history, the total cycles of treatment, and the choice of insertion vein. It is recommended that healthcare providers enhance monitoring of skin around the catheter site and develop preventive strategies targeting these influencing factors to reduce the incidence of adverse reactions.

Key words: Cancer, Central venous, Utidelone, Catheter?related dermatological adverse reactions, Influencing factors