Abstract: Aim:To explore the expression and its clinicopathological implications of human 8-oxoGuanine DNA glycosylase-1 (hOGG1) in hepatocellular carcinoma(HCC) and cirrhotic tissues.Methods:hOGG1 expression was detected by immuneohistochemical EnVision method on liver tissues of non-HCC controls(n =41),cirrhotic(n =51) and HCC tissues(n =99 ).Results: There were three types of hOGG1 positive staining in HCCs:nuclear,cytoplasmic and mixed.The expression levels of hOGG1 in nucleus was significantly higher in HCCs than that in cirrhosis and controls and significantly higher in cirrhosis than that in controls(P<0.01).The expression of hOGG1 was not associated with the clinicopathological factors in HCCs(P>0.05 ).Multiplicity analysis indicated that hOGG1 expression in nucleus was related to ALT(OR = 1.022,P = 0.041),hOGG1 expression in cytoplasm was related to T bili(OR = 1.155,.P = 0.018).Conclusion:During hepatocarcinogenesis,the expression pattern of hOGG1 in liver cell nucleus might reflect the status of oxidative stress in each stage thus has etiology implications.

Key words: Human 8-oxoGuanine DNA glycosylase-1(hOGG1), Hepatocellular carcinoma, Immunohistochemistry