Abstract: Objective To evaluate the prognostic and cosmetic effects of breast-conserving therapy on patients with breast cancer.Methods Data of relapse,metastasis,survival and cosmetic from 176 patients with breast cancer received breast-conserving therapy were analyzed retrospectively.All the patients were in clinical stage 0~IIa,with single lesion in non-areola area.Lumpectomy was adopted with negative margin,followed by 50Gy radiation on whole breast and 10Gy on tumor-bed.Besides,patients carrying invasive breast cancer were given chemotherapy,and those with positive estrogen and/or progesterone receptor were given endocrine therapy.Results All the patients were followed up for a median period of 47.4 months(18～162 months).Ipsilateral breast tumor recurrence(IBTR) was found in 7 cases,distant metastasis was found in 8 cases and 3 of which were dead.The cosmetic results were evaluated according to the criteria of JCRT(Joint Center for Radiation Therapy).169 patients were classed into three grades:good(62.7%),fair(36.1%) and poor(1.2%).138 cases of them were followed up over 3 years.The 3-year overall survival rate was 99.28%,the disease free survival rate was 94.20%.Conclusions Breast-conserving treatment for breast cancer in stage 0~IIa is feasible.The strict and regulated approach is crucial for guaranteeing the success of treatment.

Key words: Breast-conserving therapy, Breast cancer, Surgery, Prognosis