Abstract: Objective To observe the effects and toxicity of Herceptin-combine Vinorelbine and other drug treatment on Her-2 over-expressing metastatic breast cancer.Methods Treatment consisted of Vinorelbine(25mg/m2 on day 1 and day 5 respectively),Trastuzumab(4mg/kg on day 0,followed by 2mg/kg weekly),Cisplantin(20mg/m2 on day 1~3) and Fluorouracil(1.0g on day 1~3).Results The overall response rate was 70%,including 6 cases(30%) complete and 8 cases(40%) partial response.Median survival was 15 months.Main toxicity was the degree III~IV of neutropenia(15/20) and secondary fever(6/15).Only one patient showed asymptomatic degree II of cardiac toxicity.Conclusion Herceptin-combined chemotherapy for treating Her-2 over-expressing metastatic breast cancer is safe and reliable,with significant efficacy.

Key words: Breast tumor, Chemotherapy, Herceptin, Targeted therapy