Abstract: Objective To explore the efficacy of different interventions on immune functions of the patients with anxiety and hepatocellular carcinoma(HCC) after operation.Methods Patients with HCC were assessed by self-rating anxiety scale(SAS),then 132 cases were selected into anxiety group(group A) and the matched 132 cases without anxiety were into the control group(group B).Group A and B were further randomly divided into four subgroups,namely psychological plus drug group,psychological group,drug group and non-intervention group.The levels of immunosuppressive acidic protein(IAP) and interleukin-6(IL-6) from each group before and 1-,4-,7-,14-,30-day after operation were compared.Results The preoperative levels of IAP and IL-6 in group A were significantly higher than that in group B,and the differences were statistically significant(P<0.01).Among the subgroups of groups A,the 1-,4-,7-,14-and 30-day postoperative levels of IAP and IL-6 were lower in psychological plus drug group and psychological group than that in drug group and non-intervention group(P<0.05 or P<0.01).Among the subgroups of group B,the differences of postoperative level of IAP and IL-6 were without statistically significant(P>0.05).Conclusions The preoperative anxiety of patient with HCC directly involves in suppression of immune function,and it has synergistic effect with surgery attack.Both of psychological intervention alone and psychological plus drug intervention can regulate patient's immune function and promote postoperative recovery.

Key words: Hepatocellular carcinoma, Anxiety, Immune function, Immunosuppressive acidic protein(IAP), Interleukin-6(IL-6)