Abstract: Objective To investigate the curative effect and adverse reaction of concurrent chemoradiotherapy (CCRT) on intermediate and advanced cervical cancer.Methods136 patients with intermediate or advanced cervical cancer were randomly divided into CCRT group and radiotherapy group,each group had 68 patients.Radiotherapy for both groups was by using high dosage rate of 192Ir on intracavity and external portion.Chemotherapy for the patients in CCRT group was by using three cycles of Cisplatin plus 5-FU.ResultsTotal effective rates in CCRT group and radiotherapy group were 95.6% and 83.8% respectively (χ2=5.096,P=0.024).The 1-,3-and 5-year survival rates in CCRT group were 88.2%,75.0% and 66.2% respectively,while they were 80.9%,60.3% and 50.0% respectively in radiotherapy group.The incidence rates of early radioactive rectum reaction in CCRT group and radiotherapy group were 17.6% and 13.2% respectively,and the incidence rates of bladder reaction in these two groups were 7.4% and 4.4% respectively.The metastasis rate in CCRT group was much lower than that in radiotherapy group.The bone marrow suppression and gastrointestinal reaction were more serious in CCRT group than those in radiotherapy group,but patients were usually able to tolerate the sickness after symptomatic treatment.ConclusionsThe effect of CCRT on intermediate and advanced cervical cancer is superior to radiotherapy,as it could reduce metastasis rate and enhance survival rate.

Key words: Cervical cancer, Concurrent chemoradiotherapy (CCRT), Survival, Metastasis, Adverse reactions