Abstract: Objective To explore the correlation between IGF-1R polymorphism and genetic susceptibility to hepatocellular carcinoma (HCC) in the area with high incidence of HCC in Guangxi.Methods A case-control study was conducted which included 113 HCC patients and 113 normal controls.All of the cases were from the areas with high incidence of HCC in Guangxi.The SNP locus rs 61740868 of gene IGF-1R was selected as a genetic marker，and its genotypes as well as mutation frequency were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).Results There was no mutation in SNP locus rs 61740868 of IGF-1R in both HCC cases and controls.The expressions of IGF-1R were not statistically different between the two groups (P＞0.05).Conclusion Polymorphism of IGF-1R SNP locus rs 61740868 is not associated with HCC，it may not be a risk factor for HCC.

Key words: Hepatocellular carcinoma, Insulin-like growth factor 1 receptor (IGF-1R), Single nucleotide polymorphism