Abstract: Objectives To evaluate the effect and adverse reactions of capecitabine combined with vinorelbine on treating the recurrent and metastatic breast cancer that failed to the treatment of taxanes and anthracycline. Methods Thirty-two patients with recurrent or metastatic breast cancer were treated by capecitabine and vinorelbine.Vinorelbine was given at the dose of 25mg/m² on day 1st and day 8th，and xeloda was given at the dose of 2 000mg/m²/d，twice a day for two weeks followed by one week of rest as a cycle. All patients were treated with two or more cycles.Results Among the 32 patients，five achieved complete response，12 achieved partial response. The total response rate was 53.1%，and the clinical benefit response (CR+PR+SD) was 87.5%.The common adverse reactions were hand-foot syndrome，skin pigmentation，nausea，vomiting，anorexia and fatigue.Mild moderate anemia and leukopenia were observed in 36.4% of patients. Mild elevation of total bilirubin and alanine transaminase (ALT) occurred in a few patients. Conclusion Capecitabine combined with vinorelbine is an effective ragmen for treating patients with relapsed and metastatic breast cancer，especially for those who have failed to chemotherapy with anthracycline and taxanes. The regimen is tolerable while has mild adverse reactions.

Key words: Breast cancer, Capecitabine, Vinorelbine, Chemotherapy