Abstract:

Objective  To explore the expression and possible significance of melanoma-associated antigen MAGE-D4 in human meningioma tissues. Methods Expression of MAGE-D4 was determined by RT-PCR in 36 meningiomas tissues and 8 normal brain tissues. The associations between MAGE-D4 expression and clinico-pathological features was statistically evaluated. Results Expression rates of MAGE-D4 mRNA was significantly higher in meningioma tissues（58.33% and 12.50%，respectively）than that in normal brain tissues（P<0.05）. MAGE-D4 mRNA expression wasn′t related to gender，age，tumor size and histological types（P＞0.05）. Conclusion MAGE-D4 mRNA was significantly expressed in meningioma tissues，which may serve as a target antigen for meningioma immunotherapy.

Key words: Meningioma, Melanoma-associated antigen, Immunotherapy, MAGE-D4 mRNA