Abstract: Objective To investigate the clinical feasibility and safety of a domestically produced single⁃port robotic⁃assisted laparoscopic radical cystectomy with orthotopic ileal neobladder. Methods A retrospective analysis was conducted on the clinical data of three patients who underwent this procedure  at Sun Yat⁃sen Memorial Hospital, Sun Yat⁃sen University, between June and July 2025. The cohort comprised one female and two male individuals. Relevant literature was reviewed concurrently. Results All three patients successfully completed the surgery without conversion to open surgery or alternative surgical approaches. The average total operative time was 351 minutes, with a range of 327 to 395 minutes,  and the average intraoperative blood loss was 83 mL, ranging from 20 to 200 mL. None of the patients experienced severe complications such as intestinal fistula, urinary leakage, blood transfusion, or intraoperative major hemorrhage, and all were discharged within 14 days postoperatively. Postoperative pathology confirmed negative lymph nodes and negative margins in the urethra and bilateral ureters. Conclusions The perioperative safety of domestically manufactured single⁃port robotic⁃assisted laparoscopic radical cystectomy with orthotopic ileal neobladder is controllable, demonstrating its clinical feasibility.

Key words: Bladder cancer, Single?port robot, Radical cystectomy, Orthotopic ileal neobladder