Abstract: Objective To investigate the features of contrast-enhanced ultrasound (CEUS) and ultramicrovascular imaging in breast sclerosing adenosis (SA). Methods The CEUS and ultramicrovascular imaging of 15 SA patients and 40 cases of infiltrating ductal carcinoma (IDC) patients admitted to Guangxi Medical University Cancer Hospital from December 2017 to December 2021 were analyzed retrospectively, and the CEUS and ultramicrovascular imaging features of SA were analyzed combined with pathological features. Results In the qualitative features of CEUS, there were statistically significant differences between SA and IDC in enhancement intensity, lesion edge, perfusion defects, lesion scope and ultramicrovascular imaging architecture (all P<0.05). Among quantitative parameters, there were statistically significant differences between SA and IDC in peak intensity, curve slope, area under the curve, inflow area and outflow area (all P<0.05). Conclusions The certain characteristics in CEUS and ultramicrovascular imaging of breast SA are significantly different from IDC, and a comprehensive understanding of these features helps improve the diagnostic accuracy of breast sclerosing adenosis.

Key words: Breast sclerosing adenosis, Invasive ductal carcinoma, Contrast-enhanced ultrasound, Ultramicrovascular imaging