Abstract: Recurrence and metastasis are the main causes of death in nasopharyngeal carcinoma, with poor prognosis for patients and significant individual variations, necessitating improvement in overall survival. In recent years, extensive research on the treatment of recurrent/metastatic nasopharyngeal carcinoma(R/M NPC), with notable advancements in immunotherapy, targeted therapy, and radiotherapy, providing patients more reasonable and effective treatment options. This review summarizes current progress on immunotherapy, targeted therapy, their combination, and radiotherapy for patients with R/M NPC.

Key words: Nasopharyngeal carcinoma, Recurrence, Metastasis, Immunotherapy, Targeted therapy, Radiotherapy