Abstract: Objective To inquiry the usefulness of methylene blue subcutaneous injection into areola in sentinel lymph node biopsy for breast cancer.Methods 1%methylene blue 2ml were injected into areola by 4 points before the operation on breast cancer.The lymph node were named as SLN and non-SLN according their locations related to areola.Result The detection rate of sentinel lymph node was 96.4%(54/56).The false negative rate and the false positive rate were 6.1%(2/33) and 0,respectively. Conclusion Subcutaneous injection methylene blue into areola for sentinel lymph node biopsy is helpful for evaluating the lymph node situation of breast cancer.

Key words: Sentinel lymph node, Methylene blue injection, Breast cancer