Abstract: Objective To investigate the expression of human papilloma virus 6（HPV6） and HPV11 in juvenile onset recurrent respira-tory papilloma（JORRP） and examine differences in HPV load and infection rate at initial infection and after complete cure. Methods A total of 29 children with JORRP were analyzed by real-time fluorescent quantitative PCR to determine HPV load at initial infection and after complete cure. Results ① HPV6 and HPV11 load did not differ significantly from each other at initial infection or after complete cure （P﹥0.05）.② The rate of HPV6 infection was similar at initial infection and after complete cure（P﹥0.05），while the overall rate of HPV11 infection was different （P﹤0.05）. Conclusion ① HPV6 and HPV11 load did not differ significantly from each other at initial infection or after complete cure.② Children had HPV11 virus at initial infection，and the rate of HPV11 infection declined after complete cure.

Key words: HPV6 , HPV11, JORRP, RT-PCR