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25 March 2013, Volume 5 Issue 1 Previous Issue    Next Issue

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Ability of lymphatic endothelial cell microenvironment to affect the epithelial-mesenchymal transition in ovarian carcinoma cell lines showing highly lymphatic directional metastasis LIU Li,LI Dan-rong,ZHONG Yan-ping,LI Li, GAO Ting,RUAN He-yun,GUAN Xiao 2013, 5 (1):  1-5.  doi: 10.3969/j.issn.1674-5671.2013.01.01 Abstract ( 455 )   PDF (591KB) ( 689 )   Save Objective To explore whether creating a human lymphatic endothelial cell microenvironment under culture or co-culture conditions can affect the invasion and migration activity and the epithelial-mesenchymal transition in the ovarian carcinoma SKOV3-PM4 cell line，which shows highly lymphatic directional metastasis. Methods SKOV3-PM4 cells were cultured in a lymphatic endothelial cell microenvironment either by using conditioned medium from cultures of human lens epithelium cells（HLECs） or by co-culturing with HLECs.The ability of SKOV3-PM4 cells to invade and migrate was observed using transwell chambers.Expression of transforming growth factor（TGF-β1），E-cadherin and vimentin in SKOV3-PM4 cells was analyzed by immunohistochemistry. Results The proportion of SKOV3-PM4 cultures showing invasion after incubation in HLEC-conditioned medium was（53±11）%，compared to （30±5）% for control cells；the proportion of SKOV3-PM4 cultures showing migration behavior was（48±5）%，compared to（34±2）% for control cells.Expression of TGF-β1 and vimentin was up-regulated and expression of E-cadherin down-regulated in SKOV3-PM4 cells after culturing them in HLEC-conditioned medium or co-culturing them with HLECs. Conclusions A human lymphatic endothelial cell microenvironment can alter the epithelial-mesenchymal transition in ovarian carcinoma cells and enhance their invasion and migration ability. Related Articles | Metrics

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Construction of a recombinant eukaryotic expression vector of miR-21 and its effects on proliferation and apoptosis in gastric cancer cells SUN Yang-yang，DING Jun，ZHOU Xiao-li，ZHU Yi-zhi 2013, 5 (1):  6-11.  doi: 10.3969/j.issn.1674-5671.2013.01.02 Abstract ( 681 )   PDF (648KB) ( 746 )   Save Objective To construct a recombinant expression plasmid encoding human miR-21，and explore the effects of miR-21 expression on the proliferation and apoptosis of gastric cancer cells. Methods Double-stranded DNA encoding human miR-21 was designed and used to construct eukaryotic expression plasmid pPG-miR-EGFP.The plasmid was transfected into the human gastric cancer cell line SGC-7901 using LipofectamineTM2000，and the transfection rate was monitored by fluorescence microscopy. Levels of miR-21 were analyzed by RT-PCR in three sets of cells：untransfected cells（control group），cells transfected with empty vector（empty group）， and cells transfected with expression plasmid（expression group）.In addition，cell growth and proliferation were assayed using MTT，and cell cycle progression and apoptosis were analyzed using flow cytometry based on Hoechst 33258 staining.Expression of PTEN，PCNA， PDCD4，bcl-2，and cyclin D1 were analyzed using Western blotting and immunohistochemistry. Results The recombinant expression plasmid pPG-miR-21-EGFP was successfully constructed and transfected into 75% of cells. Levels of miR-21 were significantly lower in the expression group than in the empty or control groups（t=7.12，5.78，P<0.05）.Expression of cyclin D1，PCNA，and bcl-2 was significantly lower in the expression group than in the other two groups（P<0.05），while expression of PDCD4 and PTEN was significantly higher（P<0.05）.Cells in the expression group showed lower growth and higher apoptosis rates than cells in the control group（P<0.05），and flow cytometry revealed a greater proportion of cells in G1 phase［（69.71±0.314）% vs （50.1±0.331）%］ and a smaller proportion in S phase［（14.68±0.448）% vs （28.47±0.316）%］（P<0.05 in both cases）. Conclusions Recombinant expression plasmid pPG-miR-21-EGFP can down-regulate miR-21 expression in human gastric cancer SGC-7901 cells and suppress their proliferation to some extent.It can also promote apoptosis，such that many cells stop at the G1 phase and do not proceed to S phase.These effects on growth and apoptosis may be related to down-regulation of cyclin D1，PCNA，and bcl-2 and/or with up-regulation of PDCD4 and PTEN. Related Articles | Metrics

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Molecular studies of growth inhibition by 3-bromopyruvic acid in human gastric tumors implanted in nude mice CAO Wei，ZHANG Xiao-dong，LU Yun-fei 2013, 5 (1):  12-16.  doi: 10.3969/j.issn.1674-5671.2013.01.03 Abstract ( 568 )   PDF (366KB) ( 719 )   Save Objective To investigate the effects of 3-Bromopyruvic acid（3-BrPA） on the growth of gastric cancer in vivo and to explore how it exerts these effects． Methods Human gastric carcinoma SGC-7901 cells were subcutaneously implanted in nude mice，which were randomly divided into six groups（each n=10） that received subcutaneous injections of 1.85，2.23，or 2.67 mg/kg 3-BrPA；5-FU； or PBS（two groups）.After 28 days of treatment，the expression of apoptosis-associated proteins p53，bcl-2，bax and active caspase-3 was examined by immunohistochemistry and Western blotting.Hexokinase activity was assessed using a commercial kit. Results Hexokinase activity gradually declined with increasing 3-BrPA dose. Mice in the 3-BrPA groups showed lower expression of p53 and bcl-2 and higher expression of bax and active caspase-3 than did mice in the PBS groups（P<0.05）． Conclusion 3-BrPA can induce apoptosis of human gastric cancer cells，and it appears to do so by altering expression of apoptosis-associated proteins and inhibiting hexokinase activity. Related Articles | Metrics

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Proteomic study of serum biomarkers in patients undergoing different ventilation modes LI Peng1，HUANG Bing，LI Li2，LI Yang，PANG Ling-hui，RUAN Lin，PENG Dan-hui，LIN Fei，GU Yong-hui，HUANG Yu，CHEN Xiao-dong 2013, 5 (1):  16-20.  doi: 10.3969/j.issn.1674-5671.2013.01.04 Abstract ( 542 )   PDF (321KB) ( 671 )   Save Objective To identify serum proteins differentially expressed in patients undergoing different ventilation modes during thoracic operations. Methods Ten patients underwent one-lung ventilation（group A） and 10 underwent two-lung ventilation（group B） during thoracic operations. Serum samples were collected， and highly abundant serum proteins were purified on an immunoaffinity chromatography column.The iTRAQ technique combined with two-dimensional liquid chromatography tandem mass spectrometry （2D LC-MS/MS） was used to identify and quantitate proteins differentially expressed between the two groups. Results A total of 189 pro-teins were identified by mass spectrometry，and 42 proteins were differentially up-or down-regulated by at least 20%.Of these proteins，33 were up-regulated and 9 were down-regulated in group A compared to group B. Conclusions The iTRAQ technique is effective for comparative proteomic studies.Protein expression profiling may prove a useful approach for investigating the pathogenesis of lung injury in patients undergoing one-lung ventilation. Related Articles | Metrics

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Inhibition of RSK4 gene expression in the breast cancer cell line MCF-7 using lentiviral vector-mediated shRNA interference HAN Lu-lu，LIU Jian-lun，WEI Wei 2013, 5 (1):  20-23.  doi: 10.3969/j.issn.1674-5671.2013.01.05 Abstract ( 480 )   PDF (440KB) ( 941 )   Save  Objective To design a lentiviral vector-based system for exploring the effects of silencing the ribosomal protein S6 kinase 4（RSK4） gene in the human breast cancer cell line MCF-7. Methods A lentiviral RNA interference vector targeting the RSK4 gene was designed and stably transfected into MCF-7 cells.Expression of RSK4 mRNA and protein was analyzed by real-time PCR and Western blotting. Results Stable transfection led to 98.2% inhibition of RSK4 mRNA and 80.1% inhibition of RSK4 protein. Conclusion Stable transfection of the breast cancer cell line MCF-7 using a lentiviral RNA interference vector can significantly inhibit expression of RSK4 mRNA and protein. Related Articles | Metrics

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Establishment of a radioresistant human colon cancer line SUN Ming-hui，XIAO Sheng-ying，LIU Ai-qun，GE Lian-ying 2013, 5 (1):  24-27.  doi: 10.3969/j.issn.1674-5671.2013.01.06 Abstract ( 586 )   PDF (305KB) ( 550 )   Save Objective To establish the radioresistant human colon cancer cell line SW480-R，which could serve as a reference line for mechanistic studies of radioresistance. Methods Human colon SW480 cancer cells were repeatedly exposed to X-rays（2 Gy per fraction）.After exposing the cells for different periods， the novel radioresistant subline SW480-R was obtained.The doubling time of SW480 and SW480-R cells was determined by MTT assay，and relative radiosensitivity by standard colony formation assay.Survival rates after irradiation were measured by MTT assay. The distribution of cells in different stages of the cell cycle was investigated by flow cytometry before and after irradiation. Results Carcinoma cells survived after being exposed to 2 Gy for 3 weeks， and these cells were considered to be a radioresistant subline of SW480 cells.The resistant SW480-R cells showed greater radioresistance and longer doubling time than the parental SW480 cells（33.93 vs 24.87 h，P<0.05）.The resistant cells showed a higher survival rate after irradia-tion than did SW480 cells（98.40 vs 92.81%，P<0.001），and a higher percentage of cells in G2 /M phase. Conclusion The new subline SW480-R is more radioresistant than the parental SW480 cell line， and it has a different cell cycle distribution. Related Articles | Metrics

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Impact of fresh Gecko active component on proliferation and apoptosis of human hepato-cellular carcinoma cell line BEL-7404 LU Hai-juan，LUO Xiao-ling，YUE Hui-fen，SHEN Xiao-yun，ZHANG Xue-rong，XIE Yu-an，WU Ji-ning 2013, 5 (1):  28-31.  doi: 10.3969/j.issn.1674-5671.2013.01.07 Abstract ( 488 )   PDF (394KB) ( 686 )   Save Objective To investigate the effects of fresh Gecko active component on proliferation and apoptosis in human hepatocel-lular carcinoma cell line BEL-7404. Methods Solutions were prepared containing different concentrations of freeze-dried fresh Gecko active component powder， and these were added to BEL-7404 cultures.MTT assay was used to measure the antiproliferative effects of the different concentrations，and flow cytometry was used to assess the extent of apoptosis at the different concentrations. Results Fresh Gecko active component inhibited BEL-7404 proliferation relative to the control group（P<0.05） in a time- and dose-dependent manner.The component also induced apoptosis in BEL-7404 cells，with the highest concentration（2 560 μg/ml） showing statistically significant effects（P<0.05）. Conclusion Fresh Gecko active component can efficiently inhibit cell proliferation and induce apoptosis in the human hepatocellular carcinoma cell line BEL-7404. Related Articles | Metrics

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Growth inhibition and apoptosis induction by Camellia chrysantha (Hu) Tuyama in human esophageal squamous carcinoma cells DAI Lu，LI Ji-lin，SHEN Xiao-yun，TANG Yan-ping，FENG Yan，LI Lin，ZHANG Li-tu 2013, 5 (1):  32-35.  doi: 10.3969/j.issn.1674-5671.2013.01.08 Abstract ( 450 )   PDF (393KB) ( 727 )   Save Objective To explore the ability of an aqueous extract of Camellia chrysantha（Hu） Tuyama to inhibit proliferation and induce apoptosis in human esophageal squamous cell carcinoma cells. Methods Eca109 cells were treated with aqueous extract of Camellia chrysantha（Hu） Tuyama at various concentrations，and then cell growth was assessed by trypan blue exclusion and cell morphology by transmission electron microscopy（TEM）. Results Aqueous extract of Camellia chrysantha（Hu） Tuyama inhibited Eca109 growth in a dose-and time-dependent manner.The extract also induced apoptosis-like morphological changes in the cells. Conclusion These results suggest that aqueous extract of Camellia chrysantha（Hu） Tuyama inhibits cell growth and induces apoptosis in human esophageal squamous carcinoma cells. Related Articles | Metrics

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Mutational analysis of the protein-coding sequence of the POLD1 gene in human hepato-cellular carcinoma cell line SMMC-7721 HUANG Wen-tao，WU Qiong，LI Jin-yuan，HUANG Yi，XU Heng 2013, 5 (1):  35-38.  doi: 10.3969/j.issn.1674-5671.2013.01.09 Abstract ( 479 )   PDF (340KB) ( 594 )   Save  Objective To analyze mutations in the protein-coding region of the POLD1 gene in the human hepatocarcinoma cell line SMMC-7721；this gene encodes an enzyme critical for DNA replication. Methods Total RNA was isolated from SMMC-7721 cultures，and the POLD1 gene coding region was amplified by RT-PCR，purified and A-tailed， and then cloned into a T-vector. Mutations were detected by sequencing. Results The protein-coding region of the POLD1 gene was successfully amplified and found to contain 12 mutations，11 of which were nucleotide changes and 1 was a nucleotide deletion. Conclusions SMMC-7721 en-codes a mutated POLD1 gene， and the mutations lead to changes in the protein sequence. Related Articles | Metrics

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Analysis on death from malignancies and cause eliminated life among residents in Daiyue District of Taian City AN Xing-gui，LIANG Ai-hong，LI Xin-wei，ZHANG Xian-fen，CHEN Yong 2013, 5 (1):  39-41.  doi: 10.3969/j.issn.1674-5671.2013.01.10 Abstract ( 465 )   PDF (226KB) ( 691 )   Save Related Articles | Metrics

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Correlated expression of E-cadherin and EpCAM in the gross morphology subtype of nodular hepatocellular carcinoma WANG Shi-jun，CHEN Jie，PENG Ning-fu，QI Lu-nan，XIANG Bang-de，HUANG Guo-xiong，LI Le-qun 2013, 5 (1):  42-45.  doi: 10.3969/j.issn.1674-5671.2013.01.11 Abstract ( 524 )   PDF (445KB) ( 549 )   Save Objective To correlate expression of E-cadherin and EpCAM with the survival prognosis of patients with nodular hepato-cellular carcinoma（HCC）. Methods A total of 100 patients with HCC who underwent surgery at the Affiliated Tumor Hospital of Guangxi Medical University between 2008 and 2011 were selected for this study.These patients had been diagnosed with HCC on the basis of pathology，and they had primary tumors less than 5 cm in diameter.Patients were divided into 3 groups：single nodule（SN） group（n=61），single nodular with extranodular growth（SNEG） group（n=21），and a confluent multinodular（CM） group（n=18）.Expres-sion of E-cadherin and EpCAM was assessed in each group by immunohistochemistry，and Kaplan-Meier survival analysis was per-formed. Results Mean postoperative survival was 33.51±0.89 months in the SN group， which was significantly higher than the 24.25±2.58 months in the SNEG group（P=0.000） and higher （but not significantly） than the 29.30±2.59 months in the CM group.The rate of expression of E-cadherin was 40.98%（25/61） in the SN group，9.52%（2/21） in the SNEG group，and 27.78%（5/18） in the CM group （P＜0.05）.The corresponding results for EpCAM were 22.95%（14/61），52.38%（11/21），and 27.78%（5/18）（P＜0.05）.The rates of E-cadherin and EpCAM expression differed significantly between the SN and SNEG groups（P＜0.05 in both cases）.Pearson correlation analysis showed a negative correlation in the levels of these two proteins（r=-0.580，P<0.05）. Conclusions Patients in the SNEG group may be at risk of HCC recurrence.Low expression of E-cadherin and high expression of EpCAM are associated with poor prognosis in patients with HCC.The negative correlation be tween E-cadherin and EpCAM expression suggests that these two proteins may be used together to predict prognosis of patients with HCC. Related Articles | Metrics

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Determination and clinical significance of HIF-1α，VEGF and TGF-β1 expression in nonsmall cell lung cancinoma WU Xin-tian,ZHOU Shao-zhang,MO Juan-mei,ZENG Ai-ping,YU Qi-tao,SONG Xiang-qun 2013, 5 (1):  46-49.  doi: 10.3969/j.issn.1674-5671.2013.01.12 Abstract ( 470 )   PDF (362KB) ( 723 )   Save Objective To determine the expression and clinical significance of HIF-1α，VEGF and TGF-β1 in non-small cell lung cancer（NSCLC）. Method The immunohistochemical SP method was used to analyze expression of HIF-1α，VEGF and TGF-β1 in 85 samples of NSCLC tissue and 13 samples of normal lung tissue. Results A greater proportion of NSCLC tissue than normal lung tissue was positive for HIF-1α，VEGF and TGF-β1.Expression of these proteins positively correlated with NSCLC clinical stage and lymph node metastasis（P<0.01）.However，no correlation was observed between expression of HIF-1α，VEGF and TGF-β1 and other clinico-pathological features such as age，sex，pathology type or degree of differentiation（P>0.05）.Levels of HIF-1α，VEGF and TGF-β1 correlated positively with one another in NSCLC tissue（P<0.05）. Conclusion Elevated expression of HIF-1α，VEGF and TGF-β1 may be associated with tumor invasion and metastasis in NSCLC. Related Articles | Metrics

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Analysis of potential associations of hepatitis B virus infection and family history of hepatocellular carcinoma with age at liver cancer diagnosis in Guigang city LIU Yi1,XIAO Jun,MO Xian-wei,HE Ke,XU Yuan-bing,LIU Chang-hua,CHEN Jian-si,LUO Han-chuan,LIN Yuan 2013, 5 (1):  50-53.  doi: 10.3969/j.issn.1674-5671.2013.01.13 Abstract ( 488 )   PDF (294KB) ( 1032 )   Save Objective To explore potential associations of HBV infection and family history of hepatocellular carcinoma（HCC） with age at HCC diagnosis. Methods A total of 1 365 new patients with HCC treated between 2004 and 2008 at the People′s Hospital of Guigang were included in a cross-sectional study，and data were analyzed retrospectively using Excel. Results Patients with a family history of HCC presented the disease at a signif-icantly earlier age than did those with no family history（P＜0.05）.Age at diagnosis did not differ significantly between patients who were HBsAg-negative and patients who were HBsAg-positive（P=0.738）.Among patients with no family history of HCC，age at HCC diagnosis did not differ significantly between those who were HBsAg-positive and those who were HBsAg-negative（P=0.443）. However，age at HCC diagnosis of patients with a family history of the disease，regardless of their HBsAg status，was significantly lower than that of HBsAg-negative patients with no family history（P＜0.05）. Conclusion Among patients with HCC in Guigang City，those with a family history of the disease are diagnosed at an earlier age than are those with no family history，regardless of their HBsAg status. Related Articles | Metrics

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Survey of computed tomography imaging characteristics of 646 pulmonary nodules or lung masses in Qingdao XU Feng,XU De-xiang,LIN Xiao-yan 2013, 5 (1):  53-57.  doi: 10.3969/j.issn.1674-5671.2013.01.14 Abstract ( 589 )   PDF (335KB) ( 633 )   Save Objective To describe the etiology and computed tomography（CT） characteristics of pulmonary nodules and lung masses in order to provide a basis for differentiating benign and malignant masses. Methods CT chest scans were performed on 646 patients from five research centers in Qingdao；patients had been diagnosed with benign or malignant masses based on pathology.Scans for the two types of masses were compared using statistical analysis. Results CT scans for benign and malignant masses differed significantly in sentus，pleural indentation and air bronchogram results. Conclusion Spiculation and pleural indentation on CT scans suggest that the lung mass or pulmonary nodule may be malignant，while air bronchogram suggests it may be benign. Related Articles | Metrics

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Expression of HPV6/HPV11 in juvenile onset recurrent respiratory papillomatosis TANG Zhao-xian,WU Sen-yong,HUANG Shi-ping,WEN wen-sheng 2013, 5 (1):  58-61.  doi: 10.3969/j.issn.1674-5671.2013.01.15 Abstract ( 490 )   PDF (370KB) ( 554 )   Save Objective To investigate the expression of human papilloma virus 6（HPV6） and HPV11 in juvenile onset recurrent respira-tory papilloma（JORRP） and examine differences in HPV load and infection rate at initial infection and after complete cure. Methods A total of 29 children with JORRP were analyzed by real-time fluorescent quantitative PCR to determine HPV load at initial infection and after complete cure. Results ① HPV6 and HPV11 load did not differ significantly from each other at initial infection or after complete cure （P﹥0.05）.② The rate of HPV6 infection was similar at initial infection and after complete cure（P﹥0.05），while the overall rate of HPV11 infection was different （P﹤0.05）. Conclusion ① HPV6 and HPV11 load did not differ significantly from each other at initial infection or after complete cure.② Children had HPV11 virus at initial infection，and the rate of HPV11 infection declined after complete cure. Related Articles | Metrics

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Clinical outcomes of multiple organ resection to treat locally advanced gastric cancer： analysis of 93 cases ZUO Chao-hui,ZHANG Li,OU YANG Yong-zhong,TANG Ming, LIN Jin-guan, XIAO Hua, QIU Xiao-xin, PAN shu-guang,YIN bin, LUO Wei, LI Jun-jun, ZHU Hai-zhen 2013, 5 (1):  61-64.  doi: 10.3969/j.issn.1674-5671.2013.01.16 Abstract ( 475 )   PDF (322KB) ( 732 )   Save Objective To investigate clinical outcomes and prognosis for patients undergoing multiple organ resection to treat locally advanced gastric cancer. Methods We retrospectively analyzed 93 patients with locally advanced gastric cancer who underwent multi-ple organ resection in our hospital between January 2002 and December 2009. Results Of the 93 patients，24 underwent distal pan-createctomy and splenectomy；17，splenectomy；10，transverse colectomy；10，left hepatectomy；7，cholecystectomy；5，diaphragmatic re-section；5，splenectomy；5，distal pancreatectomy plus transverse colectomy；5，double oopherectomy；4，left hepatectomy plus transverse colectomy；3，pancreatoduodenectomy；2，auxiliary adrenalectomy；and 1，distal pancreatectomy，splenectomy，left hepatectomy，diaphrag-matic resection and auxiliary adrenalectomy.The overall preoperative neoadjuvant chemotherapy rate was 25/93（26.88%），and tumor release grades were distributed as follows：grade 0，4 patients； grade 1，6 patients； grade 2，8 patients；grade 3，5 patients；and grade 4，2 patients.Postoperative morbidity and mortality rates were，respectively，29/93（31.18%）and 4/93（4.30%）.The 1- and 3-year overall survival rates were 50.11% and 26.12%， respectively. Conclusions Multiple organ resection is an effective treatment for locally ad-vanced gastric cancer and it improves survival rates. Preoperative neoadjuvant chemotherapy improves survival and resection rates. Related Articles | Metrics

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Clinical observation on 3DCRT combined with compound Salvia injection or DDP for treating esophageal cancer YOU Sheng-yong,PENG Kang-ming,ZHOU Jiang-yun 2013, 5 (1):  65-67.  doi: 10.3969/j.issn.1674-5671.2013.01.17 Abstract ( 493 )   PDF (263KB) ( 940 )   Save Related Articles | Metrics

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The application of problem-based teaching method in gynecological oncology teaching practice SONG Hong-lin 2013, 5 (1):  68-70.  doi: 10.3969/j.issn.1674-5671.2013.01.18 Abstract ( 411 )   PDF (275KB) ( 690 )   Save Related Articles | Metrics

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Cdc25A and neoplasms LU Xiao-xu,SUN Wen,CAO Ji 2013, 5 (1):  70-72.  doi: 10.3969/j.issn.1674-5671.2013.01.19 Abstract ( 466 )   PDF (263KB) ( 959 )   Save Related Articles | Metrics

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Progress in carcinoembryonic antigen monitoring in metastatic colorectal caner XU Yuan-bing,LIN Yuan 2013, 5 (1):  73-75.  doi: 10.3969/j.issn.1674-5671.2013.01.20 Abstract ( 476 )   PDF (260KB) ( 840 )   Save Related Articles | Metrics

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Squamous cell carcinoma antigen and malignant neoplasms LAO Ming,ZHU Bo 2013, 5 (1):  76-79.  doi: 10.3969/j.issn.1674-5671.2013.01.21 Abstract ( 586 )   PDF (272KB) ( 646 )   Save Related Articles | Metrics

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Research progress of primary liver cancer TANG Yun-tian,TANG Bu-jian 2013, 5 (1):  79-82.  doi: 10.3969/j.issn.1674-5671.2013.01.22 Abstract ( 559 )   PDF (311KB) ( 1112 )   Save Related Articles | Metrics

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Research progress of prevention and treatment in acute skin injury induced by irradiation LI Rong-qing,JIANG Dai-qi 2013, 5 (1):  83-85.  doi: 10.3969/j.issn.1674-5671.2013.01.23 Abstract ( 533 )   PDF (299KB) ( 734 )   Save Related Articles | Metrics

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Protein secretion is required for pregnancy-associated plasma protein-A to promote lung cancer growth in vivo PAN Hong 2013, 5 (1):  85-86.  doi: 10.3969/j.issn.1674-5671.2013.01.24 Abstract ( 466 )   PDF (250KB) ( 533 )   Save Related Articles | Metrics