Abstract: Objective To explore potential associations of HBV infection and family history of hepatocellular carcinoma（HCC） with age at HCC diagnosis. Methods A total of 1 365 new patients with HCC treated between 2004 and 2008 at the People′s Hospital of Guigang were included in a cross-sectional study，and data were analyzed retrospectively using Excel. Results Patients with a family history of HCC presented the disease at a signif-icantly earlier age than did those with no family history（P＜0.05）.Age at diagnosis did not differ significantly between patients who were HBsAg-negative and patients who were HBsAg-positive（P=0.738）.Among patients with no family history of HCC，age at HCC diagnosis did not differ significantly between those who were HBsAg-positive and those who were HBsAg-negative（P=0.443）. However，age at HCC diagnosis of patients with a family history of the disease，regardless of their HBsAg status，was significantly lower than that of HBsAg-negative patients with no family history（P＜0.05）. Conclusion Among patients with HCC in Guigang City，those with a family history of the disease are diagnosed at an earlier age than are those with no family history，regardless of their HBsAg status.

Key words: Liver neoplasms, Hepatocellular carcinoma, Family history of HCC, HBV infection, Clinical epidemiology