Abstract: Objective To investigate the expression and prognostic usefulness of ERCC1，BAG-1 and BRCA1 in patients with non-small cell lung cancer（NSCLC） treated with platinum-based adjuvant chemotherapy. Methods RT-PCR was used to investigate the mRNA expression of ERCC1，BAG-1 and BRCA1 in 85 samples of NSCLC tissues and 34 tumor-adjacent tissues.Relationships of the expression of these three genes with overall survival（OS） were analyzed. Results ①OS was significantly longer in patients negative for ERCC1 or BAG-1 mRNA expression than in those positive for expression of either gene（P=0.001）.Platinum-based chemotherapy was more effective for patients negative for ERCC1 or BAG-1 than for the corresponding positive patients（P=0.001 and P=0.002）， respectively.②OS may be longer in patients negative for BRCA1 mRNA expression than in BRCA1-positive patients （P=0.052）. ③Multivariate analysis suggests that ERCC1 and BAG-1 may be prognostic indicators for patients receiving platinum-based adjuvant chemotherapy（P=0.027 and P=0.022）. Conclusion Expression of ERCC1 and BAG-1 mRNA may be useful in the prognosis of NSCLC treated with platinum.

Key words: Lung neoplasm, Non-small cell lung cancer, ERCC1, BAG-1, BRCA1, Chemotherapy, Prognosis