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25 March 2014, Volume 6 Issue 1 Previous Issue    Next Issue

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Mitophagy of nasopharyngeal carcinoma CNE-1 cells induced by acetylated emodin derivative MO Yuan-yuan,HOU Hua-xin,LI Dan-rong,CHEN Yun-long,LIANG Yan,MO Chun-yan,WANG Chun-miao,LI Jing 2014, 6 (1):  1-6.  doi: 10.3969/j.issn.1674-5671.2014.01.01 Abstract ( 426 )   PDF (692KB) ( 635 )   Save Objective To explore the relationship between mitochondrial damage and mitophagy in nasopharyngeal carcinoma CNE-1 cells treated with acetylated emodin derivative. Methods CNE-1 cells were divided into a control group and groups treated with 5 or 10 mg·L-1 of acetylated emodin derivative.After treatment， autophagosome ultrastructure was analyzed by transmission electron microscopy，while mitochondrial membrane potential and levels of intracellular free calcium ion and reactive oxygen species were measured by confocal microscopy. Results Cells treated with acetylated emodin derivative showed mitochondrial damage and the presence of mitophagosomes，which were not observed in control cells.The emodin derivative also led to a significant decrease in mitochondrial membrane potential and increases in levels of intracellular free calcium ion and reactive oxygen species（P<0.05）；these effects were dose-dependent. Analyzing mitochondrial and lysosome markers of treated cells revealed typical mitophagic features， including acidic lysosomal proliferation and lysosomes containing mitochondrial remnants labeled with Mito Tracker Green. The abundance of these features was also dose-dependent. Conclusion The acetylated emodin derivative can cause mitochondrial damage in nasopharyngeal carcinoma CNE-1 cells，perhaps through a mechanism closely related to mitophagy. Related Articles | Metrics

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Expression and significance of Axin-1 during chemical induction of liver cancer in C57BL/6J mice KONG Na,KUANG Zhi-peng,YANG Fan,LI Yun-qiu,WU Ji-ning 2014, 6 (1):  7-11.  doi: 10.3969/j.issn.1674-5671.2014.01.02 Abstract ( 389 )   PDF (656KB) ( 557 )   Save Objective To analyze the expression of Axin-1 during chemical induction of liver cancer in C57BL/6J mice. Methods C57BL/6J mice were divided randomly into an experimental group（n=50）and a control group（n=45）.Mice in the experimental group were treated with diethylnitrosamine（DEN），carbon tetrachloride（CCl4） and ethanol for 20 weeks to induce hepatocellular carcinoma （HCC）.Every 2 weeks，5 mice in each group were sacrificed and liver samples were taken.Dynamic expression of Axin-1 was analyzed using real-time PCR，Western blotting and immunohistochemistry，while pathological changes were analyzed using hematoxylin staining. Results The 20-week DEN/CCl4/ethanol treatment successfully induced liver cancer in C57BL/6J mice.Based on real-time PCR and Western blotting，expression of Axin-1 mRNA and protein was significantly lower in the experimental group than in the control group between weeks 16 and 20.This expression decreased gradually over time in the experimental group：levels of mRNA were 0.421±0.083 at week 16，0.278±0.042 at week 18 and 0.120±0.028 at week 20（P＜0.05）.Immunohistochemistry showed detectable levels of Axin-1 staining in the control group at all time points tested；in the experimental group，however，the level of staining began to decrease at week 16 and was nearly undetectable at week 20. Conclusion The Wnt/β-catenin signaling pathway may be associated with HCC development，with Axin-1 acting to inhibit HCC progression. Related Articles | Metrics

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Biological Characteristics of CD90+ Cells in Human Hepatocellular Carcinoma Cell Lines XU Sa,NING Shu-fang,LI Ji-lin,FENG Yan,TANG Yan-ping,LUO Cheng-piao,ZHANG Li-tu 2014, 6 (1):  12-16.  doi: 10.3969/j.issn.1674-5671.2014.01.03 Abstract ( 522 )   PDF (473KB) ( 697 )   Save Objective To isolate CD90+ （Thy-1+） cells from human hepatocellular carcinoma （HCC） cell lines and to study their stem cell properties. Methods Fluorescence-activated cell sorting was used to detect CD90 expression in five HCC cell lines：HepG2，SMMC-7721，Bel-7404，Bel-7403 and SK-Hep-1.The tablet clone formation test was used to measure the colony-forming ability of the sorted CD90+ cells，and the CCK-8 assay was used to analyze their proliferation ability and their sensitivity to cisplatin. Results CD90 expression was detected in 66.02% of Sk-Hep-1 cells.The pelletizing rate of these CD90+ cells was（18.6±2.95）% in the tablet colony formation assay， significantly higher than that of CD90- and unsorted cells（P＜0.05）. Proliferation after 4 days in culture was significantly greater for CD90+ cells than for CD90- and unsorted cells.Cisplatin inhibited growth of CD90+ cells by 14.8%，significantly less than it inhibited the growth of CD90- cells （29.7%，P＜0.05） and unsorted cells （24.0%，P＜0.05）. Conclusion CD90+ cells are a subpopulation with tumor stem cell properties.CD90 may be a candidate biomarker for HCC stem cells. Related Articles | Metrics

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Asialoglycoprotein receptor 2 gene expression and significance in  hepatocellular carcinoma ZHANG Yu,HUANG Tian-ren,CHEN Ling,HE Guo-zhen,DENG Wei,ZHANG Chun-yan 2014, 6 (1):  16-19.  doi: 10.3969/j.issn.1674-5671.2014.01.04 Abstract ( 493 )   PDF (305KB) ( 851 )   Save Objective To explore the expression and possible significance of asialoglycoprotein receptor 2（ASGR2） gene in hepato-cellular carcinoma（HCC）. Methods Expression of the ASGR2 gene in peripheral blood was detected by RT-PCR in 55 patients with hepatocellular carcinoma，55 patients with non-HCC tumors，and 33 non-tumor control patients. Results Expression of the ASGR2 gene was detected in significantly more HCC patients （85.5%） than in non-HCC patients （65.5%，P<0.05）；in fact， the rate of positive expression was similar among HCC patients as in non-cancer controls（78.8%，P＞0.05）.Gene expression differed significantly across all three patient groups（P<0.05）.ASGR2 gene expression was not significantly associated with clinicopathological features of HCC，age， AFP，cirrhosis， or cancer family history（P＞0.05）. Conclusion ASGR2 gene expression may be associated with HCC development， and detecting expression may serve as an early predictor of pathogenesis. Related Articles | Metrics

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Expression and clinical significance of TM4SF1 protein in epithelial ovarian cancer LIU Hui-min,FENG Yan-ying,GAO Cai-yun,YANG Zhi-jun 2014, 6 (1):  20-24.  doi: 10.3969/j.issn.1674-5671.2014.01.05 Abstract ( 444 )   PDF (449KB) ( 588 )   Save Objective To investigate the expression of transmembrane 4 super family 1（TM4SF1） protein in human ovarian tissues and its relationship with clinicopathological factors. Methods The SP immunohistochemical method was used to analyze the expression of TM4SF1 protein in 16 normal ovarian epithelial tissues， 23 benign ovarian tumor tissues and 55 epithelial ovarian cancer （EOC） tissues.Relationships of TM4SF1 expression with clinicopathological features of EOC and patient prognosis were analyzed. Result ①EOC tissues showed a significantly higher rate of TM4SF1 protein expression（90.90%）than did benign ovarian tumor tissues（65.22%）or normal ovarian epithelial tissues（25.00%，P<0.05）.②The TM4SF1 protein showed markedly different localizations in various tissue types. In normal ovarian epithelial tissues，the protein localized primarily to the membranes and the basal surface of epithelial cells as well as cytoplasts; in benign ovarian tumors， the protein was observed mainly on the basal surface and in certain parts of tumor cell membranes；in EOC tissues，TM4SF1 showed a mainly cytoplasmic staining.③ Rate of TM4SF1 protein expression was significantly higher in tissues of patients with stage Ⅲ-Ⅳ EOC than in patients with stage Ⅰ-Ⅱ disease（P<0.05）.The rate of TM4SF1 protein expression was also significantly higher in tissues showing low-to intermediate tumor differentiation than in well-differentiated carcinoma tissues（P<0.05）.④ Rate of TM4SF1 protein expression showed no significant association with histological type or amount of ascites （P>0.05），but association with FIGO stage and histological grade（P＜0.05）.⑤ Cox multivariate analysis showed that positive expression of TM4SF1 protein was not an independent prognostic factor. Conclusion TM4SF1 protein is overexpressed in EOC tissue，so it may be associated with the disease. Related Articles | Metrics

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Expression and prognostic significance of ERCC1 BAG-1 and BRCA1 mRNA in non-small cell lung cancer YANG Nuo,MA Hui,XIAN Lei,CHEN Ming-wu 2014, 6 (1):  25-29.  doi: 10.3969/j.issn.1674-5671.2014.01.06 Abstract ( 385 )   PDF (451KB) ( 653 )   Save Objective To investigate the expression and prognostic usefulness of ERCC1，BAG-1 and BRCA1 in patients with non-small cell lung cancer（NSCLC） treated with platinum-based adjuvant chemotherapy. Methods RT-PCR was used to investigate the mRNA expression of ERCC1，BAG-1 and BRCA1 in 85 samples of NSCLC tissues and 34 tumor-adjacent tissues.Relationships of the expression of these three genes with overall survival（OS） were analyzed. Results ①OS was significantly longer in patients negative for ERCC1 or BAG-1 mRNA expression than in those positive for expression of either gene（P=0.001）.Platinum-based chemotherapy was more effective for patients negative for ERCC1 or BAG-1 than for the corresponding positive patients（P=0.001 and P=0.002）， respectively.②OS may be longer in patients negative for BRCA1 mRNA expression than in BRCA1-positive patients （P=0.052）. ③Multivariate analysis suggests that ERCC1 and BAG-1 may be prognostic indicators for patients receiving platinum-based adjuvant chemotherapy（P=0.027 and P=0.022）. Conclusion Expression of ERCC1 and BAG-1 mRNA may be useful in the prognosis of NSCLC treated with platinum. Related Articles | Metrics

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64 layers spiral computed tomography for the diagnosis of extrahepatic feeding arteries in hepatocellular carcinoma ZHAO Yang,SU Dan-ke,LAI Shao-lu,ZHU Xu-na,JIN Guan-qiao,LIU Li-dong,LUO Ning-bin 2014, 6 (1):  30-34.  doi: 10.3969/j.issn.1674-5671.2014.01.07 Abstract ( 399 )   PDF (504KB) ( 479 )   Save Objective To investigate factors at initial presentation of hepatocellular carcinoma（HCC） that are associated with the presence of extrahepatic collateral arteries（ExCAs）. Methods A consecutive sample of 121 patients newly diagnosed with HCC based on pathology were prospectively enrolled.Thin-section computed tomography（CT） findings were compared with surgical and pathological findings.Several features were analyzed for their potential relationship with the presence of ExCAs，including tumor size， surface location，pseudocapsule，and histopathological grade of ExCA blood supply to HCC. Results Pathology analysis identified 24 of 121 patients （19.8%） with 28 ExCAs supplying tumors; CT identified 27  patients with 30 ExCAs. CT showed high sensitivity （96.0%），specificity （96.9%） and accuracy （96.7%） for detecting ExCAs.Multiple logistic regression identified tumor size and surface location as significantly associated with the presence of ExCAs（P<0.05），while histopathological grade and the presence of pseudocapsule were not（P>0.05）. Conclusion CT reconstruction techniques can accurately reveal ExCAs in HCC patients. Certain CT findings（tumor size， surface location）are significant predictors of the presence of ExCAs. Related Articles | Metrics

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Correlation of methylenetetrahydrofolate reductase（MTHFR） C677T polymorphism and chemotherapy efficacy in lung adenocarcinoma DONG Cui-mei,KANG Ma-fei, ZHAO Yan-yi,LI Jing,TAO Li-ying 2014, 6 (1):  35-38.  doi: 10.3969/j.issn.1674-5671.2014.01.08 Abstract ( 454 )   PDF (315KB) ( 647 )   Save Objective To investigate a possible correlation between C677T polymorphism in the methylenetetrahydrofolate reductase （MTHFR） gene and chemotherapy efficacy in patients with pulmonary adenocarcinoma. Methods Peripheral blood samples from 92 patients with pulmonary adenocarcinoma were collected before chemotherapy，and the C677T polymorphism was genotyped using polymerase chain reaction-restriction fragment length polymorphism（PCR-RFLP）.We examined whether genotype correlated with whether the patients showed partial response（PR）， stable disease（SD） or progressive disease（PD） following chemotherapy. Results Of the 92 patients，56 （60.9%） had wild-type genotype （CC），13（14.1%） were homozygous mutant（TT），and 23（25.0%） were heterozygous mutant （CT）.Among the patients treated with pemetrexed/carpoplatin as first-line regimen，CC patients showed an overall response rate（ORR）of 35.7%， with 20 CC patients achieving PR；19，SD；and 17，PD.Among TT patients，ORR was 15.4%，with 2 patients achieving PR；7，SD； and 4，PD.Among CT patients，ORR was 0，with 13 achieving SD and 10，PD.ORR was significantly higher in CC patients than in TT or CT patients（P=0.001）.In addition，CC patients showed significantly longer time to progression（6.2 months） than did TT or CT patients（4.7 months；P=0.023）.Among the patients treated with gemcitabine/nedaplatin or docetaxel/nedaplatin as second-line regimen，2 CC patients showed PR；5，SD；and 10，PD.3 TT patients achieved SD；among CT patients， 1 achieved PR，2 SD and 7，PD.ORR was similar between CC and TT/CT patients（P=1.000）. Conclusions Pemetrexed in combination with carboplatin may be associated with greater therapeutic efficacy and longer time to progression in CC patients than in TT/CT patients.However， genotype at the MTHFR C677T polymorphism does not appear to influence the therapeutic efficacy of gemcitabine/nedaplatin or docetaxel/nedaplatin. Related Articles | Metrics

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Clinical significance of serum tumor marker levels（CEA，CA125，CA153） for assessing the efficacy of chemotherapy in patients with metastatic breast cancer without measurable disease IN Liu-xiao,LIANG Rong,CHEN Xin-yu,LIAO Xiao-li,LIAO Si-na,YUAN Chun-ling,LI Qian,LI Yong-qiang,WEI Ming-jing,LAN Xiao-ling,ZHU Li-jun,LIU Zhi-hui 2014, 6 (1):  39-42.  doi: 10.3969/j.issn.1674-5671.2014.01.09 Abstract ( 466 )   PDF (327KB) ( 649 )   Save Objective To study the usefulness of changes in serum levels of the tumor markers CEA，CA125，and CA153 for assessing the efficacy of chemotherapy in patients with metastatic breast cancer without measurable disease. Methods Electronic medical records were retrospectively reviewed for 81 patients with metastatic breast cancer but without measurable disease treated between January 2008 and June 2013.Serum levels of CEA，CA125， and CA153 were measured with electrochemiluminescence before and after chemotherapy，and the levels were correlated with survival. Results Patients were grouped according to whether they presented normal levels of all three serum markers before chemotherapy （negative group，n=44） or they presented elevated levels of at least one marker before chemotherapy（positive group，n=37）.Median progression-free survival （PFS） was significantly longer in the negative group （19 months） than in the positive group（9.8 months，P=0.007）.The positive and negative groups had similar overall survival （51.9 vs 37.7 months，P=0.06）.Median PFS in patients in whom at least one tumor marker declined by one degree during chemotherapy（10.2 months）was longer than that in patients in whom at least one marker declined by two degrees（5.2 months，P=0.008）.Conclusions  Elevated levels of serum CEA，CA125 or CA153 correlate with shorter PFS in metastatic breast cancer patients without measurable disease.A decline of two or more degrees in the levels of any one of these tumor markers is a significant predictor of PFS benefit. Related Articles | Metrics

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Ku70，telomerase and hTERT as novel predictors of sensitivity to neoadjuvant chemoradiotherapy to treat rectal cancer TANG Fan,QIN Yu-zhou,LIN Yuan,RU Hai-ming,XIE Xue-cheng 2014, 6 (1):  43-47.  doi: 10.3969/j.issn.1674-5671.2014.01.10 Abstract ( 332 )   PDF (494KB) ( 456 )   Save Objective To correlate the efficacy of neo-adjuvant chemoradiotherapy in phase Ⅱ and Ⅲ rectal cancer patients with expression of Ku70，telomerase and hTERT proteins. Methods Expression levels of Ku70，telomerase and hTERT were analyzed by immunohistochemistry in rectal cancer patients who responded effectively to neoadjuvant chemoradiotherapy（XELOX regimen，n=27） and in patients in whom such therapy was ineffective（n=18）.Levels in the two groups were compared before and after neoadjuvant chemoradiotherapy. Results Expression of hTERT was significantly lower in patients who responded effectively to therapy than in those who did not（P<0.05）.The two patient groups showed similar expression of Ku70 and telomerase（P>0.05）.In each of the patient groups， expression levels of hTERT， telomerase and Ku70 differed significantly before and after chemoradiotherapy （P<0.05）.Efficacy of neoadjuvant chemoradiotherapy did not correlate with sex， age， pathological type or KPS score（P>0.05）. Conclusion Expression of hTERT in phase Ⅱ and Ⅲ rectal cancer patients may correlate with the efficacy of neoadjuvant chemotherapy combined with radiotherapy. Related Articles | Metrics

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Clinical observation of locally advanced nasopharyngeal carcinoma treated by three-dimensional conformal radiation therapy（3DCRT）/intensity-modulated radiation therapy （IMRT） and synchronous cisplatin chemotherapy combined with Nimotuzumab WU Jin-tong,PENG Jun-ying,WU Chen-bing,SHEN Fen 2014, 6 (1):  47-51.  doi: 10.3969/j.issn.1674-5671.2014.01.11 Abstract ( 532 )   PDF (342KB) ( 1446 )   Save Objective To investigate the clinical efficacy，tolerability and safety of  three-dimensional conformal radiation therapy （3DCRT）/intensity-modulated radiation therapy（IMRT）and synchronous cisplatin chemotherapy combined with nimotuzumab for previously untreated，locally advanced nasopharyngeal carcinoma. Methods 40 patients with untreated，locally advanced nasopha-ryngeal carcinoma were enrolled.All patients received 3DCRT/IMRT and synchronous cisplatin chemotherapy combined with nimo-tuzumab.Planned IMRT doses in the target region were 69.96-73.92 Gy for PGTVnx，69.96-73.92 Gy for PGTVnd，60-66 Gy for PTV-1 and 54-56 Gy for PTV-2 in 33 fractions.Cisplatin（80 mg/m2 on the first day of each cycle，once every 3 weeks for a total of  2 cycles）was given concurrently with Nimotuzumab（100 mg on day 1 of radiotherapy，then once a week for a total of 8 times）. Clinical efficacy，tolerability and safety were analyzed during follow-up. Results All 40 patients completed the treatment as planned，and all patients were followed up at least 24 months. Only one patient suffered local recurrence during follow-up.At 6 months after treatment，response rate（RR） in terms of both primary lesions and positive lymph nodes was 97.5%. Acute side effects during treatment included 9 cases of grade 3 bone marrow suppression and 8 cases of grade 3 oral mucositis.No grade 4 toxicity occurred. Conclusion 3DCRT/IMRT and synchronous cisplatin chemotherapy combined with nimotuzumab showed good clinical efficacy，tolerability and safety，suggesting that the teatment can be recommended. Related Articles | Metrics

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Prognostic value of changes in hemoglobin concentration during treatment for local control of nasopharyngeal carcinoma QIU Dong-ni,WANG Lei,YANG Jiang-bo,XU Shi-min 2014, 6 (1):  51-56.  doi: 10.3969/j.issn.1674-5671.2014.01.12 Abstract ( 470 )   PDF (382KB) ( 785 )   Save Objective To examine whether changes in hemoglobin concentration during treatment local control therapy of nasopha-ryngeal carcinoma（NPC）can predict outcomes. Methods A total of 443 patients with NPC were classified into two groups：one group experienced an increase in hemoglobin concentration during radiotherapy（n=51）or a combination of radiotherapy and chemotherapy （n=90）；the other group experienced a decrease in hemoglobin after radiotherapy（n=110）or a combination of radiotherapy and chemotherapy （n=192）.Relationships between hemoglobin concentration changes and survival outcomes were analyzed. Results The group experiencing an increase in hemoglobin presented significantly greater rates of 5-year local relapse-free survival（53.5% vs 37.5%，P=0.013），5-year distant metastasis-free survival （58.5% vs 37.4%，P=0.009） and 5-year overall survival （43.3% vs 27.7%，P=0.003）.Multivariate analysis identified  age>60 years，patients with Anemia before and during treatmen，T staging and changes in hemoglobin concentration during treatment as independent prognostic factors for failure of local control therapy. Conclusion An increase in hemoglobin concentration during treatment is a prognostic factor for local control of NPC. Related Articles | Metrics

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Influence of intensity-modulated radiotherapy for nasopharyngeal carcinoma on cognitive function MO Yan-lin,QIN Ling,LI Ling,ZHU Xiao-dong,WEI Zhou-ji,YIN Xue 2014, 6 (1):  56-59.  doi: 10.3969/j.issn.1674-5671.2014.01.13 Abstract ( 428 )   PDF (298KB) ( 731 )   Save  Objective To explore the influence of intensity-modulated radiotherapy（IMRT） on cognitive function in patients with nasopharyngeal carcinoma（NPC）. Methods Between December 2012 and May 2013， patients with pathologically diagnosed NPC scheduled to receive IMRT were included.Dose-volume histograms of the temporal lobes were obtained for every patient， and the Das Naglieri Cognitive Assessment System（DN-CAS） was used to assess cognitive function before and after radiotherapy.Differences in cognitive function between patients were analyzed using the paired t-test. Results Mean radiation dose was（17.5±7.3）Gy to the left temporal lobe and（18.2±6.8）Gy to the right temporal lobe. Standardized scores on all DN-CAS subtests（Planning， Attention， Simultaneous， and Successive cognitive processes） were similar before and after radiotherapy（P＞0.05）. Conclusions IMRT did not induce any acute changes in cognitive function of NPC patients. Future studies with longer follow-up should further evaluate the poten-tial effects of radiotherapy on the cognitive function of NPC patients. Related Articles | Metrics

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Clinical observation of DP therapy combined with intrapleural injection of bleomycin in treating malignant pleural effusion by advanced non-small cell lung cancer LAI Xiao-gang,WANG Xian-dong,LIU Da-zhi,ZHOU En-tao 2014, 6 (1):  60-62.  doi: 10.3969/j.issn.1674-5671.2014.01.14 Abstract ( 402 )   PDF (292KB) ( 751 )   Save Related Articles | Metrics

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Clinical value of multi-slice CT in the diagnosis of cystadenocarcinoma in the hepatic biliary duct TANG Yi-bing，MU Jian，YI Hua 2014, 6 (1):  62-64.  doi: 10.3969/j.issn.1674-5671.2014.01.15 Abstract ( 370 )   PDF (286KB) ( 706 )   Save Related Articles | Metrics

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Diagnosis and treatment of breast phyllode tumor LIU Zhan-cong,WANG Li-ping,LI He-peng 2014, 6 (1):  64-66.  doi: 10.3969/j.issn.1674-5671.2014.01.16 Abstract ( 461 )   PDF (277KB) ( 1446 )   Save Related Articles | Metrics

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Experience of pancreaticoduodenectomy in elderly patients above 80 years WANG Zai-guo,HE Run-pei,YE Zhen-wei,LIN Zhi-qiang,HU Xia-rong,LAI Guo-wei,CHEN Liu-zhen,DENG Run-shu,LIANG Zi-jun,YU Wu-sheng,ZHENG Jing-lei,HUANG Shi-chuan,CHEN Jian-huaCHEN Liu-zhen 2014, 6 (1):  67-69.  doi: 10.3969/j.issn.1674-5671.2014.01.17 Abstract ( 376 )   PDF (314KB) ( 603 )   Save Related Articles | Metrics

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Clinical study of thalidomide to improve quality of life of geriatric tumor patients on chemotherapy JIANG Wei,ZHANG Zhang,QI Zhi-feng,WU Yue-fei,QIN Ling,LIU Peng-ying,SUN Ling-ling,WANG Yi-sheng 2014, 6 (1):  70-73.  doi: 10.3969/j.issn.1674-5671.2014.01.18 Abstract ( 399 )   PDF (290KB) ( 849 )   Save Objective To observe the effect of thalidomide on the quality of life of geriatric tumor patients undergoing chemotherapy. Methods Geriatric tumor patients on chemotherapy were divided into two groups， with one receiving thalidomide（n=34）and the other receiving only chemotherapy（n=34）.The thalidomide dose was initially 100 mg/day before sleep，which was increased weekly by 50 mg to a final dose of 200 mg/day as long as the patients tolerated the side effects.If not，the original dose was maintained.The two groups were compared in terms of Kamofsky score，QOL score，sleep status，and diet status. Results The Kamofsky and QOL scores improved to a significantly greater extent in the thalidomide group than in the control group（P<0.05）.The thalidomide group showed a 58.8% improvement in sleep status and a 55.9% improvement in diet status， both of which were significantly greater than the corresponding improvements in the control group （both 29.4%，P<0.05）.Major adverse reactions were similar in both groups（P>0.05） and included marrow depression，nausea and vomiting，and constipation． Conclusion  Thalidomide can improve the quality of life in geriatric tumor patients on chemotherapy． Related Articles | Metrics

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Effects of intraoperative and postoperative hypothermia on recovery in patients with large hepatocellular carcinoma undergoing hepatectomy LI Xiang,MO Xin-shao,CHEN Si-xia,YANG Yi-lan 2014, 6 (1):  74-77.  doi: 10.3969/j.issn.1674-5671.2014.01.19 Abstract ( 471 )   PDF (300KB) ( 580 )   Save Objective To investigate the effects of intraoperative and postanesthesia hypothermia on recovery in patients with large hepatocellular carcinoma（HCC） undergoing hepatectomy. Methods A total of 160 hypothermic patients were divided into three groups according to the severity of hypothermia：T＜35℃（n=41，group A1），35-35.5℃（n=85，A2） and 35.6-35.9℃（n=34，A3）.In a separate analysis，patients were divided into three groups according to the duration of hypothermia:：＜1 h （n=35，B1），1-2 h（n=47，B2），and＞2 h（n=78，B3）.Postanesthesia recovery time，first postoperative peritoneal drainage volume，5th postoperative ALT and AST levels，wound healing time and duration of postoperative hospitalization were compared among the groups. Results Anesthestia recovery time was longer in A1 than in the other A groups， and longer in B3 than in the other B groups.First postoperative peritoneal drainage was higher and 5th postoperative ALT levels were lower in A1 and B3 than in the respective A and B groups（P＜0.05）.Group A3 showed the lowest 5th postoperative ALT level and longest wound healing and postoperative hospitalization（P＜0.05）. Conclusion Body temperature ＜35℃ significantly affects patient recovery.Greater attention should be paid to body temperature monitoring and effective rewarming in order to minimize postoperative complications due to hypothermia.    Related Articles | Metrics

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Application of Microsoft Office Powerpoint combined with  problem-based learning teaching method in definition of the target volumes of nasopharyngeal carcinoma teachin LIU Lian-hua,HUANG Bing-jian 2014, 6 (1):  77-79.  doi: 10.3969/j.issn.1674-5671.2014.01.20 Abstract ( 355 )   PDF (281KB) ( 623 )   Save Related Articles | Metrics

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Research progress on sentinel lymph node guiding axillary lymph node dissection in patients with breast cancer LUO Zhou,XU Tao,YUN wen,LI Jian,LI li,TANG Jin-hai 2014, 6 (1):  80-83.  doi: 10.3969/j.issn.1674-5671.2014.01.21 Abstract ( 411 )   PDF (311KB) ( 769 )   Save Related Articles | Metrics

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Dendritic cell-based immunotherapy for non-small cell lung cancer CHEN Xing-long,WANG Xin,DONG Ming,LI Guang 2014, 6 (1):  83-86.  doi: 10.3969/j.issn.1674-5671.2014.01.22 Abstract ( 413 )   PDF (301KB) ( 515 )   Save Related Articles | Metrics

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Research progress on endometrial carcinoma and insulin resistance TANG Qiao-qiao,SONG Hong-lin,ZHANG Jie-qing 2014, 6 (1):  86-89.  doi: 10.3969/j.issn.1674-5671.2014.01.23 Abstract ( 387 )   PDF (290KB) ( 544 )   Save Related Articles | Metrics

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The role of heat shock proteins in prevention and treatment of tumor LIU Xin-wen,ZHOU Xiao-qin,HUANG Zhen-guang,YANG Yu-fang 2014, 6 (1):  90-93.  doi: 10.3969/j.issn.1674-5671.2014.01.24 Abstract ( 418 )   PDF (307KB) ( 519 )   Save Related Articles | Metrics

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Application of fast tract surgery on the perioperative period of  primary liver cancer LIANG Yong-rong,XIANG Bang-de 2014, 6 (1):  93-96.  doi: 10.3969/j.issn.1674-5671.2014.01.25 Abstract ( 341 )   PDF (328KB) ( 639 )   Save Related Articles | Metrics

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Nursing progress of obstruction of peripherally inserted central catheter  in patients with tumor CHEN Zhi-ling,JIANG Jin-fang 2014, 6 (1):  96-98.  doi: 10.3969/j.issn.1674-5671.2014.01.26 Abstract ( 355 )   PDF (304KB) ( 718 )   Save Related Articles | Metrics

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Increased miR-221 expression in hepatocellular carcinoma tissues and its role in enhancing cell growth and inhibiting apoptosis in vitro RONG Min-hua,DANG Yi-Wu 2014, 6 (1):  99-100.  doi: 10.3969/j.issn.1674-5671.2014.01.27 Abstract ( 305 )   PDF (213KB) ( 467 )   Save Related Articles | Metrics