Abstract: Objective To evaluate the safety and therapeutic value of CT-guided radiofrequency ablation （RFA） in the treatment of pulmonary malignancies. Methods A total of 88 patients with lung malignancies， who altogether had 96 lesions， were treated using CT-guided RFA. The cohort included 14 cases of metastatic lung carcinoma and 74 cases of primary non-small cell lung cancer （NSCLC），which comprised various pathological types （23 cases of squamous cell carcinoma，48 adenocarcinoma，2 mixed carcinoma and 1 large cell carcinoma） and tumor sizes（≤3 cm，31 cases；3-5 cm，56 cases；>5 cm，9 cases）. Results Lesions in most patients became larger and showed fuzzy edges after RFA；some lesions showed bubble-like changes. Follow-up CT at 6 months showed that all 96 lesions had shrunk， with an overall efficacy of 91.6%. The 1-year local control rate was 88.0%， and the 1-year survival rate was 95.5%. Conclusion CT-guided percutaneous RFA is a safe，effective and minimally invasive therapy for treating pulmonary malignancies.

Key words: Lung neoplasm, Radiofrequency ablation, Metastatic carcinoma of lung, Tomography, X-ray computed