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25 September 2014, Volume 6 Issue 3 Previous Issue    Next Issue

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Tumor diagnosis and treatment: the present and future LIN Yuan 2014, 6 (3):  219-223.  doi: 10.3969/j.issn.1674-5671.2014.03.01 Abstract ( 429 )   PDF (484KB) ( 797 )   Save Related Articles | Metrics

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Microarray-based screening to identify differentially expressed microRNAs associatedwith early recurrence of hepatocellular carcinoma after curative resection JIANG Jing-hang,GUO Zhe,YANG Hao-jie,YANG Fu-quan,BAO Si-yang,LI Le-qun,YANG Ri-rong,XIANG Bang-de 2014, 6 (3):  224-229.  doi: 10.3969/j.issn.1674-5671.2014.03.02 Abstract ( 312 )   PDF (451KB) ( 699 )   Save Objective To screen for differentially expressed microRNAs associated with early recurrence of hepatocellular carcinoma （HCC）. Methods Tissue samples were taken from 10 HCC patients who had undergone curative resection， comprising 5 patients who experienced early recurrence and 5 who did not. In addition， normal tissue from 4 individuals without HCC served as control samples. All samples were analyzed using microarrays to identify microRNAs specifically expressed in early-recurrence HCC. Results Several microRNAs were significantly upregulated in early-recurrence HCC relative to normal tissue：miR-21-3p，miR-21-5p，miR-222-3p，miR-3182，miR-3651，miR-3654，miR-4451，miR-4633-5p，and miR-720. Conversely，miR-4525 was significantly downregulated in early-recurrence HCC relative to normal tissue. Relative to normal tissue，several microRNAs were significantly upregulated in non-early-recurrence HCC（miR-106b-5p，miR-3651，miR-4451，miR-93-5p） or downregulated（miR-3692-5p，miR-451a）. Conclusion MicroRNAs may play a key role in early recurrence of HCC after curative resection. Related Articles | Metrics

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Celastrol-mediated growth inhibition of subcutaneously transplanted hepatocarcinoma in nude mice LI Jing-yuan,WU Liu-cheng,ZHENG Bo,SHAO Yi-xiang 2014, 6 (3):  230-234.  doi: 10.3969/j.issn.1674-5671.2014.03.03 Abstract ( 390 )   PDF (669KB) ( 593 )   Save  Objective To study the potential of celastrol to inhibit growth of transplanted tumors in nude mice. Methods Nude mice（n=20） subcutaneously injected with HepG2 cells were randomly divided into 4 groups and treated by abdominal injection with 0，1.0，2.0 and 4.0 mg/kg once daily five times per week. Tumor size was measured every five days. Results Tumor volume inhibition was 12.21% for 1.0 mg/kg，65.60% for 2.0 mg/kg and 89.52% for 4.0 mg/kg，and tumor volume was significantly smaller in animals treated with 2.0 or 4.0 mg/kg than in control animals. Severe liver and kidney toxicity were observed in animals treated with 4.0 mg/kg. Conclusion Celastrol shows good anticancer activity in this mouse model of liver cancer. Studies are needed to optimize dosing and drug structure to reduce toxicity. Related Articles | Metrics

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Proteomic analysis of aflatoxin B1-related hepatocellular carcinoma in the FuSui area of  Guangxi，China HUANG Xin-fei,LING Yong-chi,QI Lu-nan,OU Chao 2014, 6 (3):  235-243.  doi: 10.3969/j.issn.1674-5671.2014.03.04 Abstract ( 330 )   PDF (698KB) ( 487 )   Save Objective To establish specific molecular marker profiles of aflatoxin B1（AFB1）-related hepatocellular carcinoma （HCC）by comparing protein expression profiles between AFB1-related and non-AFB1-related HCC in the FuSui area of Guangxi. Method A total of 24 patients with AFB1-related HCC and 16 patients with non-AFB1-related HCC group were analyzed by isobaric tagging reagent （iTRAQ） quantitative proteomics together with 2DLC-MS/MS in order to identify differences in protein expression levels.In parallel，normal liver tissue from 10 patients who were liver donors，who had hepatic hemangioma or who had undergone liver resection was analyzed as a control. Results A total of 88 unique proteins were identified that were ≥2-fold overexpressed（51 proteins） or≤0.5-fold underexpressed（37 proteins） in AFB1-related HCC tissue relative to control tissue.Of the 88 proteins，50 were expressed at similar levels in AFB1-related HCC and non-AFB1-related HCC tissue，while 38 were associated with pathological features.Based on gene ontology analysis， most of the 88 proteins are predicted to play roles as binding proteins and catalysts.Most are located in the cytoplasm，nucleus or mitochondria，and most are involved in detoxification，drug metabolism and anti-apoptotic pathways. Conclusions This study has identified several differentially expressed proteins associated with AFB1-related HCC in the FuSui area of Guangxi，which may provide clues to understanding AFB1-related hepatocarcinogenesis in this part of the world. Related Articles | Metrics

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Early cancer screening and treatment in Changsha， China: assessment for 2012-2013 XIE Qiang-ming,LIU Kun,CHEN Shan 2014, 6 (3):  243-246.  doi: 10.3969/j.issn.1674-5671.2014.03.05 Abstract ( 363 )   PDF (294KB) ( 570 )   Save Objective  To examine whether early cancer diagnosis and treatment can help reduce the increasing incidence of cancer in cities，we evaluated the results of a survey in Changsha，China concerning the detection and treatment of common cancers of the lung，breast，colon，upper gastrointestinal tract and liver. Methods A survey of residents aged 40-69 years in five districts of Changsha was conducted in 2012-2013 to identify high-risk cancer populations，and individuals assessed to be at high risk of one or more cancers were screened using low-dose spiral CT，breast and liver ultrasound， mammary molybdenum target，or endoscopy as appropriate. Results The implementation of high-risk assessment included 50 000 people and the cancer screening included 10 136 person-time； this investment varied by target organ as follows: lung，3 220 person-time；liver，3 109 person-time；breast，2 057 person-time；esophagus and stomach，1 018 person-time；large intestine，732 person-time.Precancerosis was detected in 1 279 cases，and the positive rate was 12.62%. A total of 47 suspected cancer patients were screened，and the positive rate was 0.46%. Precancerosis and cancer showed different prevalences by tissue type：precancerous lung lesions were found in 902 individuals，and the positive rate was 28.01%；lung cancer was found in 15 cases，and the positive rate was 0.47%；precancerous liver lesions were found in 4 cases，and the positive rate was 0.13%；liver cancer was found in 9 cases，and the positive rate was 0.29%；precancerous large intestine lesions were found in 106 cases， and the positive rate was 14.48%；colorectal cancer was found in 5 cases，and the positive rate was 0.68%；precancerous upper gastrointestinal tract lesions were found in 23 cases，and the positive rate was 2.26%；upper gastrointestinal tract cancer was found in 2 cases，and the positive rate was 0.20%；precancerous breast lesions were found in 244 cases，and the positive rate was 11.86%； and breast cancer was found in 16 cases， and the positive rate was 0.78%. Conclusions Targeted efforts to screen for and diagnose cancer early in cities can be an effective way to increase the rate of early treatment， survival and quality of life. Related Articles | Metrics

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Clinical study of dinitrophenyl-modified autologous tumor vaccine to treat advanced malignant melanoma CHEN Dian-jun,LI Xiao-song,ZHAO Hui,FU Yan,HU Jia,QI Nan,SHI Xiu-li,DU Nan 2014, 6 (3):  247-252.  doi: 10.3969/j.issn.1674-5671.2014.03.06 Abstract ( 396 )   PDF (397KB) ( 529 )   Save Objective To investigate the efficacy of autologous tumor vaccine modified to carry the dinitrophenyl hapten to treat advanced malignant melanoma. Methods Clinical data were retrospectively analyzed for 84 patients who underwent resection for stage Ⅲb，Ⅲc or IV malignant melanomas. Patients were divided into two groups depending on whether or not their biochemotherapy was supplemented with dinitrophenyl-modified autologous tumor vaccine. The two groups were compared in terms of the following parameters：relative numbers of CD4+CD25+ regulatory T cells and lymphocyte subsets in peripheral blood， which were determined using flow cytometry；observed strength of delayed type hypersensitivity（DTH）；and clinical outcomes such as overall survival（OS） and disease-free survival （DFS）. Results The subpopulations of CD4+-IFN-γPE and CD8+-IFN-γPE lymphocytes were significantly larger in the vaccinated patients than in the biochemotherapy-only patients（P<0.05），while the relative proportions of CD4+CD25+ regulatory T cells were significantly smaller（P<0.05）. DTH-positive response（defined as spot size ≥5 mm） occurred in 94.6% of vaccinated patients but in only 45% of biochemotherapy-only patients（P<0.05）. The 1-，2- and 3-year survival rate were 95.0%，73.0 and 65.5% in the vaccinated group,respectively，90.1%，59.0%and 43.5% in the biochemotherapy-only group,respectively. OS and DFS in the vaccinated group were 79.3% and 81.1%，compared to 64.2% and 81.1% in the biochemotherapy-only group. The difference in OS between the two groups was significant （P<0.05）. Conclusion Administering autologous tumor vaccine modified with the dinitrophenyl hapten may increase the overall survival of patients with specific cell-mediated melanoma，and it appears to do so by en-hancing their immune response and inhibiting immune tolerance. Related Articles | Metrics

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Clinical and prognostic significance of hTERT expression in patients with colorectal cancer XIE Xue-cheng,QIU Hai,TANG Fan,GE Lian-ying,QIN Yu-zhou 2014, 6 (3):  252-257.  doi: 10.3969/j.issn.1674-5671.2014.03.07 Abstract ( 365 )   PDF (557KB) ( 479 )   Save Objective To investigate the expression profile of human telomerase reverse transcriptase （hTERT） in colorectal cancer （CRC） and to assess its clinical significance. Methods Quantitative real-time PCR was used to detect expression of hTERT mRNA both in colorectal cancer and in corresponding normal tissue. Expression data were correlated with clinicopathological features，and survival analysis was performed to assess the prognostic significance. Results The hTERT mRNA was expressed in both tumor and CRC tissue，but it was expressed at significantly higher levels in cancer tissue（P=0.011）. Upregulation of hTERT was significantly associated with lymph node involvement （P=0.011） and TNM stage （P=0.006）. Kaplan-Meier survival analysis of low vs. high expressers of hTERT revealed much lower survival among high expressers（P=0.014）. Conclusions The results of the current study suggest that hTERT may play an important role in onset of CRC，so the protein may have potential as a prognostic biomarker or even as a therapeutic target. Related Articles | Metrics

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Clinical observations of patient-controlled butorphanol intravenous analgesia following surgery to remove malignant tumors from the lymph node basin and abdomen LI Yang,QIAN Wei,DU Xue-ke,PENG Dan-hui,PEI Sheng-lin,CHEN Xiao-dong,PAN Ling-hui,HUANG Bing 2014, 6 (3):  257-260.  doi: 10.3969/j.issn.1674-5671.2014.03.08 Abstract ( 400 )   PDF (282KB) ( 630 )   Save Objective To examine the therapeutic efficacy and adverse events associated with butorphanol during postoperative patient-controlled intravenous analgesia （PCIA）. Methods A total of 240 patients treated by radical surgery to remove malignant tumors in the lymph node basin and abdomen were randomized into 8 groups of 30 patients each. Groups A1-A6 performed PCIA with different doses of butorphanol［（1.6，2.0，2.4，2.8，3.2 and 3.6 μg/（kg·h）］. Group B1 performed PCIA with morphine，while group B2 received intramuscular injections of morphine. At 24 h after analgesia， self-reported pain assessments were made using the Visual Analogue Scale（VAS），Bruggmann Comfort Scale（BCS）and Ramsay score. Side effects of PCIA were assessed at the same time. Results Groups A1 and A2 had significantly higher VAS scores（5.58±0.94 and 5.22±0.86） than group B2（P＜0.05）and significantly lower BCS scores（1.92±0.92 and 1.79±0.79；P＜0.05）. Conversely，groups A3-A6 and group B1 had lower VAS scores and higher BCS scores than group B2. Ramsay scores were highest in groups A5 （3.33±1.28） and A6（4.13±1.21）. Nausea，vomiting，and abdominal distension occurred to a much lower extent in in groups A1-A3 than in the other groups. Incomplete analgesia occurred to a much lower extent in groups A3-A6 and B1 than in groups A1-A2. Conclusion Butorphanol shows satisfactory analgesic efficacy in PCIA and is associated with lower incidence of adverse reactions (sedation, nausea, vomiting, abdominal distension) than morphine. Related Articles | Metrics

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Methylation of the PCDH8 promoter and Dnmt1 expression in gastric cancer YU Yun-peng,LI Chang-yan,HUANG Guan-nan,JIANG Xiang-jun 2014, 6 (3):  261-264.  doi: 10.3969/j.issn.1674-5671.2014.03.09 Abstract ( 326 )   PDF (431KB) ( 526 )   Save Objective To investigate the relationship of gastric carcinogenesis to promoter methylation and expression of the Proto-cadherin-8（PCDH8） gene，as well as to expression of Dnmt1 protein. Method Samples of cancerous and normal gastric mucosa were obtained surgically from 60 patients with primary gastric cancer. Methylation-specific PCR was used to determine the methylation status of the PCDH8 promoter，while immunohistochemistry was used to measure levels of PCDH8 and Dnmt1 proteins. Results Among the 60 patients，33（55.0%） showed a methylated PCDH8 promoter in samples of cancerous tissue，compared to only 2（3.3%） who showed a methylated promoter in normal samples（χ２=38.76，P＜0.001）.Methylation status of the PCDH8 promoter showed no significant association with patient age，sex，or TNM stage；methylation was， however， associated with lymph node metastasis（χ２=17.47，P＜0.001）. Gastric cancer tissue showed significantly lower levels of PCDH8 protein than normal tissue（11.7% vs 90.0%，χ２=73.65，P＜0.001） and significantly higher levels of Dnmt1 protein（73.3% vs 5.0%，χ２=58.79，P＜0.001）.In gastric cancer samples， the level of PCDH8 protein correlated negatively with that of Dnmt1 protein（r=-0.544，P＜0.001）. Conclusion Methylation of the PCDH8 promoter and elevated expression of Dnmt1 may be associated with the occurrence of gastric cancer. Related Articles | Metrics

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Comparison of gemcitabine alone and gemcitabine combined with Rh-endostatin as first-line treatment for elderly with advanced non-small cell lung cancer：a randomized controlled trial CHEN Qun,SHI Qin,XIE Qiang,XIAO Song 2014, 6 (3):  265-270.  doi: 10.3969/j.issn.1674-5671.2014.03.10 Abstract ( 377 )   PDF (350KB) ( 547 )   Save Objective To compare the efficacy and safety of gemcitabine alone or in combination with Rh-endostatin as a first-line treatment for elderly patients with advanced non-small cell lung cancer（NSCLC）. Methods A total of 128 elderly patients with pathology-confirmed，advanced NSCLC were recruited between 1 April 2009 and 31 May 2013 and randomized to receive gemcitabine alone （n=62） or gemcitabine with Rh-endostatin（n=66）. Therapeutic efficacy was evaluated strictly according to RECIST criteria after 2 treatment cycles，and median survival time（mOS）and median progression-free survival（mPFS）were recorded. Per-cycle safety and efficacy were evaluated for all subjects according to NCICTC 3.0 criteria. Results In the group receiving combination therapy，11 cases were PR，36 were SD，and 15 were PD.In the gemcitabine-alone group，6 cases were PR，26 were SD，and 24 were PD. Overall response rate was similar between the combination group and gemcitabine-alone group，in terms of both ITT（16.7% vs 9.7%，P=0.326） and PP（17.7% vs 10.7%，P=0.278）. However，the two groups differed significantly in DCR（PP）（75.8% vs 57.1%，P=0.031） and mPFS（4.0 vs 3.7 months，P=0.027），and mOS was similar between the two groups（9.1 vs 8.5 months，P=0.418）. Major toxic effects included bone marrow aplasia，such as neutropenia and anemia，which generally correlated with the chemotherapy regimen（most were G 1/2；a few were G 3/4）. Conclusion The combination of gemcitabine and Rh-endostatin offers therapeutic benefits to elderly patients with advanced NSCLC and may be reasonably tolerated by most patients. Related Articles | Metrics

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To evaluate the efficiency of CT-guided radiofrequency ablation to treat pulmonary malignancies CHEN Shi-lin,XU Lin,ZHANG Qin,FENG Dong-jie,QIN Jin-xia,YAN Xin-yao,LI Yang,SUN Lei,FENG Yong,ZHANG Jin,ZHUANG Yi-ping 2014, 6 (3):  271-274.  doi: 10.3969/j.issn.1674-5671.2014.03.11 Abstract ( 436 )   PDF (357KB) ( 523 )   Save Objective To evaluate the safety and therapeutic value of CT-guided radiofrequency ablation （RFA） in the treatment of pulmonary malignancies. Methods A total of 88 patients with lung malignancies， who altogether had 96 lesions， were treated using CT-guided RFA. The cohort included 14 cases of metastatic lung carcinoma and 74 cases of primary non-small cell lung cancer （NSCLC），which comprised various pathological types （23 cases of squamous cell carcinoma，48 adenocarcinoma，2 mixed carcinoma and 1 large cell carcinoma） and tumor sizes（≤3 cm，31 cases；3-5 cm，56 cases；>5 cm，9 cases）. Results Lesions in most patients became larger and showed fuzzy edges after RFA；some lesions showed bubble-like changes. Follow-up CT at 6 months showed that all 96 lesions had shrunk， with an overall efficacy of 91.6%. The 1-year local control rate was 88.0%， and the 1-year survival rate was 95.5%. Conclusion CT-guided percutaneous RFA is a safe，effective and minimally invasive therapy for treating pulmonary malignancies. Related Articles | Metrics

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Comparison of dosimetry achieved using volumetric modulated arc therapy or static intensity-modulated radiotherapy to treat esophageal neoplasm HE Zhi-jie,WANG Xiao-min,ZHAO Yi-dian,SUN Xiu-ke,WANG Hui-tao,ZHANG Qiang,CHEN Long 2014, 6 (3):  275-279.  doi: 10.3969/j.issn.1674-5671.2014.03.12 Abstract ( 405 )   PDF (337KB) ( 628 )   Save Objective To compare the feasibility of using volumetric modulated arc therapy（VMAT） or static intensity-modulated radiotherapy（IMRT）to treat advanced esophageal neoplasm. Methods A consecutive series of 37 patients newly diagnosed with esophageal neoplasm was analyzed by computed tomography， and the resulting images were input into the oncentra planning system to generate protocols for IMRT and VMAT. All 37 patients received both types of treatment. Dose-volume histograms were generated to compare gross tumor volume（GTV），planning target volume（PTV） and exposure of at-risk organs. Different results for each method were assessed for statistical significance using the paired t-test. Results VMAT gave slightly but not significantly higher values than IMRT for PTV-D98 （58.39±1.03 vs 58.51±0.57，P=0.314） and PTV-D2（65.92±1.57 vs 66.17±1.25，P=0.230）. VMAT was associated with significantly lower GTV D98 （60.03±1.23 vs 62.46±1.03，P<0.001），D2 （64.83±0.91 vs 66.08±1.01，P=0.001），and Dmean（63.62±1.28 vs 64.07±1.08，P=0.021）. VMAT also gave significantly lower PTV-V105 coverage（t=-8.216，P<0.001）. The two methods were associated with similar conformity index （t=-0.147，P=0.884），homogeneity index （t=2.56，P=0.89），spinal dose （P=0.743） and heart dose（P=0.519）. VMAT was associated with lower lung V20 than IMRT（t=-12.690，P<0.001），as well as lower lung V30（t=-2.870，P=0.007） and lower mean lung dose（t=-3.659，P=0.001）. Mean MU was 24% lower with VMAT than with IMRT （572.33 vs 754.95）. Conclusion In patients with esophageal neoplasms，VMAT can provide equivalent or superior dose distributions compared to IMRT，and it can generate more and better GTV hotspots. VMAT is also associated with lower lung V20 and V30，lower MU， and higher delivery efficiency. These findings suggest that VMAT has strong potential for treating esophageal cancer. Related Articles | Metrics

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Diagnostic value of ultrasound and serum levels of CA125 in ovarian cance ZHANG Jun,MA Yan,MA Hai-ying,CHEN Dong-xiu,LI Jing-jing 2014, 6 (3):  280-284.  doi: 10.3969/j.issn.1674-5671.2014.03.13 Abstract ( 332 )   PDF (391KB) ( 505 )   Save Objective To explore the value of ultrasound and serum levels of CA125 in ovarian cancer diagnosis. Methods A consecutive series of 113 patients with ovarian tumor treated between October 2012 and December 2013 were analyzed. Patients included 53 cases of malignancy and 60 cases of benign tumors; all were diagnosed based on ultrasound and serum levels of CA125 one week before surgery，and then definitively diagnosed based on postoperative pathology. To adjust for baseline differences between the two groups， propensity-score matching was used to generate 34 pairs of patients. Results Serum CA125 assay showed the following diagnostic performance：sensitivity，88.2%；specificity，61.8%，PPV，69.8%；NPV，84.0%；and accuracy，75.0%. The corresponding values for ultrasound were 85.3%，88.2%，87.9%，85.7% and 86.8%. The corresponding values for the combination of serum CA125 assay and ultrasound were 94.1%，64.7%，72.7%，91.7% and 79.4%. Ultrasound alone showed significantly higher specificity than either serum CA125 alone or the combination of both methods（P＜0.05）. However，sensitivity，PPV，NPV and accuracy were similar across all three diagnostic methods（P＞0.05）. Conclusion Combining ultrasound with serum CA125 assay does not improve diagnostic accuracy. Related Articles | Metrics

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Clinical analysis of cryptococcal meningitis in patients with malignant tumors LIU Chen,HUANG Yun,LI Zhi-wen 2014, 6 (3):  284-288.  doi: 10.3969/j.issn.1674-5671.2014.03.14 Abstract ( 312 )   Save  Objective To analyze the clinical features of cryptococcal meningitis in cancer patients as well as the risk factors for this disease. Methods Clinical data for 32 patients with malignant tumors and cryptococcal meningitis were retrospectively analyzed using single-and multiple-factor logistic regression. Results The most frequent symptoms of cryptococcal meningitis were fever and headache. Other than significantly elevated cerebrospinal fluid pressure，patients with cryptococcal meningitis did not show any specific signs or symptoms based on routine examination of cerebrospinal fluid，biochemical tests，computed tomography or magnetic resonance imaging. Cryptococcal meningitis was able to be confirmed by detecting cryptococcus in cerebrospinal fluid by microscopy or in a culture test. Multifactorial analysis identified the following factors as significant predictors of whether a patient would suffer cryptococcal meningitis（P＜0.05）：to what extent bone marrow was suppressed，whether broad-spectrum antibiotics were administered quickly after onset of symptoms， whether the patient received both chemotherapy and radiotherapy，whether the patient underwent an invasive operation， and whether the patient had reduced albumin levels or was in poor physical condition. Conclusion Decreasing the rate of cryptococcal infection of patients with malignant tumors involves reducing or eliminating risk factors， strengthening immunity and providing supportive care. Early diagnosis of infection and early antifungal therapy can improve the prognosis of cancer patients with cryptococcal meningitis. Related Articles | Metrics

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Expression and clinical significance of HIF-1α and BCRP in invasive ductal carcinoma REN Xiang,SHU Chun-gui 2014, 6 (3):  289-291.  doi: 10.3969/j.issn.1674-5671.2014.03.15 Abstract ( 348 )   PDF (338KB) ( 588 )   Save Related Articles | Metrics

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Clinical observation of nedaplatin combined with paclitaxel as the first-line treatmentin advanced esophageal squamous carcinoma HENG Wei-sheng,PANG Hong-xia,KE Qiu-qing,HONGYan-ni,YANG Hong-kui,ZHOU Wen-bin 2014, 6 (3):  292-294.  doi: 10.3969/j.issn.1674-5671.2014.03.16 Abstract ( 431 )   PDF (288KB) ( 453 )   Save Related Articles | Metrics

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Clinical evaluation of modified FOLFIRI regimen every three weeks as maintenance treatment for metastatic colorectal cancer TONG Gang-ling,YU Shao-kang,HE Yan-ling,SHEN Dong-lan,WANG Shu-bin 2014, 6 (3):  295-297.  doi: 10.3969/j.issn.1674-5671.2014.03.17 Abstract ( 325 )   PDF (281KB) ( 664 )   Save Related Articles | Metrics

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Survey of grief reactions among bereavement by cancer WANG Hai-ying,WANG Jun-hui 2014, 6 (3):  298-301.  doi: 10.3969/j.issn.1674-5671.2014.03.18 Abstract ( 298 )   PDF (316KB) ( 622 )   Save Related Articles | Metrics

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Evolution，production and clinical application of lentiviral vectors TANG Yong，LIANG Xia，WANG Qi 2014, 6 (3):  301-305.  doi: 10.3969/j.issn.1674-5671.2014.03.19 Abstract ( 359 )   PDF (317KB) ( 554 )   Save Related Articles | Metrics

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Research progress on the relationship between the gap junction intercellular communication and hepatocellular carcinoma ZHAO Yu,YANG Yan,ZHANG Kai 2014, 6 (3):  306-310.  doi: 10.3969/j.issn.1674-5671.2014.03.20 Abstract ( 330 )   PDF (331KB) ( 435 )   Save Related Articles | Metrics

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microRNAs and colorectal cancer XIE Xue-cheng,QIU Hai,QIN Yu-zhou 2014, 6 (3):  310-314.  doi: 10.3969/j.issn.1674-5671.2014.03.21 Abstract ( 299 )   PDF (295KB) ( 394 )   Save Related Articles | Metrics

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Research progress in gastric cancer stem cell YANG Xi-hua，CHEN Jian-si 2014, 6 (3):  315-318.  doi: 10.3969/j.issn.1674-5671.2014.03.22 Abstract ( 305 )   PDF (288KB) ( 567 )   Save Related Articles | Metrics

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Progress of diagnosis and treatment of mammary intraductal papilloma LIANG Jian-xiong 2014, 6 (3):  318-321.  doi: 10.3969/j.issn.1674-5671.2014.03.23 Abstract ( 374 )   PDF (327KB) ( 865 )   Save Related Articles | Metrics

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Association between airway exposure of aflatoxin and serum concentration LAI Hao 2014, 6 (3):  322-322.  doi: 10.3969/j.issn.1674-5671.2014.03.24 Abstract ( 322 )   PDF (208KB) ( 326 )   Save Related Articles | Metrics