Abstract: Objective To analyze human hepatocellular carcinoma tissue using proteomics to identify possible deregulated networks of protein-protein interactions. Methods PubMed was searched using keywords “hepatocellular carcinoma” and “proteomics” to identify reports of proteins that are deregulated in the cancerous state. Then the proteins were analyzed for interactions using PRINCESS. Results Nine protein-protein interactions involving 8 proteins were assigned confidence scores >2.0：APEX1 interacts directly with ILF2，PRDX3，ANP32A，and MATR3 and indirectly with IQGAP2. SULT1A1 interacts directly with PDIA6. Conclusion APEX1，ILF2，PRDX3，ANP32A，MATR3，and IQGAP2 may participate in a single network associated with onset and/or progression of hepatocellular carcinoma.

Key words: Hepatocellular carcinoma, Deregulated proteins, Protein-protein Interaction, Biological pathway