Abstract:

Objective To study the genotype distribution of hepatitis B virus （HBV） in patients from the Fusui area of China in order to guide prevention and treatment efforts. Methods A total of 40 patients with liver cancer and 245 HBV carriers were analyzed using nested PCR to amplify the HBV S region. The amplicons were sequenced and analyzed in sequence alignments with published HBV genotypes. Result Of the 285 participants，59（20.7%） were infected with genotype B virus，223（78.2%） with genotype C，and 3 （1.1%） with an undefined genotype. Of the 282 participants with either genotype B or C virus，men accounted for 40 with genotype B and 158 with genotype C；women accounted for 19 with genotype B and 65 with genotype C. The gender distribution was similar for these two genotypes （P>0.05）. Among liver cancer patients，10 （25%） had genotype B and 30 （75%） had genotype C；among HBV carriers，49（20.25%） had genotype B and 193（79.75%） had genotype C. Stratification of patients into four age groups （＜30 years，30-40 years， 40-55 years，and >55 years），The distribution of these two genotypes was similar in the four age groups（P>0.05）. Conclusion HBV genotype C predominates in the Fusui area，followed by genotype B，with no other types observed. Genotypes B and C are distributed similarly among individuals of different age and gender.