Abstract:

Objective We aimed to explore target genes and molecular mechanisms potentially affected by miR?鄄10b?鄄5p in the devel?鄄opment of pancreatic cancer. Methods We predicted potential target genes affected by miR?鄄10b?鄄5p using the Gene Expression Omnibus database and other online prediction databases. Results A total of 586 candidate target genes were identified，and Gene Ontology enrichment analysis showed that many target genes are involved in protein transport. Pathway analysis using the Kyoto Encyclopedia of Genes and Genomes suggested that miR?鄄10b?鄄5p is involved in tumor?鄄associated pathways as well as specifically in pancreatic cancer?鄄related pathways. Network analysis using the Protein?鄄Protein Interaction tool suggested interactions among seven mutant genes （EGFR，RAC3，SMAD4，PIK3CA，CDK6，Bcl2L1，STAT3） in pancreatic cancer?鄄related pathways. Conclusions The microRNA miR?鄄10b?鄄5p may target genes and pathways involved in pancreatic cancer，potentially making it important in diagnosis and treatment of the disease.

Key words: Pancreatic neoplasms, miR-10b-5p, Bioinformatics, Target genes, Molecular mechanism