Abstract:

Objective To analyze the clinical characteristics，outcomes and treatment strategies of a case series of patients with primary testicular diffuse large B-cell lymphoma（PTDLBCL）. Methods Various clinical parameters were analyzed in 9 patients with PTDLBCL diagnosed from January 2013 to September 2016 in our hospital. Results Median age at diagnosis was 64 years （range，50-72）. Cases involved mainly the right testicle，and cells of origin were  non-GCB subtype（7 patients） or GCB subtype（2 patients）.Median rate of Ki-67 expression was 80%.One patient underwent surgery only，while seven had surgery followed by chemotherapy. Six patients showed complete response；two，partial response；and one，progression.Six patients were alive，corresponding to follow-up ranging from 5 to 34 months. Conclusion PTDLBCL has high recurrence risk. We suggest first-line treatment involving 6-8 cycles of anthracycline-based chemotherapy and rituximab treatment，central nervous system prophylaxis and contralateral testicular radiation after surgery.

Key words:  Lymphoma, Primary testicular diffuse large B-cell lymphoma, Chemotherapy, Clinical characteristic, Prognosis