Abstract:

Objective To observe changes in angiopoietin-1（ANGPT1） expression in lung adenocarcinoma and investigate the potential clinical significance. Methods A total of 51 cancer tissue samples and adjacent normal tissues were collected from lung adenocarcinoma patients；in addition，11 non-cancer normal tissues were collected. Relative levels of ANGPT1 mRNA were assessed using quantitative real-time PCR，and possible relationships between ANGPT1 mRNA and clinicopathology were explored. Results Relative levels of ANGPT1 mRNA were 0.068±0.044 in lung adenocarcinoma tissue，0.696±0.157 in adjacent normal tissue，and 1.158±0.332 in non-cancer normal tissue（F=114.34，P<0.05）. Levels of ANGPT1 mRNA in lung adenocarcinoma tissues were not related to gender，age，or degree of differentiation（P>0.05），but they were related to TNM stage and lymphatic metastasis（P<0.05）. Conclusion ANGPT1 expression is reduced in lung adenocarcinoma，which may be involved in disease onset and development.

Key words: Lung neoplasms, Lung adenocarcinoma, Angiopoietin-1, Quantitative real-time PCR