Abstract:

Objective To explore the relationship between the ultrasonic real-time shear wave elastography and molecular subtypes of breast invasive ductal carcinoma. Methods A total of 137 patients（139 nodules） with breast invasive ductal carcinoma were confirmed by operation or gross needle biopsy. Ultrasonic real-time shear wave elastography was performed，and the relationship between the maximum elastic modulus value and molecular subtypes were analyzed. Results The maximum value of shear wave elas-tic modulus in Luminal type A，Luminal type B，HER-2 overexpression type，triple negative type were getting larger. The maximum value of shear wave elastic modulus differed significantly between the triple negative type and the Luminal A，B types（P＜0.05）.Spearman correlation analysis showed that the maximum value of ultrasonic real-time shear wave elastic modulus was significantly correlated with molecular subtypes（r=0.510，P=0.003）. Conclusion The maximum value of ultrasonic real-time shear wave elastic modulus have a certain value in distinguish of molecular subtypes in breast invasive ductal carcinoma.

Key words: Breast invasive ductal carcinoma, Real-time shear wave elastography, Elastic modulus value, Pathological molecular typing