Abstract: Objective To analyze the cancer incidence and mortality in Guangxi cancer registration areas in 2016. Methods The data of 31 cancer registration areas in Guangxi in 2016 were collected. Cancer incidence and mortality stratified by area（urban/rural），gender and age were analyzed. Crude rate，age-standardized rate（ASR），cumulative rate（0-74 years） and truncated rate were calculated. The proportions and rates of the top 10 cancers in different groups were also calculated. Age-standardized incidence and mortality rates were calculated using the Chinese population census in 2000 and Segi's population. Results The 31 cancer registration areas covered a total of 11，628，368 people（6，698，487 in urban areas and 4，929，881 in rural areas）. Among these people，28，140 new cancer cases were found，and the crude incidence rate，the ASR China，the ASR world and cumulative rate（0-74 years） were 241.99/10⁵， 196.89/10⁵，192.26/10⁵，and 21.90%，respectively. For either the ASR China or the ASR world，the incidence in male was higher than that in female，and the incidence in urban areas was higher than that in rural areas. Cancer incidence increased rapidly after 40 years old and reached the peak at the age group of 80 years old. The top ten cancers of incidence were liver，lung，breast，colorectum，cervix，stomach，nasopharynx，prostate，uterus and brain cancers，which accounted for about 75.65% of all new cancer cases. New cancer death cases amounted to 17，647，and the crude mortality rate，the ASR China，the ASR world and cumulative rate（0-74 years） were 151.76/10⁵，119.05/10⁵，117.31/10⁵，and 13.27%，respectively. For either the ASR China or the ASR world，the mortality in male was higher than that in female，and the incidence in urban areas was lower than that in rural areas. Cancer mortality increased rapidly after 40 years old and reached the peak at the age group of 85 years old. The top ten cancers of mortality included liver，lung，colorectum，stomach，breast，nasopharynx，cervix，esophagus，prostate，and leukemia，accounting for about 81.74% of all cancer death cases. Conclusions The incidence and mortality in Guangxi cancer registration areas in 2016 were slightly higher than 2015. Liver，lung，colorectum，breast，and nasopharynx cancers should be the focus of prevention and treatment.

Key words: Cancer, Cancer registry, Incidence, Mortality, Guangxi