Abstract: Objective To analyze the incidence and mortality of liver cancer in cancer registration areas of Heilongjiang Province and the trend of change. Methods The incidence and mortality data of liver cancer in the cancer registration areas of Heilongjiang Province from 2013 to 2017 were collected, and the incidence (mortality) rate, age-standardized incidence (mortality) rate and cumulative rate (0-74 years old) were calculated. The ASR was calculated based on the Chinese population census in 2000(ASR China) and Segi's world (ASR world) standard population. Annual percentage change (APC) was calculated by Joinpoint software. Results From 2013 to 2017, the incidence of liver cancer in the cancer registration areas of Heilongjiang Province was 29.13/105, the ASR China 17.18/105, and the cumulative rate (0-74 years old) 1.96%. The incidence of liver cancer in males (42.59/105) was higher than that in females (15.90/105), and the incidence of liver cancer in rural areas (35.05/105) was higher than that in urban areas (26.75/105). From 2013 to 2017, the mortality rate of liver cancer was 26.53/105, the ASR China 15.90/105, and the cumulative rate (0-74 years old) 1.78%. The mortality rate of liver cancer in males (38.33/105) was higher than that in females (14.93/105), and the mortality rate of liver cancer in rural areas (30.65/105) was higher than that in urban areas (24.88/105). From 2013 to 2017, the ASR China incidence showed a downward trend, while ASR China mortality showed no significant trend (P>0.05), and the male ASR China incidence showed a significant downward trend(P<0.05). Conclusions The burden of liver cancer in Heilongjiang Province is relatively heavy, the incidence rate is decreasing, and the mortality is relatively stable. More attention should be paid to male and rural areas with comprehensive prevention and controlling measures.

Key words: Liver cancer, Cancer registration, Incidence, Mortality, Heilongjiang