Abstract: Objective To analyze the epidemiological characteristics and disease burden of malignant tumors in Guangxi in 2019, and to provide reference for prevention and treatment of malignant tumors. Methods According to the tumor data reported by 56 cancer registration areas in Guangxi in 2019, the incidence, age⁃standardized rate by Chinese standard population (ASRC rate) of incidence, mortality and ASRC rate of mortality were calculated to analyze the incidence and mortality of malignant tumors in Guangxi in 2019. The indicators such as disability adjusted life years (DALYs) and years of life lost (YLLs) were calculated to assess the disease burden of malignant tumors. Results A total of 71,430 new cases of malignant tumors were reported in 56 cancer registration areas in Guangxi in 2019, with a crude incidence rate of 219.87/10⁵, ASRC rate of incidence was 172.17/10⁵; 45,485 mortality of malignant tumors were reported, with a crude mortality rate of 140.01/10⁵, ASRC rate of mortality was 105.25/10⁵. Cancers resulted in 660,930.15 DALYs in Guangxi in 2019, YLLs accounted for 97.4% of DALYs, the DALYs rate was 2,034.40 /105. In 2019, the incidence, mortality and DALYs rate of malignant tumors in Guangxi showed the characteristics of men higher than women, and urban areas higher than rural areas. In addition, in the 5 geographical areas of Guangxi, the highest incidence, mortality and DALYs rate of malignant tumors were in the north, south and west areas of Guangxi, respectively. The cancer of the liver, lung, female breast, colorectum, cervix, stomach, nasopharynx, uterus, prostate and thyroid were the top 10 for malignant tumors incidence, accounting for 75.3% of total cancer cases. The cancer of liver, lung, colorectum, stomach, female breast, cervix, nasopharynx, esophagus, leukemia and brain were the 10 leading causes of cancer deaths, accounting for 82.1% of total cancer deaths. Conclusions In 2019, the disease burden of malignant tumors in Guangxi is still at a high level, with significant regional differences and gender differences. The liver cancer, lung cancer, colorectum cancer, female breast cancer, cervix cancer and nasopharynx cancer are still the major malignant tumor for prevention and treatment in Guangxi. In addition, the incidence of thyroid cancer rises to the 10th place, more attentions should be paid and preventive measures should be taken early.

Key words: Malignant tumor')">Malignant tumor, Incidence, Mortality, DALYs, Disease burden