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25 September 2013, Volume 5 Issue 3 Previous Issue    Next Issue

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Breast cancer molecular subtypes and its individualize therapy TANG Jin-hai，CHEN Wei-xian 2013, 5 (3):  187-191.  doi: 10.3969/j.issn.1674-5671.2013.03.01 Abstract ( 494 )   PDF (443KB) ( 825 )   Save Related Articles | Metrics

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Clinical practice of sentinel lymph node biopsy in operated breast area ZUO Wen-shu，YANG Li 2013, 5 (3):  191-196.  doi: 10.3969/j.issn.1674-5671.2013.03.02 Abstract ( 405 )   PDF (450KB) ( 638 )   Save Related Articles | Metrics

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The application of Taxanes in the treatment of advanced breast cancer WEI Chang-yuan 2013, 5 (3):  197-200.  doi: Abstract ( 265 )   PDF (358KB) ( 698 )   Save Related Articles | Metrics

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Array-based comparative genomic hybridization analysis of patients with hepatocellular carcinoma related to hepatitis B virus and aflatoxin B1 exposure in Guangxi， China QI Lu-nan，CHEN Yuan-yuan，CHEN Zu-sun， BAI Tao，ZHU Hai，PENG Tao，LI Le-qun 2013, 5 (3):  201-210.  doi: 10.3969/j.issn.1674-5671.2013.03.04 Abstract ( 419 )   PDF (1333KB) ( 729 )   Save Objective To investigate genetic changes in individuals that may influence development of hepatocellular carcinoma （HCC） associated with hepatitis B virus（HBV）and exposure to aflatoxin B1 （AFB1）. Method Patients with HCC were divided into four groups based on HBV infection and AFB1 exposure status：HBV（+）/AFB1（+），n=10； HBV（+）/AFB1（-），n=10； HBV（-）/AFB1（+）， n=6； HBV（-）/AFB1（-），n=6.Array-based comparative genomic hybridization（Array CGH） was carried out on tumor tissue to identify genome-wide genetic changes. Result Among all 32 tissue samples，573 CNAs were identified， comprising 184 gains and 389 losses. Frequent gains were observed in the following regions： 1q，4p，5p，6p，7p，8q，10p，17q，20p，20q and X.Frequent losses were observed in the following regions：1p，2q，4q，8p，9p，10q，11q，13q，14q，16p，16q，17p，19p，19q，21q，22q and Y.A total of 25 RARs were de-tected： 8 RAR gains were 1q21.1-q44，5p13.2-p15.3，6p12.1-p25.2，7q21.1-q35，8q11.2-q24.3，17q12-q25.2，18q12.3-q22.3 and X； 17 RARs losses were 1p31.1-p36.2，2q23.2-q37.2，4q12-q35.2，6q14.1-q26，8p12-p23.2，9p21.1-p24.2，10q21.3-q26.2，13q12.1-q21.1， 14q21.3-q32.2，16p12.1-p13.2，16q12.1-q24.1，17p12-p13.3，19p13.1-p13.3，19q13.2-q13.4，21q21.3-q22.2，22q11.2-q13.2 and Y.Loss of 8p12-p23.2 was associated with higher TNM tumor stage（TNM Ⅰ-Ⅱ： 38.9% vs TNM Ⅲ：92.9%；P=0.038） and shorter tumor-free survival （P=0.045）.Loss of 4q13.3-q35.2 and 13q12.1-q21.2 and gain of 7q11.2-q35 occurred at higher frequency among HBV（+）/AFB1（+） patients than among the other groups. Univariate analysis found tumor-free survival to be associated with tumor size， serum AFP，BCLC，TNM stage，invasion and metastasis，and loss of 8p12-p23.2（all P<0.05）.Multivariate analysis revealed three of these fac-tors to be independently associated with tumor-free survival：serum AFP（≥400），TNM stage， and loss of 8p12-p23.2（all P≤0.045）. Conclusion Several chromosomal alterations were identified in the genomes of individuals with HCC in Guangxi.Loss of 19p13.1-p13.3 may be a characteristic feature of the disease in this part of China. Loss of 8p12-p23.2 may occur later during HCC progression and is associated with shorter tumor-free survival. Loss of 4q12-q35.2 and 13q12.1-q21.1 and gain of 7q21.1-q35 may be associated with the synergistic hepatocarcinogenic effect of HBV infection combined with AFB1 exposure. Related Articles | Metrics

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Dynamic expression of resistance genes during Cisplatin resistance process of ovarian cancer SHI Li-jun，YU Hong-ji，LI Li，WANG Qi 2013, 5 (3):  210-215.  doi: 10.3969/j.issn.1674-5671.2013.03.05 Abstract ( 641 )   PDF (535KB) ( 789 )   Save Objective To study the dynamic expression of resistance genes during chemotherapy resistance process，so as to provide evidences for exploring reversal targets and reversal treatment. Methods Adopt Benjamini-Hochberg（BH）to analyse expression profile data of ovarian cancer who provided by TCGA，then use KEGG of DAVID to enrich the pathway，then employ T test to measure them again，use COREMINE to select some genes which is associated with multiple drug resistant and drug resistance of neoplasm.Take the differentially expressed gene to conduct survival analysis，find out the genes which is significant. Then employ qRT-PCR to examine the expression of them in SKOV3-GFP and SKOV3/DDPⅱtumor. Result 306 differentially expressed genes were found in Microarray，of which 110 had increased expression and 196 had low  expression. KEGG of DAVID enrichment 5 up-regulate-pathway and 4 down-regulate-pathway.T test sift out 18 up-regulate genes and 19 down-regulate genes.COREMINE search out 5 up-regulate genes，for example：ITPA、IMPDH2、RPS7、PDE5A and PDE4D，down-regurate genes as GNAS、CFTR、BUB3、PRKDC、RBL2、SMC1A、CALR、CCNE2 and CHEK1. Survival analysis shows that overall survival was longer when comparing high expression team of CALR and PRKDC with low expression team.Expression of CALR and PRKDC gradually reduces as Cisplatin injection times increase in SKOV3-GFP and SKOV3/DDPⅱtumor. Conclusion Expression of CALR and PRKDC may be associated  with cisplatin resistance.So reducing expression of CALR and PRKDC mean that these ovarian cancer patientsmay have resistance to cisplatin. Related Articles | Metrics

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Curcumin analogs induce autophagy in A549 cells and inhibit proliferation XU Ya-lai，ZHOU Guang-zhou，XIA Xi-zheng，CHEN Xiao-bing 2013, 5 (3):  216-221.  doi: 10.3969/j.issn.1674-5671.2013.03.06 Abstract ( 475 )   PDF (765KB) ( 548 )   Save Objective To explore the ability of curcumin analog Sunwsz08 to induce autophagy in A549 cells as well as inhibit their proliferation. Methods A549 cultures were incubated with various concentrations of Sunwsz08 for different durations， and their morphology was examined using an inverted microscope.The cultures were stained with acridine orange and propidium iodide， and their morphology was further examined by fluorescence microscopy.In order to examine the ability of Sunwsz08 to promote autophagy，GFP-LC3 positioning was used to identify autophagic vacuoles.The MTT assay was used to assess the compound′s ability to inhibit cellular proliferation. Results At concentrations of 8 and 10 mmol/L，Sunwsz08 significantly increased autophagy in A549 cells.At concentrations above 16 mmol/L，the analog caused an increase in the number of cell vacuoles，and it induced abnormal cell morphology and cell death.Sunwsz08 also inhibited A549 proliferation in a dose-and time-dependent manner. Conclusion The curcumin analogue Sunwsz08 can induce autophagy and inhibit proliferation in A549 cells. Related Articles | Metrics

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Association between telomerase activity and chemotherapy in ovarian epithelial cancer ZHANG Han-ying，LI Dan-rong，LI Li， ZHANG Li，WANG Xi-wen，CAO Yue-hua， ZENG Ying-qiong，WANG Jie 2013, 5 (3):  221-227.  doi: 10.3969/j.issn.1674-5671.2013.03.07 Abstract ( 370 )   PDF (524KB) ( 487 )   Save Objective To examine possible associations between telomerase activity and clinicopathological features of ovarian epithelial cancer patients and examine the ability of different cisplatin-based chemotherapy protocols to inhibit telomerase activity. Methods Tumor reduction surgery combined with lymph node dissection were performed in 43 patients with primary ovarian epithelial cancer.Cancer tissue from all patients was analyzed by TRAP-PCR-augmentation to detect telomerase activity，RT-PCR to measure hTERT gene expression， and immunohistochemistry to measure hTERT protein expression. Patients were divided into three treatment groups，each of which received an average of 6.5 cycles（range，6-8）of a different cisplatin-based chemotherapy：CC，cisplatin+cyclophosphamide；CP，cisplatin+paclitaxel；CCD，cisplatin+cyclophosphamide+doxorubicin.All patients were subjected to clinical and imaging exams；second-look laparotomy was also performed in patients with normal CA125 levels and no residual tumor（13 CC patients，11 CP patients，and 6 CCD patients）.Tissues around the original lesions were checked by biopsy.All patients were followed up to calculate 5-year survival rate. Results Telomerase activity did not correlate with pathology type，grade or FIGO stage in the entire group of patients（P<0.05）.All three chemotherapy protocols significantly reduced telomerase activity and hTERT protein expression （P<0.05）.The 5-year survival rate was similar for all three protocols（P>0.05）. Conclusions Cisplatin-based chemotherapy significantly suppresses telomerase activity.CP chemotherapy can decrease telomerase activity more than CC or CCD therapy， but this does not translate into a higher 5-year survival rate， perhaps because of drug resistance. Related Articles | Metrics

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Comparison of CyberKnife dosing based on lung volume in the supine or prone position to treat metastatic tumor in the spinous process of thoracic vertebra LI Yu，XU Hui-jun，ZHANG Su-jing 2013, 5 (3):  227-230.  doi: 10.3969/j.issn.1674-5671.2013.03.08 Abstract ( 344 )   PDF (262KB) ( 523 )   Save Objective To compare CyberKnife doses based on lung volume determined with the patient in the supine or prone position in order to maximize efficacy of treating metastatic tumors in the spinous process of thoracic vertebra while minimizing damage to normal tissues. Method A total of 9 patients with metastatic tumors in the spinous process of thoracic vertebra were treated using CyberKnife dosing plans based on the supine or prone position， and outcomes were compared between the two approaches. Results Compared to the treatment based on the prone lung volume，treatment based on the supine lung volume required an additional 14，862-36，337 MU，lung V5 was 5.20-7.90 Gy higher，and lung V20 was 2.61-5.73 Gy higher. In addition， the treatment based on supine lung volume delivered -2.21-2.67 Gy more to the spine volume，-3.93-7.85 Gy more to the skin volume，and 0.28-6.39 Gy more to the esophagus. Conclusion Planning Cyberknife treatment based on the lung volume determined with the patient in the prone position may allow lower total radiation doses to be used and reduce exposure of adjacent healthy tissue.  Related Articles | Metrics

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Changes in tumor volume during intensity-modulated radiotherapy for non-small cell lung cancer SU Sheng-fa，LU Bing，MA Zhu，XIAO Yue-hua，OUYANG Wei-wei，LI Qing-song，HU Yin-xiang，LI Hui-qin 2013, 5 (3):  231-235.  doi: 10.3969/j.issn.1674-5671.2013.03.09 Abstract ( 370 )   PDF (322KB) ( 511 )   Save Objective To analyze changes in target tumor volume during intensity-modulated radiotherapy（IMRT）for non-small cell lung cancer（NSCLC）. Methods A total of 25 NSCLC patients underwent IMRT.With the following dose series（Gy）:20，30，40，50.5 and 61，simulation computed tomography scans were carried out before each treatment to measure changes in gross tumor volume（GTV）and gross target volume of mediastinal nodes（GTVnd）. Results Both GTV and GTVnd decreased over the course of IMRT.The lowest dose causing significant changes from baseline was 40 Gy：GTV，t=5.019，P=0.000；GTVnd，t=5.267，P=0.000.IMRT was associated with significant decreases in GTV and GTVnd even after patients were grouped according to initial tumor volumes：GTV≥101.45 cm3，t=6.019，P=0.000；GTV＜101.45 cm3，t=6.491，P=0.000；GTVnd≥50.35cm3，t=5.449，P=0.000；GTVnd＜50.35 cm3 ,t=7.919，P=0.000.However，volume changes were greater for larger tumors than for smaller ones. Conclusions GTV and GTVnd gradually decreased over the course of IMRT，with larger tumors showing greater decreases. Significant decreases in GTV and GTVnd occurred even after treatment at 40 Gy. Related Articles | Metrics

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Correlation of postoperative cellular immune function and recurrence in primary liver cancer QIN Ying-rong，LIN Yuan，MO Xian-wei，LUO Han-zhuan，LIU Shao-ping 2013, 5 (3):  235-238.  doi: 10.3969/j.issn.1674-5671.2013.03.10 Abstract ( 442 )   PDF (284KB) ( 539 )   Save Objective To explore the possible correlation between dynamic changes in immune function and postsurgical recurrence in patients with primary liver cancer. Methods We followed up 42 patients with primary liver cancer who had surgery between 2001 to 2010，and we measured levels of T lymphocyte subpopulations every two months.The measurements were also performed in 10 healthy control individuals.Percentages of lymphocyte subpopulations were compared between the patients and healthy controls，as well as between the 16 patients with recurrence during follow-up and the 26 patients without recurrence. Results Percentages of CD3+，CD4+，and CD8+ cell populations were significantly higher in patients than in healthy controls（P<0.05）.Among patients，T lymphocyte counts were significantly lower in the recurrence group than in the non-recurrence group（P<0.05）. In the recurrence group，the CD4+ subpopulation and CD4+/CD8+ ratio increased with longer tumor-free time after surgery，while the CD8+ and CD3+ subpopulations decreased.In the non-recurrence group，CD4+ and CD3+ subpopulations increased with longer tumor-free time after surgery. Conclusions Recurrence of primary liver cancer after surgery was associated with lower cellular immune function.Dynamic monitoring of cellular immunity may be useful for assessing recurrence risk and prognosis in primary liver cancer patients after surgery. Related Articles | Metrics

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Correlation between the cellular immunity status and WHO classification of intracranial tumors DENG Teng，ZENG Xian-jie，XU Jian，MO Li-gen 2013, 5 (3):  239-242.  doi: 10.3969/j.issn.1674-5671.2013.03.11 Abstract ( 352 )   PDF (295KB) ( 601 )   Save Objective To investigate whether the cellular immunity status of intracranial tumors correlates with their WHO classification. Methods In this retrospective analysis of 79 patients operated on for intracranial tumors between August 2010 and May 2013，flow cytometry was used to assess levels of various T cell populations in the tumor tissue，and the WHO classification of the tissue was determined by postoperative pathology.Possible correlations between T cell populations and WHO classification were investigated using Spearman′s rank correlation. Results In the final analysis of 57 patients， levels of T cells positive for CD3+，CD4+/CD8+，CD8+，CD16+ CD56+ and CD19+ did not correlate with WHO classification.However， the level of CD4+ T cells negatively correlated with WHO classification （P<0.05）. Conclusions In intracranial tumors，cellular immunity status does not significantly correlate with WHO classification. Related Articles | Metrics

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Clinical efficacy and toxicity of TACE combined with sorafenib in advanced hepatocellular carcinoma   YE Xin-ping，PENG Tao，SHANG Li-ming，PENG Ning，LI Jia-mei，QIN Xiao，SU Zhi-xiong 2013, 5 (3):  242-245.  doi: 10.3969/j.issn.1674-5671.2013.03.12 Abstract ( 435 )   PDF (321KB) ( 816 )   Save Objective To explore the clinical efficacy and adverse reactions associated with transcatheter arterial chemoembolization （TACE）combined with sorafenib in advanced hepatocellular carcinoma（HCC）. Methods A total of 70 patients with advanced and late HCC were divided into two treatment groups: one received TACE combined with sorafenib， while the other was treated by TACE alone.Tumor response was assessed every 4-8 weeks using Response Evaluation Criteria for Solid Tumors（RECIST）.Clinical efficacy and adverse effects associated with sorafenib were evaluated. Median overall survival（OS） and median time to progression （TTP） were compared between the two groups. Results Median OS was significantly shorter in the combination therapy group（8.2 months）than in the TACE-only group（14.8 months；P<0.05）.The combination therapy group also showed significantly shorter median TTP（10.3 months vs 5.8 months，P<0.05）.The rate of adverse reactions in the combination therapy group was 77.1%. Conclusions TACE combined with sorafenib is effective for treating patients with advanced and late HCC，and it is associated with tolerable side effects. Related Articles | Metrics

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Comparing the therapeutic efficacy of TACE combined with psychro-circulation percutaneous microwave coagulation therapy or radioactive 125I particle implantation to treat large primary liver cancer ZHANG Shi-jie，MA Yi-long，KANG Ping，MENG Zhi-bin，LI Zhi-kun，OU Sheng-qiu，QI Feng，ZHAO Chang 2013, 5 (3):  246-249.  doi: 10.3969/j.issn.1674-5671.2013.03.13 Abstract ( 415 )   PDF (300KB) ( 556 )   Save Objective To compare the therapeutic efficacy of transcatheter arterial chemoembolization （TACE） combined with either psychro-circulation percutaneous microwave coagulation therapy or radioactive 125I particle implantation for treating large primary liver cancer （LPLC）. Methods A total of 46 patients with LPLC underwent TACE and psychro-circulation percutaneous microwave coagulation therapy using the ECO-100 system， while 20 patients underwent TACE and radioactive 125I particle implantation.At 2 and 3 months after treatment， patients were analyzed by dynamic enhanced computed tomography scanning，and adverse reactions and complications were recorded. Results At 3 months after treatment，TACE combined with psychro-circulation percutaneous microwave coagulation therapy gave a local control rate of 82.61%，compared to 55.00% for TACE combined with radioactive 125I particle implantation （P<0.05）. The two methods gave similar clinical control rates of 93.47% and 85.00%，respectively （P>0.05）.In addition，the two groups did not differ significantly in adverse reactions，and neither group showed serious complications. Conclusion TACE combined with either psychro-circulation percutaneous microwave coagulation therapy or radioactive 125I particle implantation is effective for treating LPLC，and both methods cause similar adverse reactions.Of the two combination therapies，TACE combined with psychro-circulation percutaneous microwave coagulation therapy is more effective for treating LPLC. Related Articles | Metrics

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Diagnostic value of high-frequency color Doppler ultrasound for detecting parotid masses LIU Lian-feng,LI Hang 2013, 5 (3):  250-253.  doi: 10.3969/j.issn.1674-5671.2013.03.14 Abstract ( 408 )   PDF (333KB) ( 491 )   Save Objective To assess the diagnostic value of high-frequency color Doppler ultrasound（HCDU） for detecting parotid masses. Methods A total of 58 patients with parotid masses were analyzed by pathology and by HCDU，and the diagnostic performance of the two methods was compared. Results HCDU detected 100% of masses. Diagnostic coincidence rates were 87.2% for benign masses， 68.4% for malignant masses and 100% for cysts. Two-dimensional ultrasound detected significant differences between benign and malignant parotid masses in shape，boundary，edge and internal echo（P<0.05）.Color Doppler flow imaging （CDFI） detected blood flow signals in 82.1% of benign and 94.7% of malignant masses.HDCU showed a sensitivity of 73.7% and a specificity of 71.8% based on a peak systolic velocity≥23.8 cm/s as indicative of a malignant mass；the corresponding values were 73.3% and 85.0% based on a resistance index≥0.68 as indicative of a malignant mass（including mixed tumors）. Conclusion HCDU showed high rates of detection and diagnostic coincidence for parotid masses， and it proved helpful for assessing the characteristics of parotid tumors. Related Articles | Metrics

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Comparison of breast magnetic resonance sequences for improving image quality ZHENG Fei,WANG Li-na 2013, 5 (3):  253-255.  doi: 10.3969/j.issn.1674-5671.2013.03.15 Abstract ( 381 )   PDF (295KB) ( 684 )   Save Objective To compare breast magnetic resonance sequences for their ability to generate high-quality images. Methods A total of 75 subjects were analyzed by breast magnetic resonance imaging using T2WI，DWI，dynamic contrast-enhanced and delayed T1WI sequences.The image quality produced by each approach was assessed. Results High-quality images were obtained for 93.33% of patients using T2WI，18.66% using DWI，72.00% using dynamic contrast-enhanced T1WI and 97.33% using delayed T1WI. Conclusions In order to improve the quality of breast magnetic resonance images，we recommend reducing motion artifacts，optimizing the imaging sequence to reduce examination time，properly applying fat suppression techniques，ensuring that the b value for the DWI sequence is chosen correctly， and exploiting the full potential of the integrated parallel acquisition technique （iPAT）. Related Articles | Metrics

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Effects of malignant tumor complication on treatment of acute lower limb deep venous thrombosisn ZHU Qi-cong,WANG Ya-hui,Yu Shu-yong 2013, 5 (3):  256-258.  doi: 10.3969/j.issn.1674-5671.2013.03.16 Abstract ( 423 )   PDF (274KB) ( 455 )   Save Objective To investigate how malignant tumor complication affects the therapeutic efficacy of thrombolysis and anticoagulation to treat acute lower limb deep venous thrombosis（DVT）. Methods A total of 34 patients with acute lower limb DVT complicated by malignant tumor and 34 patients with acute lower limb DVT following an operation or injury were recruited.Both groups were treated with conventional therapy of thrombolysis and anticoagulation，and the effects of the malignant tumor complication on therapeutic efficacy were assessed. Results The recanalization rate and effective therapeutic rate were lower in the group with a malignant tumor complication than in the group without it（P<0.05）. Conclusions Conventional therapy is not effective for treating acute lower limb DVT complicated with malignant tumor. Related Articles | Metrics

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Clinical effects of preoperative fasting time on postoperative blood glucose level in hepatic cancer patients under continuous operation YANG Yan-fang,MO Xin-shao,CHEN Si-xia,ZHONG Li,YANG Hai-qing 2013, 5 (3):  259-262.  doi: 10.3969/j.issn.1674-5671.2013.03.17 Abstract ( 388 )   PDF (303KB) ( 462 )   Save Objective To explore the effects of preoperative fasting time on postoperative blood glucose level in primary liver cancer （PLC） patients under continuous operation. Methods A total of 96 PLC patients were divided into two groups；those receiving continuous operation（continuous group，n=40） and those receiving the first operation（the first group，n=56）.Fasting blood glucose levels were compared before the operation and on days 1，3，5 and 7 afterwards. Results Preoperative fasting time was longer in the continu-ous group than in the first group（P<0.01）.Fasting blood glucose levels on days 3，5，and 7 was higher in the continuous group than in the first group（P＜0.01）. Conclusions Extended preoperative fasting time may contribute to postoperative hyperglycemia in PLC patients.Greater attention should be paid to providing individualized preoperative dietary guidance to patients under continuous operation to reduce the occurrence of postoperative stress hyperglycemia. Related Articles | Metrics

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Efficacy of nursing intervention to improve quality of life in patients with ovarian cancer after chemotherapy YU Li,HUANG Yi-hua,SHI Gui-ning 2013, 5 (3):  262-265.  doi: 10.3969/j.issn.1674-5671.2013.03.18 Abstract ( 476 )   PDF (306KB) ( 1341 )   Save Objective To explore the influence of holistic nursing intervention on the quality of life of patients with ovarian cancer after chemotherapy. Methods A total of 84 patients with ovarian cancer treated by chemotherapy were randomly divided into a con-trol group（n=43），who received routine nursing care； and an intervention group （n=41），who received holistic nursing intervention. Patients were assessed before chemotherapy and 3 months afterwards using the Self-rating Depression Scale， Self-rating Anxiety Scale （SAS） and the Quality of Life EORTC QLQ-C30 scale. Results After chemotherapy，the intervention group showed significantly higher scores than the control group for overall quality of life and for physical， emotional， and social function（P<0.05）. At the same time， the intervention group showed lower scores on individual symptom dimensions of fatigue，nausea and vomiting，insomnia，and decreased appetite（P<0.05）. Conclusion Holistic nursing intervention can improve anxiety，depression，and quality of life in patients with ovarian cancer following chemotherapy. Related Articles | Metrics

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Nursing of intrapleural injection of endostar combined with  chemotherapeutics in malignant pleural effusion ZENG Shan,LI Gao-hua,CHEN Li-jun,Lv Xiao-hong,Huang Ying-fan,Jiang Jin-fang 2013, 5 (3):  266-268.  doi: 10.3969/j.issn.1674-5671.2013.03.19 Abstract ( 357 )   PDF (309KB) ( 425 )   Save Related Articles | Metrics

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Research and practice in clinical education of gynecologic oncology SONG Hong-lin,YAO De-sheng,MO Ling-zhao,Long Ying 2013, 5 (3):  268-270.  doi: 10.3969/j.issn.1674-5671.2013.03.20 Abstract ( 276 )   PDF (295KB) ( 636 )   Save Related Articles | Metrics

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The experience of clinical teaching in surgical oncology for overseas students YANG Hua-wei,WEI Wei 2013, 5 (3):  270-272.  doi: 10.3969/j.issn.1674-5671.2013.03.21 Abstract ( 302 )   PDF (308KB) ( 695 )   Save Related Articles | Metrics

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Cetuximab combination with FOLFOX4 regimen in K-ras gene mutated colon carcinoma with liver metastasis：a case report SU Hui,GAO Ya-jie,ZHANG Chun-xia 2013, 5 (3):  272-273.  doi: 10.3969/j.issn.1674-5671.2013.03.22 Abstract ( 323 )   PDF (350KB) ( 522 )   Save Related Articles | Metrics

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Case report:a huge recurrent neuromatosa ZHOU Yan-bo,LI Shi-de 2013, 5 (3):  274-275.  doi: 10.3969/j.issn.1674-5671.2013.03.23 Abstract ( 353 )   PDF (358KB) ( 637 )   Save Related Articles | Metrics

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MACC1 gene and neoplasms ZHOU Na,WU Yi-lin 2013, 5 (3):  276-279.  doi: 10.3969/j.issn.1674-5671.2013.03.24 Abstract ( 390 )   PDF (296KB) ( 918 )   Save Related Articles | Metrics

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Advances in the clinical research of adoptive cellular immunotherapy for renal cancer CHEN Jie,LUO Xiao-ling,ZHANG Li-tu 2013, 5 (3):  280-283.  doi: 10.3969/j.issn.1674-5671.2013.03.25 Abstract ( 336 )   PDF (293KB) ( 476 )   Save Related Articles | Metrics

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Research progress of early enteral nutrition in esophagus cancer and its nursing care XIE Shou-mei,XIE Xiao-yong 2013, 5 (3):  284-286.  doi: 10.3969/j.issn.1674-5671.2013.03.26 Abstract ( 371 )   PDF (309KB) ( 606 )   Save Related Articles | Metrics

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Research progress of nasal lavage  on irradiation-induced rhinosinusitis in patients with nasopharyngeal carcinoma TANG Zhong-min 2013, 5 (3):  287-289.  doi: 10.3969/j.issn.1674-5671.2013.03.27 Abstract ( 406 )   PDF (306KB) ( 704 )   Save Related Articles | Metrics

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Diagnostic value of fine-needle aspiration biopsy for breast mass: a systematic review and meta-analysis YU Ying-Hua 2013, 5 (3):  290-290.  doi: 10.3969/j.issn.1674-5671.2013.03.28 Abstract ( 319 )   PDF (193KB) ( 372 )   Save Related Articles | Metrics