肝肿瘤, 乙型肝炎病毒, 基因型, 筛查

Objective To analyze data on hepatitis B virus(HBV) infection and viral genotypes collected as part of liver cancer prevention screening in Guigang City,Guangxi Province. Methods Data were collected from residents of Guigang City who agreed to participate in liver cancer screening,and 1,989 residents at high risk of liver cancer were randomly selected for quantitative detection of HBV DNA. HBV carriers with an HBV load of≥1×103 copies were subjected to analysis by PCR-RFLP to determine HBV genotypes. Result The average rate of HBsAg positivity in the study population was 11.99%,and the rate was significantly higher in males than in females(P<0.01). The rate differed significantly among different age groups(P<0.01),declining gradually with increasing age. A total of 755 HBV carriers at high risk of liver cancer were identified to have at least 1×103 HBV copies. Of these 755,6(0.79%) were infected with genotype A,337(44.64%) with genotype B,293(38.81%) with genotype C,and 18 (2.39%)with genotype D. The genotype in 101 carriers(13.37%)was untypable. These two genotypes did not differ significantly between men and women or among the different age groups. Conclusion The HBV infection rate is high in the three districts of Guigang City, with HBV genotypes B and C predominating. The rate of early detection of liver cancer is relatively low. Technology and program management should be improved to enhance the efficacy of cancer screening, early detection and treatment.

 

 

 

Liver neoplasms, Hepatitis B virus, Genotype, Screening